Irrigation

Chlorhexidine (CHX)

• In direct contact with human cells, CHX is cytotoxic; a comparative study using fluorescence assay on human PDL cells showed corresponding cytotoxicity with 0.4% NaOCl and 0.1% CHX.
• Chang et al.(2001)

Chlorhexidine (CHX)

• It has a wide antimicrobial spectrum and is effective against both Gram-positive and Gram-negative bacteria as well as yeasts, while mycobacteria and bacterial spores are resistant to CHX (Shaker et al 1988, Russell AD. 1996).
• CHX is not considered to be an effective antiviral agent, , and its activity is limited to lipid-enveloped viruses (Park JB & Park NH. 1989).
• In direct contact with human cells, CHX is cytotoxic; a comparative study using fluorescence assay on human PDL cells showed corresponding cytotoxicity with 0.4% NaOCl and 0.1% CHX ( Chang et al. 2001).