“ фаол тадбиркорлик, инновацион ғоялар ва технологияларни қЎллаб-қувватлаш йили”

Objectives: A comparative study of the toxic properties of anthelmintic drugs. 
Materials and methods: We have studied the commonly used drugs that lead to poisoning. 
Wormil is an anthelmintic preparation with a wide spectrum of action. The active substance is 
albendazole. Albendazole is effective in the tissue and intestinal forms of parasitic diseases. It 
works both on adult helminths, and on their larvae and eggs. The anthelmintic effect is due to the 
ability of albendazole to suppress the polymerization of tubulin, which causes a disturbance in the 
metabolism of helminths with their further death. Exhibits activity against intestinal helminths 
(nematodes Enterobiusvermicularis, Ascarislumbricoides, Trishiurustrishiura, 
Strongiloidesstercoralis, Necatoramericanus, Cutaneous Larva Migrans Ancylostomaduodenale; 
cestodes Taeniasolium, Hymenolepsisnana, Taeniasaginata; Clonorchissinensis trematodes and 
Opisthorhisviverrini), as well as protozoa (Giardialamblia). After internal administration, 

---

albendazole from the gastrointestinal tract is absorbed poorly - up to about 5%. With the 
simultaneous use with albendazole of fatty foods, an increase in the absorption of the substance is 
observed. At the primary passage through the liver is rapidly metabolized. The main metabolite, 
albendazole sulfate, is active at 50% of the action of the primary substance. The half-life is 8.5 
hours. Metabolites of albendazole are excreted from the body with bile (predominantly) and urine 
(small amounts). When taken for a long time (in large doses for the treatment of cysts) excretion of 
metabolites from cysts is observed for several weeks. When receiving Worm may occur 
disturbances in the instructions to the drug known side effects include: vomiting, stomatitis, dry 
mouth, heartburn, nausea, flatulence, abdominal pain, constipation, and diarrhea; headaches, 
decreased vision, dizziness, drowsiness, and vice versa - insomnia, seizures, impaired orientation, 
confusion, and even hallucinations. Allergic reactions can develop in the form of hives, dermatitis. 
The consequence of toxic damage is the inhibition of hematopoiesis. The diagnosis may sound like 
pancytopenia, leukopenia. The active substance of Decaris - levamisole is an anthelmintic agent. 
Acting on the ganglion-like formations of nematodes, Decaris causes depolarizing neuromuscular 
paralysis of the membrane of helminth muscles, blocks succinate dehydrogenase, inhibits fumarate 
dehydrogenase, disrupting the course of bioenergetic helminth processes. Thus, paralyzed 
nematodes are removed from the body by normal intestinal peristalsis within 24 hours after taking 
the drug. Decaris increases the level of phenytoin in the blood, so when using them at the same 
time, it is necessary to control the level of phenytoin in the blood. Decaris can not be used 
simultaneously with lipophilic preparations, such as carbon tetrachloride, tetrachlorethylene, 
chanopodium oil, chloroform or ether, since its toxicity can increase. Virtually not absorbed in the 
intestine. T1 / 22.5-5.5 h. More than 90% of the dose is excreted with the feces in unchanged form. 
The absorbed part (5-10%) is excreted by the kidneys. Vermox is used during enterobiasis; 
ascaridosis; ankylostomidosis; strongyloidiasis; trichocephalosis; trichinosis; shadows; 
echinococcosis; alveococcosis; capillariosis;
which causes generalized contraction of parasite muscles, and also inhibits glucose uptake by 
helminth cells, while reducing glycogen levels and stimulating the release of lactic acid compounds. 
As a result, parasites die. Praziquantel is specifically active against trematodes and cestodes. 
Treatment of infections caused by various schistosomes (Schistosomahaematobium, 
Schistosomamansoni, Schistosomaintercalatum, Schistosomajaponicum, Schistosomamekongi); 
Treatment of infections caused by hepatic ligament (Clonorchissinensis, Opistorchisviverrini) and 
pulmonary flukes (including Paragonimuswestermani) low-toxic. 
Results: 
Name of substances 
Most used 
Drug’s have the highest levels of 
poisoning 
Vormil 
Biltricide 
Vermox 
Decaris 
Vermox 
Wormil 
Vermox 
Vormil 
Decaris 
Pyrantel. 
Pirvinia embonate 
Pirvinia embonate 
Piperazine 
Decaris 
Piperazine 
Pirvinia embonate 
Piperazine 
Pirantel 
Birtricide 
Pirantel 
Biltricide.