Deyin Guo, Phd all Publications



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Deyin Guo, PhD
All Publications


  1. Shun Li, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao, Shuliang Chen, Xiaolu Zhao, Cao-Qi Lei, Lin Guo, Yu Chen, Chunmei Li, Eija Jokitalo, Yuxin Yin, Hong-Bing Shu, Deyin Guo* (2015) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology (in press).

  2. Panpan Hou, Shuliang Chen, Shilei Wang, Xiao Yu, Yu Chen, Meng Jiang, Ke Zhuang, Wenzhe Ho, Wei Hou, Jian Huang and Deyin Guo* (2015). Genome editing of CXCR4 by CRISPR/cas9 confers cells resistance to HIV-1 infection. Scientific Reports 2015 Oct 20;5:15577. doi: 10.1038/srep15577.

  3. Mengmeng Qu, Jun Cui, Jun Zhu, Yuhong Ma, Xu Yuan, Jinming Shi, Deyin Guo, Changyong Li (2015) Bone marrow-derived mesenchymal stem cells suppress NK cell recruitmentand activationin polyI:C-induced liver injury. Biochem Biophys Res Commun. 466, 173-9.

  4. Lei Cui, Haiying Wang, Yanxi Ji, Jie Yang, Shan Xu, Xingyu Huang, Zidao Wang, Lei Qin, Po Tien, Xi Zhou, Deyin Guo*, Yu Chen* (2015) The Nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells. Journal of Virology 89, 9029-43.

  5. Yi Wang, Ying Sun, Andong Wu, Shan Xu, Ruangang Pan, Cong Zeng, Xu Jin, Xingyi Ge, Zhengli Shi, Tero Ahola, Yu Chen*, Deyin Guo* (2015) Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology 89, 8416-27.

  6. Andong Wu, Yi Wang, Cong Zeng, Xingyu Huang, Shan Xu, Ceyang Su, Min Wang, Yu Chen*, Deyin Guo* (2015) Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus. Virus Research 208, 56-65.

  7. Mingzhu Zhu, Ting Fang, Shun Li, Kun Meng, Deyin Guo* (2015) Bipartite nuclear localization signal controls nuclear import and DNA binding activity of interferon regulatory factor 3. Journal of Immunology 195, 289-97.

  8. Xing Liu, Ruidong Hao, Shuliang Chen, Deyin Guo, Yu Chen (2015) Inhibition of Hepatitis B Virus by CRISPR/Cas9 System via Targeting the Conserved Regions of Viral Genome. J Gen Virol. 96, 2252-61.

  9. Weijia Cheng, Shiyou Chen, Ruiling Li, Yu Chen, Min Wang, and Deyin Guo (2015) Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosome degradation of N-Myc (and STAT) interactor. Virologica Sinica 30, 153-61.

  10. Xiao Yu, Shuliang Chen, Panpan Hou, Min Wang, Yu Chen, Deyin Guo* (2015) VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability. Biochem Biophys Res Commun. 459, 270-6.

  11. Ruidong Hao, Jing He, Xing Liu, Guozhen Gao, Dan Liu, Lei Cui, Guojun Yu, Wenhui Yu, Yu Chen, Deyin Guo* (2015) Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6. Journal of Virology 89, 4345-55.

  12. Pan W, Wu Z, Wu S, Guo D, Gong X, Po T. (2015) Human immunodeficiency virus coinfection with hepatitis B virus leads to a decrease in extracellular and intracellular hepatitis B antigen. AIDS Res Hum Retroviruses 31, 461-9.

  13. Ye Liu, Jieqiong Zhou, Ji-An Pan, Prudence Mabiala, Deyin Guo (2014) A novel approach to block HIV-1 coreceptor CXCR4 in non-toxic manner. Molecular Biotechnology 56, 890-902.

  14. Dan Liu, Andong Wu, Lei Cui, Ruidong Hao, Yuan Wang, Jing He, Deyin Guo (2014) Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β. PLoS One 9(3): e91658. doi:10.1371/journal.pone.0091658.

  15. Ying Sun, Zidao Wang, Jiali Tao, Yi Wang, Andong Wu, Ziwen Yang, Kaimei Wang, Liqiao Shi, Yu Chen*, Deyin Guo* (2014) Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase. Antiviral Research 104, 156-64.

  16. Xu Jin, Yu Chen, Ying Sun, Cong Zeng, Yi Wang, Jiali Tao, Andong Wu, Xiao Yu, Zhou Zhang, Jie Tian, Deyin Guo* (2013) Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP. Virus Research 176, 45-52.

  17. Shuliang Chen, Xiao Yu, Quan Lei, Lixin Ma, and Deyin Guo* (2013) The SUMOylation of zinc-fingers and homeoboxes 1 by Ubc9 regulates its stability and transcriptional repression activity. Journal of Cellular Biochemistry 114, 2323-33.

  18. Lei Lin, Ying Sun, Baojun Luo, Yi Yang, Xiang He, Wenli Su, Zounan Sun, Deyin Guo, Qingyu Zhu, Jingmei Liu, Guohui Chang (2013) Attenuation of mouse hepatitis virus by deletion of the LLRKxGxKG region of nsp1. PLoS ONE 8(4):e61166. doi:10.1371/journal.pone.0061166.

  19. Guozhen Gao, Xiaoyun Wu, Jieqiong Zhou, Mingfeng He, Johnny J. He* and Deyin Guo* (2013) Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant. Journal of Biological Chemistry 288, 14297-14309.

  20. Yu Chen, Jiali Tao, Ying Sun, Andong Wu, Ceyang Su, Guozhen Gao, Hui Cai, Su Qiu, Yingliang Wu, Tero Ahola, Deyin Guo* (2013) Structure-function analysis of SARS coronavirus RNA cap guanine-N7 methyltransferase. Journal of Virology 87, 6296-305.

  21. Ouyang W, An T, Guo D, Wu S, Tien P. (2013) The Potent Human Immunodeficiency Virus Type 1 (HIV-1) Entry Inhibitor HR212 Blocks Formation of the Envelope Glycoprotein gp41 Six-Helix Bundle. AIDS Res Hum Retroviruses 29, 613-620.

  22. Kang X, Chen X, He Y, Guo D, Guo L, Zhong J, Shu HB. (2012) DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication. Virology 435, 385-394.

  23. Min Ke, Yu Chen, Andong Wu, Ying Sun, Ceyang Su, Hao Wu, Xu Jin, Jiali Tao, Yi Wang, Xiao Ma, Ji-An Pan, Deyin Guo* (2012) Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex. Virus Research 167, 322-328.

  24. Chen J, Wang Y, Guo D, Shen B. (2012) A systems biology perspective on rational design of peptide vaccine against virus infections. Curr Top Med Chem 12, 1310-9.

  25. Zhongfan Deng, Huijuan Yan, Jiajie Hu, Shengwei Zhang, Peng Peng, Qingzhen Liu, Deyin Guo* (2012) Hepatitis C virus replicon sensitizes host cells to TRAIL induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. PLoS ONE 7(5): e37700. doi:10.1371/journal.pone.0037700.

  26. An T, Ouyang W, Pan W, Guo D, Li J, Li L, Chen G, Yang J, Wu S, Tien P. (2012) Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. Antiviral Res. 94, 276-87.

  27. Yang Z, Wu R, Li RW, Li L, Xiong Z, Zhao H, Guo D, Pan Z. (2012) Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections. Virus Res. 165, 61-70.

  28. Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D, Cao Z, Yan H. (2012) Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7. PLoS One 7, e34947.

  29. Peng J, Kong W, Guo D, Liu M, Wang Y, Zhu H, Pang B, Miao X, Yu B, Luo T, Hu Q, Zhou D. (2012) The epidemiology and etiology of influenza-like illness in Chinese children from 2008 to 2010. J Med Virol. 84, 672-8.

  30. Onsam Sin, Prudence Mabiala, Ye Liu, Ying Sun, Tao Hu, Qingzhen Liu, and Deyin Guo (2012) Gene Silencing Efficiency and INF-β Induction Effects of Splicing miRNA 155-Based Artificial miRNA with Pre-miRNA Stem-Loop Structures. Biochemical Genetics 50, 112-21.

  31. Yu Chen, Ceyang Su, Min Ke, Xu Jin, Lirong Xu, Zhou Zhang, Andong Wu, Ying Sun, Zhouning Yang, Po Tien, Tero Ahola, Yi Liang, Xinqi Liu, Deyin Guo* (2011) Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens 7(10): e1002294. doi:10.1371/journal.ppat.1002294.

  32. Liang Y, Zhang Z, Wei H, Hu Q, Deng J, Guo D, Cui Z, Zhang XE. (2011) Aptamer beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living cells. Biosens Bioelectron. 28, 270-6.

  33. Miao Jiang, Pamela Österlund, Peter Sarin, Minna Poranen, Dennis Bamford, Deyin Guo* and Ilkka Julkunen* (2011) Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5'-phosphorylation of RNA molecules. Journal of Immunology 187, 1713-21.

  34. Xiaolu Lu, Ji’an Pan, Jiali Tao, Deyin Guo* (2010) SARS-CoV nucleocapsid protein antagonizes IFN-b response by targeting initial step of IFN-b induction pathway,and its C-terminal region is critical for the antagonism. Virus Genes 42, 37-45.

  35. Tao Hu, Ping Chen, Qiong Fu, Junwei Li, Musarat Ishaq, Li Ma, Deyin Guo* (2010) Comparative studies of various artificial microRNA expression vectors for RNAi in mammalian cells. Molecular Biotechnology 46, 34-40.

  36. Ying Wu, Changzhen Liu, Meiyi Sun, Hexiao Shen, Deyin Guo* and Bin Gao* (2010) A novel specific CTL epitope presentation system for anti-tumor immunity. International Journal of Cancer 126, 2373-86.

  37. Xiaoyun Wu, Musarat Ishaq, Guozheng Gao, Tao Hu, Deyin Guo* (2010) M2 pyruvate kinase enhances HIV-1 transcription from its long terminal repeat. Frontiers in Biology 5, 59-66.

  38. Yu Chen, Hui Cai, Ji’an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo* (2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America 106, 3484-9.

  39. Junwei Li, Musarat Ishaq, Mabiala Prudence, Xiao Xi, Tao Hu, Qingzhen Liu, Deyin Guo* (2009) Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2. Virus Research 144, 123-9.

  40. Tao Hu, Qiong Fu, Ping Chen, Li Ma, Onsam Sin and Deyin Guo* (2009) Construction of an Artificial MicroRNA Expression Vector for Simultaneous Inhibition of Multiple Genes in Mammalian Cells. International Journal of Molecular Sciences 10, 2158-2168.

  41. Pan Tao, Mengcheng Luo, Dandan Zhu, Sanfu Qu, Zhenhua Yang, Meng Gao, Deyin Guo, Zishu Pan (2009) Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice. Viral Immunology 22, 273-81.

  42. Zhiqiang Wu, Fan Yang, Rong Zhao, Lina Zhao, Deyin Guo, Qi Jin (2009) Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in China. Journal of Virological Methods 159, 233-238.

  43. Yaling Yang, Snawar Hussain, Hao Wang, Min Ke, Deyin Guo* (2009) Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus. Virus Genes 39, 10-18.

  44. Ping Chen, Tao Hu, Miao Jiang, Deyin Guo* (2009) Synthesis in E. coli cells and characterization of the active exoribonuclease of severe acute respiratory syndrome coronavirus. Molecular Biology 3, 410-417.

  45. Ke Zhang, Yu Chen, Ji’an Pan, Tero Ahola, Deyin Guo* (2009) Lentiviral vector-derived shRNAs confer enhanced suppression of Semliki forest virus replication in BHK-21 cells compared to shRNAs expressed from plasmids. Biotechnology Letters 31, 501-508.

  46. Tao Hu, Qiong Fu, Ping Chen, Ke Zhang, Deyin Guo* (2009) Generation of a stable mammalian cell line for simultaneous expression of multiple genes by using 2A peptide-based lentiviral vector. Biotechnology Letters 31, 353-359.

  47. Musarat Ishaq, Li Ma, Xiaoyun Wu, Yongxin Mu, Ji’an Pan, Jiajie Hu, Tao Hu, Qiong Fu and Deyin Guo* (2009) The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. Journal of Cellular Biochemistry* 106, 296-305.

  48. Xiaoyun Wu, You Zhou, Ke Zhang, Qingzhen Liu & Deyin Guo* (2008) Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Letters 582, 2155-2160.

  49. Ji’An Pan, Xiaoxue Peng, Yajing Gao, Zhilin Li, Xiaolu Lu, Yingzhao Chen, Musarat Ishaq, Dan Liu, Marta L. DeDiego, Luis Enjuanes and Deyin Guo* (2008) Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication. PLoS ONE 3(10): e3299. doi:10.1371/journal.pone.0003299.

  50. Mengcheng Luo, Pan Tao, Junwei Li, Siyu Zhou, Deyin Guo, Zishu Pan (2008) Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice. Journal of Virological Methods 154, 121-7.

  51. Xiaoyun Wu, Musarat Ishaq, Jiajie Hu, Deyin Guo* (2008) HCV NS3/4A protein activates HIV-1 transcription from its long terminal repeat. Virus Research 135, 155-160.

  52. Musarat Ishaq, Jiajie Hu, Xiaoyun Wu, Qingzhen Liu and Deyin Guo* (2008) Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Molecular Biotechnology 39, 231-238.

  53. Yaling Yang, Quan Wang, Deyin Guo* (2008) A Novel Strategy for Analyzing RNA-Protein Interactions by Surface Plasmon Resonance Biosensor. Molecular Biotechnology 40, 87-93.

  54. Junwei Li, Hui Cai, Qingzhen Liu & Deyin Guo* (2008) Molecular and pathological characterization of two H5N1 avian influenza viruses isolated from wild ducks. Virus Genes 37, 88-95.

  55. Deyin Guo*, Minna-Leena Rajamäki & Jari Valkonen (2008) Protein-protein interactions: the yeast two-hybrid system. Methods in Molecular Biology 451, 421-439.

  56. Zuoxiang Xiao, Yong Xiong, Lindi Tan, Elana Ehrlich, Deyin Guo and Xiao-Fang Yu (2007) Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif. Journal of Molecular Biology 373, 541-550.

  57. Ping Chen, Miao Jiang, Tao Hu, Qingzhen Liu, Xiaojiang S. Chen, Deyin Guo* (2007) Biochemical characterization of exoribonuclease encoded by SARS coronavirus. Journal of Biochemistry & Molecular Biology 40, 649-655.

  58. Xiaoxue Peng, Ji'an Pan, Rui Gong, Yang Liu, Shuli Kang, Huixing Feng, Gang Qiu, Deyin Guo, Po Tien, and Gengfu Xiao (2007) Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein: implication for its fusion mechanism. Journal of Biological Chemistry 282, 381-9.

  59. Snawar Hussain, Ji’an Pan, Jing Xu, Yalin Yang, Yu Chen, Yu Peng, Ying Wu, Zhaoyang Li, Ying Zhu, Po Tien, Deyin Guo* (2006) Identification and characterization of severe acute respiratory syndrome coronavirus subgenomic RNAs. Advances in Experimental Medicine and Biology 581, 85-8.

  60. Zhaoyang Li, Yong Xiong, Yu Peng, Ji’an Pan, Yu Chen, Xiaoyun Wu, Snawar Hussain, Po Tien, Deyin Guo* (2005) Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Letters 579, 3100-6.

  61. Guihong Sun, Mingxiong Guo, Ao Shen, Fanghua Mei, Xiaoxue Peng, Rui Gong, Deyin Guo, Jianguo Wu, Po Tien, Gengfu Xiao (2005) Bovine PrPc directly interacts with B-Crystalline. FEBS Letters 579, 5419-24.

  62. Snawar Hussain, Ji’an Pan, Yu Chen, Yalin Yang, Jing Xu, Yu Peng, Ying Wu, Zhaoyang Li, Ying Zhu, Po Tien, Deyin Guo* (2005) Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. Journal of Virology 79, 5288-95.

  63. Ying Zhu, Mo Liu, Weiguang Zhao, Jianlin Zhang, Xue Zhang, Ke Wang, Chunfang Gu, Kailang Wu, Yan Li, Congyi Zheng, Gengfu Xiao, Huimin Yan, Jiamin Zhang, Deyin Guo, Po Tien and Jianguo Wu (2005) Isolation of virus from a SARS patient and genome-wide analysis of genetic mutations related to pathogenesis and epidemiology from 47 SARS-CoV isolates. Virus Genes 30, 93-102.

  64. Deyin Guo*, Carl Spetz, Mart Saarma & Jari Valkonen. (2003) Two plant proteins, including a novel RING-finger protein, interact with the potyviral multifunctional protein HC-Pro. Molecular Plant-Microbe Interactions 16, 405-410.

  65. Xiao-Dong Li, Tomi P. Mäkelä, Deyin Guo, Rabah Soliymani, Vesa Koistinen, Olli Vapalahti1, Antti Vaheri and Hilkka Lankinen. (2002). Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx. Journal of General Virology 83, 759-766.

  66. Deyin Guo*, Minna-Liisa Rajamäki, Mart Saarma & Jari PT Valkonen. (2001). Towards a protein interaction map of potyviruses: protein interaction matrixes of two potyviruses based on the yeast two-hybrid system. Journal of General Virology 82, 935-939.

  67. Igor Oruetxebarria, Deyin Guo, Andres Merits, Kristiina Mäkinen, Mart Saarma and Jari P. T. Valkonen (2000). Identification of the genome-linked protein in virions of Potato Virus A, with comparison to other members in genus Potyvirus. Virus Research 73, 103-112.

  68. Andres Merits, Oleg N. Fedorkin, Deyin Guo, Natalia O. Kalinina and Sergey Yu. Morozov (2000). Activities associated with the putative replication initiation protein of coconut foliar decay virus, a tentative member of genus Nanovirus. Journal of General Virology 81, 3107-3114.

  69. Päivi Lindholm, Tero Kuittinen, Outi Sorri, Deyin Guo, Andres Merits, Kirsi Törmäkangas and Pia Runeberg-Roos (2000). Glycosylation of phytepsin and expression of dad1, dad2 and ost1 during onset of cell death in germinating barley scutella. Mechanisms of Development 93, 169-173.

  70. Deyin Guo*, Andres Merits & Mart Saarma. (1999). Self-association and mapping of interaction domains of helper component proteinase of potato A potyvirus. Journal of General Virology 80, 1127-1131.

  71. Andres Merits, Deyin Guo, Lilian Järvekülg and Mart Saarma (1999). Biochemical and genetic evidence for interactions between potato A potyvirus encoded proteins P1 and P3 and proteins of the putative replication complex. Virology 263, 15-22.

  72. Andres Merits, Deyin Guo. and Mart Saarma (1998). VPg, coat protein and five non-structural proteins of potato A potyvirus bind RNA in a sequence-unspecific manner. Journal of General Virology 79, 3123-7.

  73. Deyin Guo, Edgar Maiss & Günter Adam (1998). Ilarvirus isolation and RNA extraction. Methods in Molecular Biology 81,171-81.

  74. Deyin Guo, Edgar Maiss, Günter Adam & Rudolph Casper. (1995). Prunus necrotic ringspot ilarvirus: Nucleotide sequence of RNA3 and the relationship to other ilarviruses on coat protein comparison. Journal of General Virology 76, 1073-1079.




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