Тезисы titul indd

Material and methods:
Observational cohort study included 205 active duty 
military personnel in Serbian army (average years was 39±5.8). Pearson’s correlation 
coefficient used to test the relationship between hs-CRP and other CVD risk factors.
 
Results and discussion: 
Average of hs-CRP was 1.59±2.87mg/L. Among 
participants, there was 161 (79%) with hs-CRP<2mg/L and 44 (21%) with hs-
CRP>2mg/L. There was an important positive correlation between hs-CRP and age 
(r=0.216, p<0.002), body mass index (r=0.210, p<0.002); Reynolds risk score 
(r=0.380, p<0.001); glucose level (r=0.210, p<0.002); metabolic syndrome (r=0.270, 

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p<0.001); and number of risk factors (r=0.210, p<0.003); as well as negative 
correlation with HDL (r=-0.159, p<0.023). There was no statistically important 
correlation between hs-CRP and cholesterol (r=0.500, p=0.500); LDL (r=0.056, 
p=0.430); triglycerides (r=0.132, p=0.060); systolic blood pressure (r=0.090, 
p=0.200); and diastolic blood pressure (r=0.120, p=0.080).
In population of active duty military personnel in Serbia hs-CRP is not 
corelated with all risk factors for CVD, but it is correlated with number of FRs. 
Measurement of hs-CRP may provide a more comprehensive view of the patient’s 
overall risk profile in the population of military personnel of Serbia. In 11% subjects 
with an LDL value greater than the optimum 3.4mg/L, also hs-CRP is value greater 
than 2mg/L, it would be indicative of pharmacological therapy according to the 
criteria of ACCF/AHA [9]. Studies have shown the direct relationship between hs-
CRP as well as markers such as increasing body mass index, HDL, hypertension, age, 
decreasing HDL and the increase in the incidence rate of CVD [10,11]. In contrast to 
these studies, we found no correlation of hs-CRP with total cholesterol, LDL 
cholesterol, triglyceride and blood pressure values. On the other hand, these risk 
factors are pooled, that is, the number of risk factors correlates with the value of hs-
CRP. The association of hs-CRP with risk for CVD has been described in many 
studies. However, approximately one-third of individuals with 0 or 1 risk factor 
develop CVD and up to 40% of individuals with cholesterol levels below the 
population average die from CVD [12]. We believe that, due to the essentially 
younger population (average 39 years) and less time exposure to risk factors, one of 
the main reasons for the results obtained. This fact is lost by the amplification of the 
FRs, that is, their synergistic action.
Conclusion: 
In our study was shown strong correlation between hs-CRP and 
most risk factors for CVD in active duty military personnel in Serbia.