Immune determinants of covid-19 disease presentation and severity

Document Outline

• Immune determinants of COVID-19 disease presentation and severity
  • COVID-19 disease courses
    • Mild and severe acute COVID-19. 
    • Long COVID. 
    • Multisystem inflammatory syndrome associated with COVID-19. 
  • Viral recognition and innate immune responses
    • Viral entry. 
    • Innate immune responses. 
  • Adaptive immune responses
  • Known immunological differences between high- and low-risk individuals
    • Sex differences. 
    • Age differences. 
    • Immunodeficiencies. 
    • Future directions. 
  • Acknowledgements
  • Fig. 1 Coronavirus recognition and immune response.
  • Fig. 2 Immune-system parameters associated with obesity, aging and severe COVID-19.