Март-Апрель 2021
ДИСТАНЦИОННЫЕ ВОЗМОЖНОСТИ И ДОСТИЖЕНИЯ НАУКИ
MEDICAL SCIENCES
THROMBOMODULIN AS A COFACTOR FOR TAFI AND PROTEIN C
ACTIVATION: ROLE IN BREAST CANCER METASTATIC BEHAVIOURS AND
ANGIOGENIC POTENTIAL
Mamazulunov Nurmuxammad
Assistant of Andijan State Medical Institute
Telefon: +998(99) 839 98 80
Abstract: Metastasis is an important process in cancer progression. This process is facilitated
by proteases that promote extracellular matrix degradation and cell invasion. Angiogenesis is
important to the metastatic process and also involves degradation of the extracellular matrix and
cell invasion. Thrombomodulin (TM) has been shown to be an anti-metastatic factor in various
cell types. The anti-metastatic effects of TM have been attributed to its thrombin binding domain,
which is responsible for the activation of TAFI and protein C.
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