Epilepsy and epileptic syndrome


Scheme of raising the dose of lamotrigine



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Scheme of raising the dose of lamotrigine




1-2 week

3-4 week

5 week

6 week

7 week


25 mg

once a day



25 mg

twice a day



50 mg twice a day

100 mg twice a day

200 mg twice a day


Note: Once the daily dose of the drug reaches the optimal level, it is maintained at the same dose. While the optimal daily dose for some patients is 200 mg, for some patients it may be necessary to increase it to 400 mg.

Valproates. In prevalent epileptic seizures (including tonic-clonic), the first-line recommended medication is valproate. Valproates are very effective in abscesses, myoclonic and atonic attacks. Therefore, they are also recommended for various "mixed" epileptic seizures. Valproate is widely used in epilepsy, behavioral disorders, febrile seizures, simple and complex focal seizures, primary and secondary prevalent epileptic seizures, manifested by psychomotor phenomena. Valproate can be used as an adjunct in the treatment of thrombotic hyperkinesis in children. These drugs are also recommended as adjunctive medications in manic-depressive psychoses. The most commonly used types of valproate are depakin and convulsive.


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