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A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1



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[Encyclopedia of Differential Diagnosis in Dermatology] Paul Schneiderman, Marc E. Grossman - A Clinician\'s Guide to Dermatologic Differential Diagnosis, Volume 1 The Text (Encyclopedia of Differential Diagnosis in D

244
A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Schneiderman page 200-300.qxd 5/16/2006 6:49 PM Page 244


140:689–695, 1999; JID 103:277–281, 1994; JAAD
14:1000–1005, 1986
Increased sympathetic response through T2–3 ganglia
Keratolysis exfoliativa 
Ghatan p.248, 2002, Second Edition
Keratosis palmaris et plantaris
Mal de Meleda – autosomal dominant, autosomal recessive
transgrediens with acral erythema in glove-like distribution;
perioral erythema and hyperkeratosis; hyperhidrosis; pseudo-
ainhum; lingua plicata, syndactyly, hairy palms and soles, high
arched palate, lefthandedness 
Dermatology 203:7–13, 2001;
AD 136:1247–1252, 2000; J Dermatol 27:664–668, 2000;
Dermatologica 171:30–37, 1985
Metastases – cutaneous metastases from a chondroblastoma
initially presenting as unilateral palmar hyperhidrosis 
JAAD
40:325–327, 1999
Nail–patella syndrome 
Rook p.1992, 1998, Sixth Edition
Pachyonychia congenita 
Ped Derm 7:33–38, 1990; JAAD
19:705–711, 1988
Pachydermoperiostosis 
Ghatan p.248, 2002, Second Edition
Papillon–Lefevre syndrome – autosomal recessive; diffuse
transgradiens palmoplantar keratoderma with hyperhidrosis;
periodontal disease with shedding of primary and permanent
dentition; recurrent cutaneous and systemic pyodermas;
psoriasiform plaques of elbows and knees 
JAAD 49:S240–243,
2003; J Periodontol 66:413–420, 1995; Ped Derm 11:354–357,
1994
Pitted keratolysis 
BJD 137:282–285, 1997
Pretibial myxedema 
JAAD 46:723–726, 2002
Primary hyperhidrosis
Raynaud’s phenomenon or disease 
Rook p.1992, 1998,
Sixth Edition
Reflex sympathetic dystrophy 
Br Med J 310:1645–1648, 1995
Rheumatoid arthritis
Richner–Hanhart syndrome (tyrosinemia type II) – autosomal
recessive; tyrosine aminotransferase deficiency; chromosome
16q22–q24; painful palmoplantar keratoderma with
circumscribed keratoses, bullae may occur; dendritic corneal
ulcers, mental retardation; palmoplantar hyperhidrosis; signs
include tearing, redness, pain and photophobia progressing to
superficial and deep dendritic ulcers; mental retardation;
aggregated tonofibril bundles on electron microscopy; crystal
structures 
J Pediatr 126:266–269, 1995; AD 130:507–511,
1994; AD 126:1342–1346, 1990
Symmetrical lividity of the soles 
Cutis 64:175–176, 1999; BJD
37:123–125, 1925
Unna–Thost palmoplantar keratoderma – diffuse non-
epidermolytic palmoplantar keratoderma – autosomal dominant;
mutations in keratin 16 
Hum Mol Genet 4:1875–1881, 1995;
mutation in keratin 1 
JID 103:764–769, 1994

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