Тошкент тиббиёт академияси ҳузуридаги илмий даражалар берувчи dsc

G.I Shaykhova 
Chairman of a one-time Scientific Council on awarding 
the degree of Doctor of Science, MD, Professor 
N.J. Ermatov 
Academic secretary of one-time Scientific Council for the 
award of a doctoral degree, MD, associate professor 
M.U.Kulmanova 
Chairman of a one-time seminar at the Scientific Council 
for the award of a doctoral degree, MD, аssociate
professor 

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INTRODUCTION (abstract of PhD thesis) 
The aim of the research work 
is estimation of molecular mechanisms of 
disturbance of oxidative processes in the liver, kidneys and endothelium during the 
development of metabolic syndrome in the experiment and the possibility of their 
correction by chitosan sulfate and its nano form. 
The object of research. 
60 rabbits Chinchilla breed. 
The scientific novelty of the research.
The role of endothelial dysfunction 
disorders in the development of MS has been established for the first time, the 
corrective effect of various forms of chitosan on endothelial dysfunction is shown, 
the effectiveness of chitosan sulfate preparations and nano forms of chitosan 
sulfate in restoring the disturbed functions of blood vessels is proved in 
comparison with the glucophage. 
Pathogenetic mechanisms of disturbance of oxidative processes in the liver 
and kidneys are determined depending on endothelial dysfunction in the 
development of the metabolic syndrome. On the basis of the results obtained, a 
method for correcting the revealed disorders by various forms of chitosan was 
developed. 
The role of disturbance of mitochondrial and microsomal oxidation in the 
liver and kidneys in the development of metabolic syndrome was first established. 
It is shown that the disturbance of these systems in the development of the 
metabolic syndrome has a direct dependence on the dysfunctional state of the 
oxidative, antioxidant and NO-ergic systems. 
For the first time in the experiment, the corrective effect of chitosan 
derivatives on MOS and mitochondrial oxidation of the liver and kidneys in 
metabolic syndrome was studied.