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Ишнинг мақсади:Ушбу ишда Ўзбекистон иқлим шароитида, очиқ ҳавода ўстирилган C.
roseus
ўсимлигининг илдизқисмидаги индол алкалоидларни ўрганиш.Бунинг учун дастлаб
ўсимлик илдизи намунаси 5 г олиниб экстракция қилинади ва HPLC–ESI-MS/MSусулида
ўрганилади. Сўнгра ўсимликда кўп миқдорда учрайдиган индол алкалоидларини ажратиб
олинади.
Хулоса:Ушбу ишнинг ҳажми катта бўлганлиги сабабли ўсимлик таркибидаги алкалоидларга
тўхталишган қарор қилдик. HPLC–ESI-MS/MSусулида ўрганилганида қуйидаги индол
алкалоидлари борлиги аниқланди:аймалицин, аймалицин изомери, серпентин, серпентин
изомер, виндолинин, виндолинин изомери,таберсонин, катарантин, алстонин11-метокси
виндолин. Булардан аймалицин изомери ва қиндолинин изомери (19S виндолинин) ажратиб
олинди. Олинган алкалоидларнинг монокристаллари ўстирилиб Рентген тузилиш таҳлили-
РТТ ёрдамида ўрганилди. Алклаоидларнинг кристалл тузилиши ўрганилганда аймалицин сув
билан 1:1 нисбатда моногидрат ҳолатда эканлиги аниқланди. Виндолининнинг асос ҳолатда
монокристалларини ўстириш имкони бўлмаганилиги сабабли пикрин кислота билан 1:1
нисбатдамонокристаллари олиб РТТ ўрганилди.
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MS/MS analysis of alkaloids in Catharanthusroseus roots 51 (2010) pp.65–69.
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Chun-Hua Wang, Yu Zhang, Miao-Miao Jiang. Indole alkaloids from the roots of
Catharanthusroseus Chem. Nat. Compound N6, (2013) pp.1010-1011.
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B. Deus-Neumann, J. Stockigt, M.H. Zenk, Radioimmunoassay for the quantitative
determination of catharanthine, Planta Med. 53 (1987) 184–188.
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A.K. Shukla, A.K. Shasany, M.M. Gupta, S.P.S. Khanuja, Transcriptome analysis
inCatharanthusroseus leaves and roots for comparative terpenoidindole alkaloidprofiles, J. Exp.
Bot. 57 (2006) 3921–3932.
7.
N.Abduraximova, P.Kh. Yuldashev, S. Yu. Yun
usov. ИсследованиеалкалоидовVinca
major, V.pubescens and V. rosea structure of majdina. Chem. Nat. Compound, 3, (1965) pp.224-
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INTERMACROMOLECULAR REACTION BETWEEN ETHYL BROMIDE OF
POLYMETHACRYLOYL LUPININE WITH HEPARIN
Khakimova M.
–second-year student
Tashkent Pharmaceutical institute, Tashkent city.
Chair of toxicological, organic and biological chemistry.
Scientific teacher: professor A.
К. Karimov & r.r.nuritdinova
Tricyclic quinazoline alkaloids are widely distributed in nature. Most often they occur in the plant
genus Peganum, Galega, Adhadota, Nitraria, Mackinlaya and others. During 35-40 years at the
Institute of the Chemistry of Plant Substances (ICPS) chemical and biological activity of
quinazoline alkaloids are studied and among of them many biological active compounds are found.
For example, deoxypeganine hydrochloride is used in medicine as anticholinesterase preparation.
Chemical modification of tricyclic quinazoline alkaloids and their derivatives may open very
interesting direction in the field of fundamental science as well as for developing efficient
preparations in agriculture and medicine. Carrying out of targeted investigation opens widely
possibility to develop of novel potentially active compounds with different biological activity.
Modification of 6-substituted deoxyvasicinones in this work we carried out synthesis of initial
compound - 6-aminodeoxyvasicinone (1) by reduction of 6-nitrodeoxyvasicinone with SnCl
2
. It is
important to note that the 6-aminoderivative in reactions with aromatic aldehydes, depending on the
reaction conditions (solvent, temperature, reaction time and etc.) can form different products on 6-
NH
2
and 9-CH
2
groups:
N
N
O
H
2
N
N
N
O
N
Ar
N
N
O
H
N
Ar
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