EXOGENOUS AGENTS
Cannabis arteritis – acral toe-tip necrosis
BJD 152:166–169,
2005; Arch Mal Coeur 53:143–147, 1960
Radial or ulnar artery catherization
Hand Surg 4:151–157, 1999
Mitten thread
JAMA 248:924–925, 1982
Silica-associated systemic sclerosis
BJD 123:725–734, 1990
INFECTIONS AND INFESTATIONS
Acute bacterial endocarditis
Anthrax – eschar of the fingers, face, or neck
Cutis 67:488–492,
2001; Clin Inf Dis 19:1009–1014, 1994; Cutis 48:113–114,
1991; Cutis 40:117–118, 1987
Aspergillosis – primary cutaneous
JAAD 31:344–347, 1994
Cowpox
Tyring p.52, 2002
Eikenella corrodens – felon with fingertip necrosis
Diabetes
Care 19:1011–1013, 1996
Epidemic typhus
(Rickettsia prowazeki ) – pink macules on
sides of trunk, spreads centrifugally; flushed face with injected
conjunctivae; then rash becomes deeper red, then purpuric;
gangrene of finger, toes, genitalia, nose
JAAD 2:359–373, 1980
Felon with fingertip necrosis
Diabetes Care 19:1011–1013, 1996
Hepatitis C – with cryoglobulins; thrombotic vasculitis
AD
131:1185–1193, 1995
Herpes simplex virus in AIDS
HIV
AD 131:357–358, 1995; polyarteritis nodosa-like lesions
J Clin Inf Dis 23:659–661, 1996
Meningococcemia
Curr Prob Dermatol 14:183–220, 2002
Mucormycosis
Osteomyelitis
Pasteurella canis due to dog bite JAAD 46:S151–152, 2002
Rocky Mountain spotted fever
(Rickettsia rickettsii) – initially
blanching pink macules, or morbilliform eruption of wrists and
ankles; soon spreads to face, trunk, and extremities; palms and
soles involved; becomes purpuric with acral gangrene
JAAD
2:359–373, 1980
Septic emboli
Snakebite – African puff adder
J Emerg Med 15:827–831, 1997
METABOLIC
Anti-thrombin III deficiency
Calcinosis cutis – metastatic calcification; calciphylaxis
JAAD 45:35–361, 2001; Arch Int Med 136:1273–1280, 1976
Cryofibrinogenemia
Cryoglobulinemia
Arthritis Rheum 42:1051–1955, 1999
Diabetes mellitus – micrangiopathy; neuropathic ulcers;
pseudoainhum in diabetics
Caputo p.189, 2000
Factor V Leiden deficiency, heterozygous
BJD 143:1302–1305,
2000
Functionally abnormal plasminogen
Hyperhomocysteinemia – distal cutaneous necrosis
Ann DV
126:822–825, 1999
Hyperviscosity – acral finger/toe-tip necrosis
BJD 152:166–169,
2005
Oxalosis, primary – alanine glyoxalate aminotransferase
deficiency
JAAD 46:S16–18, 2002; AD 136:1272–1273, 2000;
JAAD 22:952–956, 1990; AD 131:821–823, 1995
Polycythemia vera
Protein C or S deficiency
Thrombocythemia
Leuk Lymphoma 22 Suppl 1:47–56, 1996
Waldenström’s macroglobulinemia
NEOPLASTIC
Gamma heavy chain disease
JAAD 23:988–990, 1990
Lymphoma – cutaneous T-cell lymphoma with gangrene
JAAD 23:1169–1170, 1990; angiocentric lymphoma BJD
142:1013–1016, 2000
Metastatic carcinoma – gastric, breast lung, kidney, colon
JAAD 27:117–118, 1992
Myeloid metaplasia
Ann Surg 193:453–461, 1981
Polycythemia vera
Thrombocythemia
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