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CIE AS Biology (9700) 2019-2021 CIE AS Biology (9700) 2019-2021 2.1.1 Biological Molecule Tests SaveMyExams

Globular proteins are compact, roughly spherical (circular) in shape and soluble in water

Globular proteins form a spherical shape when folding into their tertiary structure because:

their non-polar hydrophobic R groups are orientated towards the centre of the

protein away from the aqueous surroundings and

their polar hydrophilic R groups orientate themselves on the outside of the

protein


This orientation enables globular proteins to be (generally) soluble in water as the water

molecules can surround the polar hydrophilic R groups

The solubility of globular proteins in water means they play important physiological roles

as they can be easily transported around organisms and be involved in metabolic



reactions

The folding of the protein due to the interactions between the R groups results in globular

proteins having specific shapes. This also enables globular proteins to play physiological

roles, for example, enzymes can catalyse specific reactions and immunoglobulins can

respond to specific antigens

Some globular proteins are conjugated proteins that contain a prosthetic group eg.

haemoglobin which contains the prosthetic group called haem

Fibrous



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