Schneiderman Prelims Vol-I. qxd

INFILTRATIVE DISEASES
Pretibial myxedema – occurs in 1–10% of patients with
Grave’s disease; often associated with exophthalmos
Lancet
341:403–404, 1993; JAAD 14:1–18,1986; AD 117:250–251,
1981; elephantiasic pretibial myxedema JAAD 46:723–726,
2002
Sarcoidosis – 
JAAD 30:498, 1993; J R Soc Med 78:260–261,
1985; unilateral leg edema JAAD 44:725–743, 2001
INFLAMMATORY DISEASES
Bursitis – iliopectineal – iliofemoral vein compression
J Vasc Surg 13:725–727, 1991; iliopsoas J Rheumatol
13:197–200, 1986
Erythema induratum (Whitfield) – nodules with edematous
ankles 
Rook p.2207, 1998, Sixth Edition
Muscle infarction 
Am J Kidney Dis 35:1212–1216, 2000
Pancreatic pseudocyst – compression of inferior vena cava
Mayo Clin Proc 67:1085–1088, 1992
Panniculitis 
Rook p.2284, 1998, Sixth Edition
RS3PE – remitting seronegative symmetrical synovitis with
pitting edema
JAMA 254:2763, 1985
Sarcoidosis – bilateral leg edema as presenting sign 
Am J Med
Sci 318:413–414, 1999; unilateral leg edema JAAD
30:498–500, 1994; AD 109:543–544, 1974
METABOLIC DISEASES
Acromegaly
Beriberi (vitamin B
1
, thiamine deficiency) – anorexia, weakness,
constipation, polyneuritis, cardiac failure with edema, muscle
wasting 
Am J Med 113:580–586, 2002; JAAD 21:15–18, 1989
Carcinoid syndrome – dependent edema due to low serum
proteins 
BJD 152:71–75, 2005
Cirrhosis, liver failure 
Am J Med 113:580–586, 2002
Congestive heart failure – ankle edema 
Ghatan p.49, 2002,
Second Edition
Cryofibrinogenemia – edema and bullae of feet 
Am J Med
116:332–337, 2004
Fluid retention – ankle edema 
Ghatan p.49, 2002, Second Edition
Hypoalbuminemia of any cause
Kwashiorkor 
JAAD 52:S69–72, 2005; Cutis 67:321–327, 2001
Liver cyst – inferior vena cava compression 
Acta Med Scand
205:541–542, 1979
Malabsorption 
Am J Med 113:580–586, 2002
Myxedema 
Am J Med 113:580–586, 2002
Obesity, massive 
Rook p.2247, 1998, Sixth Edition; NEJM
327:1927, 1993
Pre-eclampsia 
Am J Med 113:580–586, 2002
Pregnancy 
Am J Med 113:580–586, 2002; Rook p.2247,3270,
1998, Sixth Edition
Premenstrual edema 
Am J Med 113:580–586, 2002; Rook
p.2247, 1998, Sixth Edition
Prolidase deficiency – autosomal recessive; skin spongy and
fragile with annular pitting and scarring; leg ulcers;
photosensitivity, telangiectasia, purpura, premature graying,
lymphedema 
Ped Derm 13:58–60, 1996; JAAD 29:819–821,
1993; AD 127:124–125, 1991; AD 123:493–497, 1987
Rhabdomyolysis – acute swollen legs 
BMJ 309:1361–1362, 1994
Renal failure 
Am J Med 113:580–586, 2002; nephrotic
syndrome 
Rook p.2247, 1998, Sixth Edition
Scurvy – woody edema of legs 
BJD 80:625–628, 1968
Spherocytosis – pseudoerysipelas due to recurrent hemolysis
JAAD 51:1019–1023, 2004