Dermatovenerologiya va estetik tibbiyot

Frequency of distribution of alleles and genotypes of Arg25Pro polymorphism in the TGFb1 
gene in groups of patients with vitiligo and control
№
group
allele frequency
genotype distribution frequency
arg
Pro
Arg/Arg
Arg/Pro
Pro/Pro
n
%
n
%
n
%
n
%
n
%
1
main group 
n 
= (104)
67
64,4
28
27,0
9
8,0
Frequency of distribution of alleles and genotypes of G308A polymorphism in TNF 
gene in groups of patients with vitiligo and control
№
group
allele frequency
genotype distribution frequency
g
a
G/G
G/A
A/A
n
%
n
%
n
%
n
%
n
%
1
main group 
n
=(104)
70
67
34
32
0
0
molecular genetic PCr study of lesions revealed 
the molecular genetic PCr study of lesions revealed 
the TGF-ß gene in 67/104 patients – 64,4 % – arg/
arg. 27 % – arg/Pro. 8,0 % and Pro/Pro. TnF-ɑ gene 

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7
тезисы
in 70/104 patients – 67 % – G/G. 32 % – G/a.0 % 
and a/a.
Conclusions: 
Based on the data of collected and 
analyzed by our researchers, it can be assumed that 
vitiligo is controlled polygenically, indirect evidence 
of which is the high frequency of transmission of 
signs in generations. at the same time, multiple 
polymorphism cannot be ruled out, since the disease 
is characterized by clearly