Conference proceedings

SYNTHESIS AND BIOACTIVITY OF NOVEL RHODANIDE COMPOUNDS
1
Department of Biotechnology, Faculty of Science, 74100-Bartin University, 
Bartin, Tukey 
[e-mail] 
2
Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives, ANAS, 
1029, Baku, Azerbaijan 
[e-mail] 
Abstract
. The article is devoted to the targeted synthesis and application of new rhodanides and their various new derivatives 
as new organic compounds containing polyfunctional sulfur and nitrogen atoms in the molecule. The article found its solution to such 
problems as the synthesis of new derivatives of rhodanides with different functional properties, the determination of their 
physicochemical parameters, the study of the dependence of functional properties on composition and structure, and in particular, the 
mechanism of functional influence. Molecular docking results have shown that the most active compounds have binding affinity with 
-4.423, -6.204, -6.623, and -6.298 kcal/mol against hCA I, hCA II, AChE, and α-glycosidase enzyme, respectively. Isocyanotio moiety 
specifically inhibited hCA I and hCA II enzymes.
Keywords
: rhodanides; aziridine; enzymes inhibition. 
In this study, taking into account all of the above, as well as in the continuation of in the field of synthesis of 
various classes of organosulfur compounds, determining the relationship between their structure and antioxidant 
properties, a synthesis of rhodanides (E-1-E-3) of various structures was carried out by a known method and their various 
functional properties have been studied. New heterocyclic derivatives of rodanides have been synthesized by us. In the 
first step, 2-(isosyanothiometyl)-1-(phenylsulfonyl) aziridine was obtained from the action of potassium rodanide with 2-
(chloromethyl)-1-(phenylsulfonyl)aziridine (E1). At the same time, butyl-3-(isocyanotio)-2-(phenylsulfon-amido) (E2) 
was obtained from the interaction of potassium rodanid with butyl-3-chloro-2-(phenylsulfonamido) propanoate. In the 
next step, butyl-3-(isocyanotio)-4,6-dimethyl-1-(phenylsulfonyl) piperidine reacts with butyl-3-(isocyanotio)-2-
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