Results: 1 to 20 of 162 Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate

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Results: 1 to 20 of 162

1. Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L.) Seed Oil on Breast Cancer Cell Lines.

Costantini S, Rusolo F, De Vito V, Moccia S, Picariello G, Capone F, Guerriero E, Castello G, Volpe MG. Molecules. 2014 Jun 24;19(6):8644-60..

2. Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts.

Zahin M, Ahmad I, Gupta RC, Aqil F. Biomed Res Int. 2014;2014:467465.

3. Pomegranate Juice and Prostate Cancer: Importance of the Characterisation of the Active Principle.

Chrubasik-Hausmann S, Vlachojannis C, Zimmermann B. Phytother Res. 2014 Jun 3. doi: 10.1002/ptr.5181. [Epub ahead of print]

4.  The structure, occurrence and biological activity of ellagitannins: a general review.

Lipińska L, Klewicka E, Sójka M. Acta Sci Pol Technol Aliment. 2014 Jul 1;13(3):289-99.

5. Beyond Androgen Deprivation: Ancillary Integrative Strategies for Targeting the Androgen Receptor Addiction of Prostate Cancer.

McCarty MF, Hejazi J, Rastmanesh R. Integr Cancer Ther. 2014 May 26. pii: 1534735414534728. [Epub ahead of print] Review.

6. Effect of botanicals on inflammation and skin aging: analyzing the evidence.

Suggs A, Oyetakin-White P, Baron ED. Inflamm Allergy Drug Targets. 2014;13(3):168-76.

7. Effects of Dietary Components on Cancer of the Digestive System.

Zanini S, Marzotto M, Giovinazzo F, Bassi C, Bellavite P. Crit Rev Food Sci Nutr. 2014 May 19. [Epub ahead of print]

8. Pomegranate fruit as a rich source of biologically active compounds.

Sreekumar S, Sithul H, Muraleedharan P, Azeez JM, Sreeharshan S. Biomed Res Int. 2014;2014:686921.

9. A polysaccharide from pomegranate peels induces the apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway.

Li J, Zhang F, Wang S. Tumour Biol. 2014 May 2. [Epub ahead of print]

13. Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo.

Ming DS, Pham S, Deb S, Chin MY, Kharmate G, Adomat H, Beheshti EH, Locke J, Guns ET. J Steroid Biochem Mol Biol. 2014 Feb 22;143C:19-28

14. Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts.

Waly MI, Al-Rawahi AS, Al Riyami M, Al-Kindi MA, Al-Issaei HK, Farooq SA, Al-Alawi A, Rahman MS. BMC Complement Altern Med. 2014 Feb 18;14:60.

15. Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients.

Nuñez-Sánchez MA, García-Villalba R, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, Martínez-Díaz F, Yáñez-Gascón MJ, González-Sarrías A, Tomás-Barberán FA, Espín JC. Mol Nutr Food Res. 2014 Jun;58(6):1199-211.

16. Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways.

Khuda-Bukhsh AR, Das S, Saha SK. Nutr Cancer. 2014;66(2):194-205.

17. Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy.

Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K, Ritenour C, Kucuk O, Wu D. Prostate. 2013 Dec 23. doi: 10.1002/pros.22769. [Epub ahead of print]

18. Suppression of urinary bladder urothelial carcinoma cell by the ethanol extract of pomegranate fruit through cell cycle arrest and apoptosis.

Lee ST, Lu MH, Chien LH, Wu TF, Huang LC, Liao GI. BMC Complement Altern Med. 2013 Dec 21;13:364.

19. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis.

Marín M, María Giner R, Ríos JL, Recio MC. J Ethnopharmacol. 2013 Dec 12;150(3):925-34.

20. Daily Pomegranate Intake Has No Impact on PSA Levels in Patients with Advanced Prostate Cancer - Results of a Phase IIb Randomized Controlled Trial.

Stenner-Liewen F, Liewen H, Cathomas R, Renner C, Petrausch U, Sulser T, Spanaus K, Seifert HH, Strebel RT, Knuth A, Samaras P, Müntener M. J Cancer 2013;4(7):597-605.

21. A galactomannan polysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity.

Joseph MM, Aravind SR, George SK, Varghese S, Sreelekha TT. Carbohydr Polym. 2013 Nov 6;98(2):1466-75.

22. Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR.

Banerjee N, Kim H, Talcott S, Mertens-Talcott S. Carcinogenesis. 2013 Dec;34(12):2814-22.

23. A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy.

Freedland SJ, Carducci M, Kroeger N, Partin A, Rao JY, Jin Y, Kerkoutian S, Wu H, Li Y, Creel P, Mundy K, Gurganus R, Fedor H, King SA, Zhang Y, Heber D, Pantuck AJ. Cancer Prev Res (Phila). 2013 Oct;6(10):1120-7.

24. Complementary and alternative medicine (CAM) in prostate and bladder cancer.

Philippou Y, Hadjipavlou M, Khan S, Rane A. BJU Int. 2013 Dec;112(8):1073-9.

25. Ellagic acid inhibits migration and invasion by prostate cancer cell lines.

Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P. Asian Pac J Cancer Prev. 2013;14(5):2859-63.

26. Chemical composition and antioxidant, anti-inflammatory, and antiproliferation activities of pomegranate (Punica granatum) flowers.

Bekir J, Mars M, Vicendo P, Fterrich A, Bouajila J. J Med Food. 2013 Jun;16(6):544-50. doi: 10.1089/jmf.2012.0275.

27. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents.

Viladomiu M, Hontecillas R, Lu P, Bassaganya-Riera J. Evid Based Complement Alternat Med. 2013;2013:789764.

28. Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.

Sadik NA, Shaker OG. Dig Dis Sci. 2013 Sep;58(9):2507-17.

29. Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis.

Vicinanza R, Zhang Y, Henning SM, Heber D. Evid Based Complement Alternat Med. 2013;2013:247504.
30. Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway.
Bhatia D, Thoppil RJ, Mandal A, Samtani KA, Darvesh AS, Bishayee A.

Evid Based Complement Alternat Med. 2013;2013:371813.

31. Pomegranate Extracts in the Management of Men's Urologic Health: Scientific Rationale and Preclinical and Clinical Data.
Kroeger N, Belldegrun AS, Pantuck AJ. Evid Based Complement Alternat Med. 2013;2013:701434. doi: 10.1155/2013/701434. Epub 2013 Mar 26. Erratum in: Evid Based Complement Alternat Med. 2013;2013:870454. N, Kroeger [corrected to Kroeger, Nils]; A S, Belldegrun [corrected to Belldegrun, A S]; A J, Pantuck [corrected to Pantuck, A J].
32. Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk.
Aqil F, Munagala R, Vadhanam MV, Kausar H, Jeyabalan J, Schultz DJ, Gupta RC.

Food Res Int. 2012 Nov 1;49(1):345-353. Epub 2012 Aug 7.

33. Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study.
Gasmi J, Thomas Sanderson J. Phytomedicine. 2013 Jun 15;20(8-9):734-42.

34. Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines.

Dahlawi H, Jordan-Mahy N, Clench M, McDougall GJ, Maitre CL. Food Sci Nutr. 2013 Mar;1(2):196-208.
35. Spontaneous ultra fast synthesis of gold nanoparticles using Punica granatum for cancer targeted drug delivery.
Ganeshkumar M, Sathishkumar M, Ponrasu T, Dinesh MG, Suguna L. Colloids Surf B Biointerfaces. 2013 Jun 1;106:208-16.
36. Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks.
Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.

Mol Carcinog. 2014 Jun;53(6):458-70.

37. Studies on the Cytotoxic Activities of Punica granatum L. var. spinosa (Apple Punice) Extract on Prostate Cell Line by Induction of Apoptosis.

Sineh Sepehr K, Baradaran B, Mazandarani M, Khori V, Shahneh FZ. ISRN Pharm. 2012;2012:547942.

38. Pomegranate (Punica granatum) peel extract efficacy as a dietary antioxidant against azoxymethane-induced colon cancer in rat.

Waly MI, Ali A, Guizani N, Al-Rawahi AS, Farooq SA, Rahman MS. Asian Pac J Cancer Prev. 2012;13(8):4051-5.

39. Pomegranate extracts and cancer prevention: molecular and cellular activities.

Syed DN, Chamcheu JC, Adhami VM, Mukhtar H. Anticancer Agents Med Chem. 2013 Oct;13(8):1149-61. Review.

40. Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis.

Wang L, Ho J, Glackin C, Martins-Green M. Transl Oncol. 2012 Oct;5(5):344-55.

41. Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer.

Rocha A, Wang L, Penichet M, Martins-Green M. Breast Cancer Res Treat. 2012 Dec;136(3):647-58.

42. Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study.

de Vries E, Trakatelli M, Kalabalikis D, Ferrandiz L, Ruiz-de-Casas A, Moreno-Ramirez D, Sotiriadis D, Ioannides D, Aquilina S, Apap C, Micallef R, Scerri L, Ulrich M, Pitkänen S, Saksela O, Altsitsiadis E, Hinrichs B, Magnoni C, Fiorentini C, Majewski S, Ranki A, Stockfleth E, Proby C; EPIDERM Group. Br J Dermatol. 2012 Aug;167 Suppl 2:1-13.

43. In vitro and in vivo evaluation of antioxidant and antigenotoxic potential of Punica granatum leaf extract.

Dassprakash MV, Arun R, Abraham SK, Premkumar K. Pharm Biol 2012;50(12):1523-30.

44. Proteomic exploration of the impacts of pomegranate fruit juice on the global gene expression of prostate cancer cell.

Lee ST, Wu YL, Chien LH, Chen ST, Tzeng YK, Wu TF. Proteomics. 2012 Nov;12(21):3251-62.

45. Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation.

Banerjee N, Talcott S, Safe S, Mertens-Talcott SU. Breast Cancer Res Treat. 2012 Nov;136(1):21-34. doi: 10.1007/s10549-012-2224-0. Epub 2012 Sep 2.

46. Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.

Bishayee A, Thoppil RJ, Darvesh AS, Ohanyan V, Meszaros JG, Bhatia D. J Nutr Biochem. 2013 Jan;24(1):178-87. doi: 10.1016/j.jnutbio.2012.04.009. Epub 2012 Jul 25.

47. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects.

Ismail T, Sestili P, Akhtar S. J Ethnopharmacol. 2012 Sep 28;143(2):397-405.

48. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer.

Paller CJ, Ye X, Wozniak PJ, Gillespie BK, Sieber PR, Greengold RH, Stockton BR, Hertzman BL, Efros MD, Roper RP, Liker HR, Carducci MA. Prostate Cancer Prostatic Dis. 2013 Mar;16(1):50-5. doi: 10.1038/pcan.2012.20. Epub 2012 Jun 12.

49. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota.

Neyrinck AM, Van Hée VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. Br J Nutr. 2013 Mar 14;109(5):802-9. doi: 10.1017/S0007114512002206. Epub 2012 Jun 7.

50. Complementary and alternative medicines in prostate cancer: from bench to bedside?

Klempner SJ, Bubley G. Oncologist. 2012;17(6):830-7. doi: 10.1634/theoncologist.2012-0094. Epub 2012 May 22. Review.

51. Pomegranate Ellagitannins.

Heber D. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press; 2011. Chapter 10.

52. A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches.

Rahimi HR, Arastoo M, Ostad SN. Iran J Pharm Res. 2012 Spring;11(2):385-400.

53. Lycopene: redress for prostate cancer.

Pisipati SV, Pathapati H, Bhukya G, Nuthakki S, Chandu B, Nama S, Adeps R. J Basic Clin Pharm. 2012 Mar;3(2):261-4. Epub 2012 May 15.

54. Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model.

Adhami VM, Siddiqui IA, Syed DN, Lall RK, Mukhtar H. Carcinogenesis. 2012 Mar;33(3):644-51. doi: 10.1093/carcin/bgr308. Epub 2011 Dec 22.

55. Complementary and alternative medicines use by Scottish women with breast cancer. What, why and the potential for drug interactions?

McLay JS, Stewart D, George J, Rore C, Heys SD. Eur J Clin Pharmacol. 2012 May;68(5):811-9. doi: 10.1007/s00228-011-1181-6. Epub 2011 Dec 14.

56. Determination of lignans in edible and nonedible parts of pomegranate (Punica granatum L.) and products derived therefrom, particularly focusing on the quantitation of isolariciresinol using HPLC-DAD-ESI/MSn.

Fischer UA, Jaksch AV, Carle R, Kammerer DR. J Agric Food Chem. 2012 Jan 11;60(1):283-92. doi: 10.1021/jf203598m. Epub 2011 Dec 23.

57. Pomegranate as a functional food and nutraceutical source.

Johanningsmeier SD, Harris GK. Annu Rev Food Sci Technol. 2011;2:181-201.

58. Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia.

Dahlawi H, Jordan-Mahy N, Clench MR, Le Maitre CL. Nutr Cancer. 2012;64(1):100-10.

59. Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.

Afaq F, Katiyar SK. Mini Rev Med Chem. 2011 Dec;11(14):1200-15. Review.

60. Evaluation of antioxidant, antitumor and immunomodulatory properties of polysaccharide isolated from fruit rind of Punica granatum.

Joseph MM, Aravind SR, Varghese S, Mini S, Sreelekha TT. Mol Med Rep. 2012 Feb;5(2):489-96. doi: 10.3892/mmr.2011.638. Epub 2011 Oct 18.

61. Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells.

Nair V, Dai Z, Khan M, Ciolino HP. Anticancer Res. 2011 Sep;31(9):2699-704.

62. The antioxidant potency of Punica granatum L. Fruit peel reduces cell proliferation and induces apoptosis on breast cancer.

Dikmen M, Ozturk N, Ozturk Y. J Med Food. 2011 Dec;14(12):1638-46. doi: 10.1089/jmf.2011.0062. Epub 2011 Aug 23.

63. Pomegranate extract demonstrate a selective estrogen receptor modulator profile in human tumor cell lines and in vivo models of estrogen deprivation.

Sreeja S, Santhosh Kumar TR, Lakshmi BS, Sreeja S. J Nutr Biochem 2012 Jul;23(7):725-32.

64. The bioactivity of pomegranate: impact on health and disease.

Faria A, Calhau C. Crit Rev Food Sci Nutr. 2011 Aug;51(7):626-34.

65. Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines.

Ozbay T, Nahta R. Breast Cancer (Auckl). 2011;5:143-54.

66. In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori.

Hajimahmoodi M, Shams-Ardakani M, Saniee P, Siavoshi F, Mehrabani M, Hosseinzadeh H, Foroumadi P, Safavi M, Khanavi M, Akbarzadeh T, Shafiee A, Foroumadi A. Nat Prod Res. 2011 Jul;25(11):1059-66. doi: 10.1080/14786419.2010.501763.

67. Pomegranate sensitizes Tamoxifen action in ER-α positive breast cancer cells.

Banerjee S, Kambhampati S, Haque I, Banerjee SK. J Cell Commun Signal. 2011 Dec;5(4):317-24. doi: 10.1007/s12079-011-0138-y. Epub 2011 Jun 27.

68. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells.

Wang L, Alcon A, Yuan H, Ho J, Li QJ, Martins-Green M. Integr Biol (Camb). 2011 Jul;3(7):742-54.

69. Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in rats.

Cayır K, Karadeniz A, Simşek N, Yıldırım S, Karakuş E, Kara A, Akkoyun HT, Sengül E. J Med Food. 2011 Oct;14(10):1254-62. doi: 10.1089/jmf.2010.0286. Epub 2011 May 6.

70. Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity.

Jiang J, Eliaz I, Sliva D. Int J Oncol. 2011 Jun;38(6):1675-82.

71. Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs/NF-κB and reduced cell proliferation.

George J, Singh M, Srivastava AK, Bhui K, Shukla Y. Food Chem Toxicol. 2011 Jul;49(7):1511-20. doi: 10.1016/j.fct.2011.03.040. Epub 2011 Apr 2.

72. Nutritional interventions for cancer-induced cachexia.

Gullett NP, Mazurak VC, Hebbar G, Ziegler TR. Curr Probl Cancer. 2011 Mar-Apr;35(2):58-90. doi: 10.1016/j.currproblcancer.2011.01.001. No abstract available.

73. Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.

Bishayee A, Bhatia D, Thoppil RJ, Darvesh AS, Nevo E, Lansky EP. Carcinogenesis. 2011 Jun;32(6):888-96.

74. Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells.

Weisburg JH, Schuck AG, Silverman MS, Ovits-Levy CG, Solodokin LJ, Zuckerbraun HL, Babich H. Anticancer Agents Med Chem. 2010 Oct 1;10(8):634-44.

75. Growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in LNCaP human prostate cancer cells.

Gasmi J, Sanderson JT. J Agric Food Chem. 2010 Dec 8;58(23):12149-56. doi: 10.1021/jf103306k. Epub 2010 Nov 10.

76. Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.

Afaq F, Khan N, Syed DN, Mukhtar H. Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26.

77. [Nutrition, dietary supplements and prostate cancer].

Desgrandchamps F, Bastien L. Prog Urol. 2010 Sep;20(8):560-5.

78. Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro.

Dai Z, Nair V, Khan M, Ciolino HP. Oncol Rep. 2010 Oct;24(4):1087-91.

79. Cancer chemoprevention by pomegranate: laboratory and clinical evidence.

Adhami VM, Khan N, Mukhtar H. Nutr Cancer. 2009;61(6):811-5.

80. Pomegranate and breast cancer: possible mechanisms of prevention.

Sturgeon SR, Ronnenberg AG. Nutr Rev. 2010 Feb;68(2):122-8.

81. Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity.

Tran HN, Bae SY, Song BH, Lee BH, Bae YS, Kim YH, Lansky EP, Newman RA. Endocr Res. 2010 Jan;35(1):1-16. doi: 10.3109/07435800903524161.

82. Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins.

Kasimsetty SG, Bialonska D, Reddy MK, Ma G, Khan SI, Ferreira D. J Agric Food Chem. 2010 Feb 24;58(4):2180-7.

83. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro.

Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Cancer Prev Res (Phila). 2010 Jan;3(1):108-13. doi: 10.1158/1940-6207.CAPR-08-0225.

84. Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation.

Grossmann ME, Mizuno NK, Schuster T, Cleary MP. Int J Oncol. 2010 Feb;36(2):421-6.

85. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling.

Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP. J Agric Food Chem. 2010 Apr 14;58(7):3965-9. doi: 10.1021/jf902857v.

86. Nutraceuticals and prostate cancer prevention: a current review.

Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE. Nat Rev Urol. 2010 Jan;7(1):21-30. doi: 10.1038/nrurol.2009.234. Epub 2009 Dec 8. Review.

87. Apoptosis by dietary agents for prevention and treatment of prostate cancer.

Khan N, Adhami VM, Mukhtar H. Endocr Relat Cancer. 2010 Jan 29;17(1):R39-52.

88. Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.

Kasimsetty SG, Bialonska D, Reddy MK, Thornton C, Willett KL, Ferreira D. J Agric Food Chem. 2009 Nov 25;57(22):10636-44. doi: 10.1021/jf902716r.

89. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice.

González-Sarrías A, Giménez-Bastida JA, García-Conesa MT, Gómez-Sánchez MB, García-Talavera NV, Gil-Izquierdo A, Sánchez-Alvarez C, Fontana-Compiano LO, Morga-Egea JP, Pastor-Quirante FA, Martínez-Díaz F, Tomás-Barberán FA, Espín JC. Mol Nutr Food Res. 2010 Mar;54(3):311-22. doi: 10.1002/mnfr.200900152.

90. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis.

Koyama S, Cobb LJ, Mehta HH, Seeram NP, Heber D, Pantuck AJ, Cohen P. Growth Horm IGF Res. 2010 Feb;20(1):55-62. doi: 10.1016/j.ghir.2009.09.003. Epub 2009 Oct 22.

91. Pomegranate fruit extract impairs invasion and motility in human breast cancer.

Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD. Integr Cancer Ther. 2009 Sep;8(3):242-53. doi: 10.1177/1534735409341405.

92. The role of pomegranate (Punica granatum L.) in colon cancer.

Khan SA. Pak J Pharm Sci. 2009 Jul;22(3):346-8.

93. Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.

González-Sarrías A, Azorín-Ortuño M, Yáñez-Gascón MJ, Tomás-Barberán FA, García-Conesa MT, Espín JC. J Agric Food Chem. 2009 Jun 24;57(12):5623-32.

94. Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity.

Xu KZ, Zhu C, Kim MS, Yamahara J, Li Y. J Ethnopharmacol. 2009 Jun 22;123(2):280-7.

95. Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin.

Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H. Exp Dermatol. 2009 Jun;18(6):553-61.

96. Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.

Saruwatari A, Okamura S, Nakajima Y, Narukawa Y, Takeda T, Tamura H. J Med Food. 2008 Dec;11(4):623-8. doi: 10.1089/jmf.2007.0050.

97. Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats.

Celik I, Temur A, Isik I. Food Chem Toxicol. 2009 Jan;47(1):145-9. doi: 10.1016/j.fct.2008.10.020. Epub 2008 Nov 5.

98. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism.

Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A. Mol Cancer Ther. 2008 Sep;7(9):2662-71. doi: 10.1158/1535-7163.MCT-08-0136. Erratum in: Mol Cancer Ther. 2008 Nov;7(11):3654.

99. Cellular antioxidant activity of common fruits.

Wolfe KL, Kang X, He X, Dong M, Zhang Q, Liu RH. J Agric Food Chem. 2008 Sep 24;56(18):8418-26. doi: 10.1021/jf801381y. Epub 2008 Aug 30.

100. Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.

Pacheco-Palencia LA, Noratto G, Hingorani L, Talcott ST, Mertens-Talcott SU. J Agric Food Chem. 2008 Sep 24;56(18):8434-41. doi: 10.1021/jf8005307. Epub 2008 Aug 22.

101. Spontaneous remission of T lymphoblastic lymphoma.

Ceesay MM, Vadher B, Tinwell B, Goderya R, Sawicka E. J Clin Pathol. 2008 Aug;61(8):955-7.

102. Therapeutic applications of pomegranate (Punica granatum L.): a review.

Jurenka JS. Altern Med Rev. 2008 Jun;13(2):128-44. Review.

103. Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor.

Hong MY, Seeram NP, Heber D. J Nutr Biochem. 2008 Dec;19(12):848-55. doi: 10.1016/j.jnutbio.2007.11.006. Epub 2008 May 13.

104. Multitargeted therapy of cancer by ellagitannins.

Heber D. Cancer Lett. 2008 Oct 8;269(2):262-8.

105. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro.

McDougall GJ, Ross HA, Ikeji M, Stewart D. J Agric Food Chem. 2008 May 14;56(9):3016-23. doi: 10.1021/jf073469n. Epub 2008 Apr 16.

106. Dietary agents for chemoprevention of prostate cancer.

Syed DN, Suh Y, Afaq F, Mukhtar H. Cancer Lett. 2008 Jul 8;265(2):167-76. doi: 10.1016/j.canlet.2008.02.050. Epub 2008 Apr 18. Review.

107. Safety evaluation of an oak-flavored milk powder containing ellagitannins upon oral administration in the rat.

Azorín-Ortuño M, Urbán C, Cerón JJ, Tecles F, Gil-Izquierdo A, Pallarés FJ, Tomás-Barberán FA, Espín JC. J Agric Food Chem. 2008 Apr 23;56(8):2857-65.

108. Ellagic acid, pomegranate and prostate cancer -- a mini review.

Bell C, Hawthorne S. J Pharm Pharmacol. 2008 Feb;60(2):139-44. Review.

109. Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease.

Seeram NP. J Agric Food Chem. 2008 Feb 13;56(3):627-9.

110. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo.

Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM, Henning SM, Firouzi A, Rettig MB, Aronson WJ, Pantuck AJ, Heber D. Int J Oncol. 2008 Feb;32(2):475-80.

111. Pomegranate juice effects on cytochrome P450S expression: in vivo studies.

Faria A, Monteiro R, Azevedo I, Calhau C. J Med Food. 2007 Dec;10(4):643-9.

112. Cancer chemoprevention through dietary antioxidants: progress and promise.

Khan N, Afaq F, Mukhtar H. Antioxid Redox Signal. 2008 Mar;10(3):475-510. Review.

113. Can pomegranate prevent prostate cancer?

Pereira M. J Cancer Res Ther. 2007 Jul-Sep;3(3):166. No abstract available.

114. Current status and future perspectives of chemoprevention in head and neck cancer.

Klass CM, Shin DM. Curr Cancer Drug Targets. 2007 Nov;7(7):623-32. Review.

115. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans.

Espín JC, González-Barrio R, Cerdá B, López-Bote C, Rey AI, Tomás-Barberán FA. J Agric Food Chem. 2007 Dec 12;55(25):10476-85. Epub 2007 Nov 9.

116. Anti-oxidants from green tea and pomegranate for chemoprevention of prostate cancer.

Adhami VM, Mukhtar H. Mol Biotechnol. 2007 Sep;37(1):52-7. Review.

117. Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland.

Seeram NP, Aronson WJ, Zhang Y, Henning SM, Moro A, Lee RP, Sartippour M, Harris DM, Rettig M, Suchard MA, Pantuck AJ, Belldegrun A, Heber D. J Agric Food Chem. 2007 Sep 19;55(19):7732-7. Epub 2007 Aug 28.

118. Pomegranate derived products for cancer chemoprevention.

Syed DN, Afaq F, Mukhtar H. Semin Cancer Biol. 2007 Oct;17(5):377-85.

119. Pomegranates for the prostate and the heart: seeds of hope.

[No authors listed] Harv Mens Health Watch. 2007 Apr;11(9):4-5. No abstract available.

120. Prevention of prostate cancer through custom tailoring of chemopreventive regimen.

Siddiqui IA, Afaq F, Adhami VM, Mukhtar H. Chem Biol Interact 20080;171(2):122-32.

121. Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.

Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H. Cancer Res. 2007 Apr 1;67(7):3475-82.

122. Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.

Boateng J, Verghese M, Shackelford L, Walker LT, Khatiwada J, Ogutu S, Williams DS, Jones J, Guyton M, Asiamah D, Henderson F, Grant L, DeBruce M, Johnson A, Washington S, Chawan CB. Food Chem Toxicol. 2007 May;45(5):725-32. Epub 2006 Nov 10.

123. In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin.

Kulkarni AP, Mahal HS, Kapoor S, Aradhya SM. J Agric Food Chem. 2007 Feb 21;55(4):1491-500. Epub 2007 Jan 23.

124. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer.

Lansky EP, Newman RA. J Ethnopharmacol. 2007 Jan 19;109(2):177-206. Review.

125. Polyphenols from green tea and pomegranate for prevention of prostate cancer.

Adhami VM, Mukhtar H. Free Radic Res. 2006 Oct;40(10):1095-104. Review.

126. Clinical trials of natural products as chemopreventive agents for prostate cancer.

Bemis DL, Katz AE, Buttyan R. Expert Opin Investig Drugs 2006;15(10):1191-200. Review.

127. Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice.

Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. Carcinogenesis. 2007 Jan;28(1):163-73. Epub 2006 Aug 18.

128. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging.

Afaq F, Mukhtar H. Exp Dermatol. 2006 Sep;15(9):678-84. Review.

129. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.

Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram M, Ignarro L, Belldegrun A. Clin Cancer Res. 2006 Jul 1;12(13):4018-26.

130. Molecular targets of dietary agents for prevention and therapy of cancer.

Aggarwal BB, Shishodia S. Biochem Pharmacol. 2006 May 14;71(10):1397-421. Review.

131. Role of vitamins, minerals and supplements in the prevention and management of prostate cancer.

Santillo VM, Lowe FC. Int Braz J Urol. 2006 Jan-Feb;32(1):3-14. Review.

132. Phase-II Study of pomegranate juice for men with prostate cancer and increasing PSA.

Pantuck AJ, Zomorodian N, Belldegrun AS. Curr Urol Rep. 2006 Jan;7(1):7. No abstract

133. Prostate cancer prevention through pomegranate fruit.

Malik A, Mukhtar H. Cell Cycle. 2006 Feb;5(4):371-3. Epub 2006 Feb 15.

134. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.

Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. J Agric Food Chem. 2006 Feb 8;54(3):980-5.

135. The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.

Larrosa M, Tomás-Barberán FA, Espín JC. J Nutr Biochem. 2006 Sep;17(9):611-25.

136. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells.

Jeune MA, Kumi-Diaka J, Brown J. J Med Food. 2005 Winter;8(4):469-75.

137. Pomegranates may combat prostate cancer.

[No authors listed] Health News. 2005 Nov;11(11):2. No abstract available.

138. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.

Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14813-8.

139. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice.

Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. J Nutr Biochem. 2005 Jun;16(6):360-7.

140. New developments in the realm of complementary medicine.

[No authors listed] J Support Oncol. 2005 May-Jun;3(3):238-40, 245-6. No abstract available.

141. Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel.

Lansky EP, Harrison G, Froom P, Jiang WG. Invest New Drugs. 2005 Mar;23(2):121-2. Erratum in: Invest New Drugs. 2005 Aug;23(4):379.

142. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.

Aggarwal BB, Shishodia S. Ann N Y Acad Sci. 2004 Dec;1030:434-41. Review.

143. The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract.

Ajaikumar KB, Asheef M, Babu BH, Padikkala J. J Ethnopharmacol 2005;96(1-2):171-6.

144. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture.

Mehta R, Lansky EP. Eur J Cancer Prev. 2004 Aug;13(4):345-8.

145. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions.

Lansky EP, Jiang W, Mo H, Bravo L, Froom P, Yu W, Harris NM, Neeman I, Campbell MJ. Invest New Drugs. 2005 Jan;23(1):11-20.

146. Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign.

Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H. Photochem Photobiol. 2005 Jan-Feb;81(1):38-45.

147. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.

Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H. Int J Cancer 2005;113(3):423-33.

148. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells.

Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman I, Geldof AA, Campbell MJ. J Med Food. 2004 Fall;7(3):274-83.

149. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats.

Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Cancer Sci. 2004 Jun;95(6):481-6.

150. Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells.

Kawaii S, Lansky EP. J Med Food. 2004 Spring;7(1):13-8.

151. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo.

Toi M, Bando H, Ramachandran C, Melnick SJ, Imai A, Fife RS, Carr RE, Oikawa T, Lansky EP. Angiogenesis. 2003;6(2):121-8.

152. Cancer: how not to go there. The secret to cancer prevention may be in the gym. Or in the spice rack. Let's hope researchers find it soon.

[No authors listed] Harv Health Lett. 2004 Jan;29(3):4. No abstract available.

153. Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry.

van Elswijk DA, Schobel UP, Lansky EP, Irth H, van der Greef J. Phytochemistry. 2004 Jan;65(2):233-41.

154. Chemoprevention: eat ginger, rub on pomegranate.

Burton A. Lancet Oncol. 2003 Dec;4(12):715. No abstract available.

155. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice.

Hora JJ, Maydew ER, Lansky EP, Dwivedi C. J Med Food. 2003 Fall;6(3):157-61.

156. The pomegranate: nature's power fruit?

Longtin R. J Natl Cancer Inst. 2003 Mar 5;95(5):346-8. No abstract available.

157. Plant antimutagens and their mixtures in inhibition of genotoxic effects of xenobiotics and aging processes.

Alekperov UK. Eur J Cancer Prev. 2002 Aug;11 Suppl 2:S8-11.

158. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer.

Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachandran C, Rabi T, Kaplan B, Lansky E. Breast Cancer Res Treat. 2002 Feb;71(3):203-17.

159. Papillary eccrine adenoma with a pomegranate-like appearance.

Ambo M, Kumakiri M, Kobayashi H, Ohkawara A. J Dermatol. 1997 Dec;24(12):773-6.

160. Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro.

Settheetham W, Ishida T. Southeast Asian J Trop Med Public Health. 1995;26 Suppl 1:306-10.

161. Food habits and esophageal cancer: an overview.

Ghadirian P, Ekoé JM, Thouez JP. Cancer Detect Prev. 1992;16(3):163-8. Review.

162. Food habits of the people of the Caspian Littoral of Iran in relation to esophageal cancer.

Ghadirian P. Nutr Cancer. 1987;9(2-3):147-57.

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