Systemic lupus erythematosus and rheumatoid arthritis

Renal disorder No renal disorder P-value
1
OR
 
95% CI
 
(n=86) n, (%) 
(n=174) n, (%) 
AA 
2 (2.3) 
0 (0.0) 
NA 
NA 
NA 
AG 
17 (19.8) 
17 (9.8) 
0.040 
2.28 1.10-4.72 
GG 
67 (77.9) 
157 (90.2) 
0.004 
0.38 0.19-0.78 
A carrier 
19 (22.1) 
17 (9.8) 
0.012 
2.62 1.28-5.35 
G carrier 
84 (97.7) 
174 (100.0) 
0.206 
3.07 2.58-3.66 
A allele 
0.122 
0.049 
0.005 2.71 
1.32-5.55 
1
The P-values are calculated using Yates correction. NA = not applicable 
The role of the 
PD1.3
risk allele was further elucidated and multiple binary 
regression models, adjusted for sex and age at disease onset, were constructed in 
which the risk allele was related to signs of renal disorder from the ACR 
criteria, SLICC/ACR damage index, and SLEDAI score. In all models the 
PD1.3A
allele was significantly associated with renal disorder (Figure 12). 
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Figure 12.
Regression analyses of patients with renal disorder. The 
PD-1.3A
allele was used as 
independent variable and all models were adjusted for sex and age of disease onset. SLEDAI (1) 
= Proteinuria, haematuria, pyuria and casts were combined into one dependent variable, SLEDAI 
(2) = Proteinuria alone as the dependent variable. Results are presented as odds ratios and the 
PD-
1.3A
allele was significantly associated with all measures of renal disorder.