Schneiderman Prelims Vol-I. qxd

INFLAMMATORY DISEASES
Crohn’s disease – metastatic 
Clin Exp Dermatol 21:318–319,
1996
Cullen’s sign – periumbilical purpura; acute pancreatitis,
ruptured ectopic pregnancy, perforated duodenal ulcer
Rook p.3165, 1998, Sixth Edition; Br Med J i:154, 1971
Deep umbilicus – purulent umbilical drainage
JAAD 44:687–688, 2001
Endometriomas (32% of all umbilical tumors, most common);
cutaneous endometrioma 
J Derm Surg 20:693–695, 1994;
South Med J 70:147–152, 1977; AD 112:1435–1436, 1976;
JAMA 191:167, 1965 Erythema multiforme
Funisitis – inflammation of the umbilical cord or stump;
increased secretions and/or foul odor 
Textbook of Neonatal
Dermatology, p.184, 2001
Pilonidal sinus of umbilicus (hair sinus) – pain, tenderness, and
discharge in hirsute men 
Cutis 62:83–84, 1998; J Fam Pract
29:205–209, 1989
Hidradenitis suppurativa
Necrotizing fasciitis, retroperitoneal – periumbilical
erythema 
JAAD 53:527–528, 2005; Crit Care
Med 29:1071–1073, 2001
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Omphalitis – periumbilical erythema 
JAAD 53:527–528, 2005;
Scand J Gastroenterol 39:1021–1024, 2004
Pilonidal granulomata
METABOLIC DISEASES
Angiokeratoma corporis diffusum (Fabry’s disease
(
α
-galactosidase A) – X-linked recessive; periumbilical rosette
NEJM 276:1163–1167, 1967; fucosidosis (
α
1
-fucosidase)
AD 107:754–757, 1973; Kanzaki’s disease
(
α
-
N-acetylgalactosidase) AD 129:460–465, 1993;
aspartylglycosaminuria (aspartylglycosaminidase) 
Paediatr Acta
36:179–189, 1991; umbilical hernia Clin Genet 23:427–435,
1983 adult-onset GM1 gangliosidosis (
β
-galactosidase)
Clin Genet 17:21–26, 1980; galactosialidosis (combined
β
-galactosidase and sialidase) 
AD 120:1344–1346, 1984; no
enzyme deficiency) – telangiectasias or small angiokeratomas
Cirrhosis – ulceration of umbilical vein; umbilical hemorrhage
Postgrad Med 57:461–462, 1981
Colonic mucosa implantation – umbilical nodule 
BJD 90:108, 1974
Cretinism – coarse facial features, lethargy, macroglossia, cold
dry skin, livedo, umbilical hernia, poor muscle tone, coarse
scalp hair, synophrys, no pubic or axillary hair at puberty 
Rook
p.2708, 1998, Sixth Edition
Cullen’s sign
Mannosidosis – umbilical hernia 
Johns Hopkins Med
J 151:113–117, 1982
Pruritic urticarial papules and plaques of pregnancy (PUPPP) 
Stein–Leventhal syndrome (polycystic ovarian disease)