Schneiderman Prelims Vol-I. qxd

BLUE SPOTS
AUTOIMMUNE DISEASES, AND DISEASES
OF IMMUNE DYSFUNCTION
Autoerythrocyte sensitization
Graft vs. host disease
Lupus erythematosus, neonatal
CONGENITAL ANOMALIES
Branchial cleft cyst (cystic papule) 
AD 128:1395–1400, 1992
Cephalocoele – includes anterior encephalocele 
JAAD
51:577–579, 2004; meningomyelocele; blue nodule with
overlying hypertrichosis 
JAAD 46:934–941, 2002; AD
137:45–50, 2001
Congenital hemangioma of the eccrine sweat gland 
Ped Derm
10:341–343, 1993
Dermoid cyst – blue nodule 
JAAD 46:934–941, 2002
Heterotopic brain tissue (heterotopic meningeal nodules) –
blue–red cystic mass with overlying alopecia
Dermatol Therapy
18:104–116, 2005; JAAD 46:934–941, 2002; bald cyst of scalp
with surrounding hypertrichosis 
AD 131:731, 1995; JAAD
28:1015, 1993; BJD 129:183–185, 1993; AD 125:1253–1256,
1989
Mucocele of lacrimal sac – blue cystic swelling below medial
canthus 
Textbook of Neonatal Dermatology, p.485, 2001
Nasal encephalocele 
Dermatol Therapy 18:104–116, 2005
Nasal glioma 
Dermatol Therapy 18:104–116, 2005
DEGENERATIVE DISEASES
Digital mucous pseudocyst – 
Arthr Rheum 20:997–1002, 1977
DRUG-INDUCED
Amiodarone – blue, blue–gray, slate gray 
Clin Cardiol
19:592–594, 1996; JAAD 11:898–900, 1984; BJD
110:451–456, 1984
Antimalarials – blue–gray pigmentation of face, neck, forearms,
lower legs 
AD 88:419–426, 1963; yellow and blue pigmentation
of pretibial areas and hard palate 
JAAD 39:524–525, 1998;
blue nails 
Ghatan p.78, 2002, Second Edition
AZT – blue nails
Bismuth – blue linear hyperpigmentation of gingival margin, soft
palate, lead 
JAAD 37:489–490, 1997; AD 129:474–476, 1993
Bleomycin – blue nails 
Ghatan p.78, 2002, Second Edition
Combination chemotherapy – cyclophosphamide, vincristine,
doxorubicin, dacarbazine; blue lunulae 
JAAD 32:296, 1995
Chloroquine – blue–gray pigmentation of shins 
Ghatan p.231,
2002, Second Edition; blue–black nail beds AD 88:419–426,
1963
Chlorpromazine 
JAAD 53:S105–107, 2005
Clofazimine in DLE 
JAAD 17:867–871, 1987
Clomipramine 
Am J Psychiatry 146:552–553, 1989
Desipramine photopigmentation 
AD 129:474–476, 1993
Diltiazem – reticulated, blue–gray, photodistributed
hyperpigmentation 
JAAD 46:468–469, 2002;
AD 137:179–182, 2001
Fixed drug eruptions
Gold (chrysiasis) 
BJD 133:671–678, 1995
Hydroxychloroquine – blue–black pigmentation 
Ghatan p.231,
2002, Second Edition
Imipramine 
JAAD 25:357–361, 1991
Iron
Lead 
JAAD 37:489–490, 1987
Mepacrine – blue nails 
BJD 130:794–795, 1994
Mercury
Methylene blue by intravenous injection – blue macules or blue
skin; mimics cyanosis 
Cutis 63:103–106, 1999; NEJM
320:1756–1757, 1989
Minocycline – blue–black scleral, dental, and cutaneous
pigmentation 
Rook p.1960, 1998, Sixth Edition; Am J
Ophthalmol 125:396–397, 1998; including pseudo-Mongolian
spot 
AD 128:565–566, 1992; post-acne osteoma cutis treated
with minocycline 
JAAD 24:851–853, 1991; blue nails Ghatan
p.78, 2002, Second Edition; blue epithelial buds
Perfloxin – blue-black pretibial hyperpigmentation 
JAAD
37:365–381, 1997
Phenolphthalein (X-Lax) – blue lunulae 
Ghatan p.80, 2002,
Second Edition
Phenothiazine
Quinacrine
Quinidine 
AD 122:1062–1064, 1986
Quinine – exogenous ochronosis from quinine injections 
JAAD
15:357–361, 1986