One’s (own) flesh and blood: your family’s members or relatives.
You have to be nice to your siblings. They are your own flesh and blood.
The young man is my own flesh and blood.
Out of the question: impossible.
I’m afraid a promotion is out of the question now.
It is out of the question to digest his theory.
(to be) out of practice: no longer good at doing something because you have
not been doing it regularly.
If you don’t play guitar regularly, you can soon get out of practice.
She is out of practice at dancing. It’s likely that she won’t dance well tonight.
On the mark: correct.
In my opinion, all the things that he said were right on the mark.
His speech was on the mark.
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