Smallpox Presentation

US Smallpox Vaccination

• Center for Food Security and Public Health Iowa State University - 2004

• Terrorist threats upon US real
• Bush recommends vaccinating healthcare and military personnel
• December 2002
• Jan 2003, CDC ships vaccine and needles to the states
• Nov 2003, 38,908 civilians in 50 states and 526,677 military vaccinated

Who Should Not Get the Vaccine?

• Center for Food Security and Public Health Iowa State University - 2004

• Eczema or atopic dermatitis
• Skin conditions
• Chickenpox, herpes, psoriasis, shingles
• Weakened immune system
• Transplant, chemotherapy, HIV, others
• Pregnant women
• Less than 18yr.
• Breastfeeding mothers
• If exposed, get vaccine no matter what

Adverse Vaccine Reactions

• Center for Food Security and Public Health Iowa State University - 2004

• Prior to 2003 vaccination campaign
• For every 1 million people vaccinated
• 1,000 serious reactions
• 14-52 life-threatening reactions
• 1-2 deaths
• Vaccinia immune globulin (VIG)
• Effective treatment for serious or life-threatening reactions to the vaccine
• IV form, Investigational new drug

Serious Vaccine Reactions

• Center for Food Security and Public Health Iowa State University - 2004

• Inadvertent inoculation
• A vaccinia rash or sores in one area
• Generalized vaccinia
• Widespread vaccinia rash or sores
• Erythema multiforme
• Toxic or allergic reaction

Life Threatening Vaccine Reactions

• Center for Food Security and Public Health Iowa State University - 2004

• Progressive vaccinia (vaccinia necrosum)
• Ongoing skin infection
• Common in immunocompromised
• Virus continues to grow
• Vaccinia immune globulin necessary
• Without it = death