Bachelor degree

Basics of pharmacology genetics

Module level, if applicable	Module of Individual Educational Trajectory 4: "Genetics technology"
Code, if applicable	BFG 4509
Subtitle, if applicable	not applicable
Courses, if applicable	Course		Credits
	Basics of pharmacology genetics		3
			2 lectures + 1 lab / week
Semester(s) in which the module is taught	7 semester
Person responsible for the module	PhD, Assoc. Prof. Dzhangalina E.D.
Lecturer	PhD, Assoc. Prof. Dzhangalina E.D., PhD, Assist. Prof. Zhussupova A.I.
Language	Kazakh, Russian, English
Relation to curriculum	(State/Social/ Vocational/IET) IET
Type of teaching, contact Hours	Lecture	Practicum		Seminars
	30 hours per semester (2 hours per week)	15 hours per semester (1 hour per week)		-
Workload	Lectures	Guided self-study		Self-study
	30 hours per semester (2 hours per week)	15 hours per semester (1 hour per week)		60 hours per semester (4 hours per week)
Credit points	3 credits= 5 ECTS
Requirements according to the examination regulations	Understand the nature of diseases and drug effects, the dependence of reactions to drugs on hereditary factors and to introduce the methods of molecular diagnostics.
Recommended prerequisites	GMG 2412 General and molecular genetics
Module objectives/intended learning outcomes	Knowledge	Skills		Competences
	History, subject and tasks of pharmacogenetics as a science, ethical, legal and social aspects of genetic tests. Remember: how to identify high genetic risk for multifactorial diseases; Understand: pharmacodynamic and pharmacokinetic mechanisms of the sensitivity of the individual organism to drugs.	Methods for study of pharmacogenetics of drugs and their components. Apply: skills to diagnose the most common form of hereditary diseases; Analysis: dependence of reactions to drugs on hereditary factors.		Ability to design experiments and conduct research on pharmacology genetics with the latest techniques. Evaluate: the methods of a medication for typing, using which an individual can be attributed to a particular phenotype metabolism; Create: experiments as part of pharmacogenetic research.
Content	The course will contain the following topics:
	Basics of pharmacology genetics: 1. History, subject and tasks of pharmacogenetics as a science. 2. Pharmacogenetic research I phase of biotransformation. 3. Pharmacogenetic research II phase of biotransformation. 4. Pharmacogenetic research transporters of medicines. 5. The clinical significance of pharmacodynamic polymorphisms. 6. Pharmacogenetics of anticoagulants. 7. Pharmacogenetics of β-adrenoblockers. 8. Pharmacogenetics ARB II. 9. Pharmacogenetics of antiplatelet agents 10. Pharmacogenetics of drugs used in rheumatology. 11. Pharmacogenetics of statins. 12. Pharmacogenetics of drugs, acting on the central nervous system. 13. Pharmacogenetics of antibiotics. 14, 15. Ethical, legal and social aspects of genetic tests.
Study and examination requirements and forms of examination	1^st interim control: attendance, in-class discussion, problem solving, testing 2^nd interim control: attendance, in-class discussion, problem solving, testing Final examination: written, 2 theoretical questions, 1 practical question
Media employed	Flash and ppt presentations
Reading list	References (in English):