Ўзбекистон республикаси соғЛИҚни сақлаш вазирлиги тошкент тиббиёт академияси биоорганик ва биологик кимё кафедраси

«Regulation of metabolism and body functions by hormones”
1. Common pathways of regulation and a hierarchy of regulatory systems.
2. Classification of hormones by chemical structure, biological functions and mechanisms of signal transfer.
3. The relationship of the endocrine and nervous systems. Hypothalamic-pituitary system and its effect on other peripheral glands.
4. Synthesis and catabolism of steroid hormones.
5. Regulation of water-salt metabolism.
6. Regulation of calcium-phosphate metabolism.
7. Hormones of local action.
The homeostatic adaptations an organism makes to a constantly changing environment are in large part accomplished through alterations of the activity and amount of proteins. Hormones provide a major means of facilitating these changes. A hormone–receptor interaction results in generation of an intracellular signal that can either regulate the activity of a select set of genes, thereby altering the amount of certain proteins in the target cell, or affect the activity of specific proteins, including enzymes and transporter or channel proteins. The signal can influence the location of proteins in the cell and can affect general processes such as protein synthesis, cell growth, and replication, perhaps through effects on gene expression. Other signaling molecules—including cytokines, interleukins, growth factors, and metabolites—use some of the same general mechanisms and signal transduction pathways. Excessive, deficient, or inappropriate production and release of hormones and of these other regulatory molecules are major causes of disease. Adenylyl cyclase is an integral protein of the plasma membrane, with its active site on the cytoplas-mic face. The association of active G". with adenylyl cyclase stimulates the cyclase to catalyze cAMP synthesis from ATP

2. 2 к. даволаш, тиббий-педагогика, тиббий-профилактика ва стоматология факультетлари учун.

3. Маърузанинг мақсади: Талабаларда модда алмашинуви ва функцияларнинг гормонлар ёрдамида бошқарилишини, гормонлар тузилиши, таъсир механизми ва бужараёнларни бузилиши натижасида келиб чиқадиган касалликлар механизми тўғрисида малумотни шакллантириш.