Schneiderman Prelims Vol-I. qxd

FACIAL PAPULES
205
Schneiderman page 200-300.qxd 5/16/2006 6:49 PM Page 205

---

VACTERL syndrome (vertebral anomalies, anorectal
malformations, cardiac defects, tracheo-esophageal fistulae,
renal or radial anomalies, limb malformations) – sporadic
J Pediatr 93:270–273, 1978
Wolf–Hirschhorn (4p deletion) syndrome
(oculocerebrocutaneous syndrome) – growth and mental
retardation with seizures, microcephaly, hypospadius,
cryptorchidism, facial and ear abnormalities, down-turned
mouth with cleft lip and/or palate and short philtrum
Ped Derm 17:391–394, 2000
Differential diagnosis of accessory tragus includes:
Acrochordon
Adnexal tumor
Auricular fistula
Branchial cleft cyst and/or fistula
Cartilaginous remnants
Congenital midline hamartoma
Epidermoid cyst
Hair follicle nevus
Lipoma
Skin tags
Thyroglossal duct cyst
Wattle
Angiomatous nevus
Blueberry muffin baby
Branchial cleft cyst – first branchial remnants; mass or sinus
tract anterior and inferior to ear or parotid 
Ped Clin North
Am 6:1151–1160, 1993
Bronchogenic cyst – skin-colored nodule of chin 
BJD
143:1353–1355, 2000
Congenital midline hamartoma – polypoid nodule of chin 
Ped
Derm 7:199–201, 1990
Congenital vellus hamartoma (hair follicle nevus) – skin-colored
papule of face 
Int J Dermatol 31:578–581, 1992
Dermoid cyst (midline) 
Pediatr Rev 11 (9):262–267, 1990
Encephalocoele – blue nodule 
Pediatr Rev 11 (9):262–267, 1990;
anterior encephalocele – facial nodule 
JAAD 51:577–579, 2004
Lacrimal duct cyst
Meningocoele
Nasal glioma – blue or red nodule 
J Neurosurg 64:516–519.
1986; Pediatr Rev 11 (9):262–267, 1990; papule of nose AD
137:1095–1100, 2001
Neuroblastoma
Rhabdomyosarcoma
Sebaceous hyperplasias of the nose 
Eichenfeld, 2001, p.91
Striated muscle hamartoma (rhabdomyomatous mesenchymal
hamartoma) – skin-colored papules of central face; may be
single or multiple, dome-shaped, pedunculated or filiform 
Ped
Derm 16:65–67, 1999
Systemic hyalinosis
DRUG-INDUCED
BCG vaccination, disseminated – umbilicated facial papules
Ped Derm 18:205–209, 2001; Ped Derm 13:451–454, 1996
Bromoderma
Collagen implants – granulomatous reaction 
Cutis 51:95–98,
1993
Corticosteroids – steroid acne; steroid perioral dermatitis
Cyclosporine – lymphocytic infiltrate 
JAAD 23:1137–1141,
1990; cyclosporine-induced folliculodystrophy (viral associated
trichodysplasia? 
JAAD 50:318–322, 2004) – cobblestoned
follicular facial papules 
JAAD 50:310–315, 2004; sebaceous
gland hyperplasia 
BJD 149:198–200, 2003; Dermatologica
172:24–30, 1986; papules of chin – lymphocytic infiltrate AD
129:794–795, 1993
Drug rash
Erbitux (cetuximab) (epidermal growth factor receptor inhibitor) 
5-fluorouracil, systemic – inflamed actinic keratoses
Iododerma
Pseudolymphoma, drug induced – anticonvulsants 
Rook
p.2401–2402, 1998, Sixth Edition; captopril, enalapril J Clin
Pathol 39:902–907, 1986; atenolol Clin Exp Dermatol
115:119–120, 1990; ACE-inhibitors, amitryptiline Curr Probl
Dermatol 19:176–182, 1990