Miroshnichenko qxd

BIOMARKERS IN THE MODERN MEDICAL AND BIOLOGIC PRACTICE
I.I. Miroshnichenko, S.N. Ptitsina
Mental Health Research Center Russian Academy of Medical Science, Kashirskoe Sh., 34, Moscow,
115522 Russia; tel.: [phone]; e-mail [e-mail]
The lecture deals with biomarkers, a newly introduced direction in biomedical research.
The following terms, definitions, and characteristics were proposed to describe biomarkers: diagnostic
tools, clinical endpoints and surrogate endpoints. Examples of predictors for cardiovascular diseases,
acute-phase of inflammation and malignant tumors are represented. The special attention is given to the
characteristic of the widespread biomarkers: homocysteine, transthyretin and C-reactive protein. Modern
methods of identification, qualitative and quantitative determination of biomarkers are considered: mass
spectrometric methods, immunoassay. The relationships between the latest achievements in the field of
genomics, proteomics, bioinformatics and biomarker’s investigations are established. The perspectives of
biomarkers are discussed.
Key words: 
biomarker, proteomics, homocysteine, mass spectrometry, pharmacogenetics.
БИОМАРКЕРЫ В СОВРЕМЕННОЙ МЕДИКО-БИОЛОГИЧЕСКОЙ ПРАКТИКЕ
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