Ноябрь 2020 18-қисм

Results and discussion:
As a result of preoperative treatment with Perindopril (in an individual 
dose of 10 to 40 mg per day), stabilization of blood pressure was noted at the level of 130-
140 / 80-90 mm Hg in 21 patients. Reduce blood pressure, hypothiazide diuretic was added to 
Perindopril (in an individual dose of 12.5 to 25 mg per day) in 9 patients. Every studied patient, 
had a significant decrease of blood pressure was achieved. Reduction in blood pressure (both 
SBP and DBP) by the end of hospitalization. Highest levels of decreased after therapy. More 
pronounced case was a decrease in blood pressure noted on the background of combination 
Perindopril and hypo thiazide. Pulse blood pressure approached normal values (pulse BP in 
healthy is 40-50 mm Hg) after treatment. Dynamics of change blood pressure with Perindopril 
and its combination with hypo thiazide is shown in table. 1. 
All patients were prepared and operated in a planned manner without intra- and postoperative 
falsities.
Table 1
The dynamics of changes in blood pressure
With paraoperative period against the background of application
perindopril and combinations of perindopril with hypothiazide
Study period
SBP,
mm Hg.
DBP,
mmHg.
Pulse BP,
mmHg.
Before treatment
176,11±19,3
98,58±8,7
77,56±14,52
After 15 days:- perindopril
134,44±9,27*
90±6,9*
52,22±7,19*
- perindopril + hypothiazide
130,19±9,02*
80,4±7,92*
50,73±7,46*
Operational period
141±8,32*
88,51±6,79*
52,38±8,34*
After 5 days after operation: - perindopril
136,41±7,25*
91,32±5,4*
51,57±7,46*
- perindopril + hypothiazide
133,1±8,7*
81,14±8,03*
54,3±5,17*
Note. *
- significance of differences compared with the original my indicators (before treatment), 
p <0.001.

---

57