South Boston Scleroderma and Lupus Health Study Massachusetts Department of Public Health Bureau of Environmental Health January 2010

VI. Conclusions

The observed prevalence of SSc in South Boston appears to be higher than expected. However, the prevalence of SLE in South Boston appears to be consistent with prevalence estimates observed elsewhere and reported in published scientific literature. Incidence rates for both diseases are within ranges reported in the literature, however, the estimates are imprecise and based on a small number of cases over a long time period. The risk factor that demonstrated the most consistency with respect to an increased risk of SSc or SLE was a family history of autoimmune/rheumatic disease. This finding was consistent with the etiologic hypothesis in the epidemiological literature for SSc and SLE that a genetic predisposition may influence the development of these diseases. Based on the results observed in this study, it appears that genetic factors may play a role in disease development in the study population. The ability to detect an association between SSc/SLE risk and environmental exposures in the South Boston area was extremely limited due to low statistical power. However, the lack of an association with environmental exposures is not meant to suggest that environmental factors may not have played a role in the development of SSc and SLE. At this time, research currently underway involving clinical registries may better evaluate the nature of gene-environment interactions and characterize the role of environmental factors.

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