Сборник содержит материалы научной мультиконференции «Биотех- нология медицине будущего»

Phage therapy in the clinics of cardiothoracic and transplantation surgery
Rubalskii E.
1,2,3
, Ruemke S.
1,2
, Salmoukas C.
1,2
, Aleshkin A.
3
, Kuehn C.
1,2
, Haverich A.
1,2
1
Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical 
School, Hannover, Germany 
2
Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, 
Hannover, Germany 
3
Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia
Bacterial infections associated with implanted medical devices or with a medicamental 
immunosuppression are one of the most severe complications of modern surgery. Conven-
tional antibacterial therapy often is not enough for treatment of such cases not only because 
of emerging of multiple antibiotic resistance but also because of development of antibiotic 
tolerance due to local or systemic failure of immune system factors. Individually selected 
bacteriophages and their cocktails are of viable alternatives or additions to antibiotic therapy.
We successfully prepared and applied personalized phage preparations as an 
ultima ratio
therapy. The phage therapy was obtained by patients with infections of lungs and soft tissues 
after a medicamental immunosuppression as well as with infected implanted aortic arch grafts, 
infusion pumps and left ventricular assist devices. The phage therapy showed its prospects and 
ability to eliminate such infections when using an adequate method and route of adminis-
tration of bacteriophage preparations.

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Всероссийская мультиконференция с международным участием «Биотехнология – медицине будущего»
29 июня - 2 июля 2019 г., г. Новосибирск, Россия
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