Schneiderman Prelims Vol-I. qxd

REDUNDANT SKIN
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Schneiderman page 500-600.qxd 5/16/2006 6:51 PM Page 589

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Leprechaunism (Donohue’s syndrome) – decreased
subcutaneous tissue and muscle mass, characteristic facies,
severe intrauterine growth retardation, broad nose, low-set ears,
hypertrichosis of forehead and cheeks, loose folded skin at
flexures, gyrate folds of skin of hands and feet; breasts, penis,
clitoris hypertrophic 
Endocrinologie 26:205–209, 1988
Lipoid proteinosis – rugose forehead 
BJD 151:413–423, 2004;
JID 120:345–350, 2003; BJD 148:180–182, 2003; Hum Molec
Genet 11:833–840, 2002
Localized familial redundant scalp 
Clin Exp Dermatol
17:349–350, 1992
Localized lipomatous hypertrophy with microcephaly, mental
retardation, and deletion of short arm of chromosome 11 
AD
116:622, 1980; AD 115:978–979, 1979
Michelin tire baby syndrome – either nevus lipomatosis or
diffuse smooth muscle hamartoma; excessive folds of firm skin
on extremities, especially ankles and wrists; generalized
hypertrichosis, palmar cerebriform plaques
Ped Derm
22:245–249, 2005; Ped Derm 6:329–331, 1989; diffuse
lipomatous hypertrophy 
AD 100:320–323, 1969
Mucopolysaccharidoses (Hurler’s, Hurler–Schei, Sanfilippo,
Morquio, Maroteaux–Lamy, Sly syndromes) 
Rook p.2624–2625,
1998, Sixth Edition
Neurofibromatosis – rugose and plexiform neurofibromas 
JAAD
52:191–195, 2005
Noonan’s syndrome – cutis verticis gyrata 
Ped Derm
22:142–146, 2005
Pachydermoperiostosis (Touraine–Solente–Gole syndrome)
Syndromes of the Head and Neck, p.281–285, 1990
Patterson–David syndrome – redundant skin, hypertrichosis
Birth Defects 5:117–121, 1969
Patau’s syndrome (trisomy 13) – loose skin of posterior neck,
parieto-occipital scalp defects, abnormal helices, low-set ears,
simian crease of hand, hyperconvex narrow nails, polydactyly
Ped Derm 22:270–275, 2005; Rook p.3016, 1998, Sixth Edition
Proteus syndrome
Pseudoxanthoma elasticum – linear and reticulated
cobblestoned yellow papules and plaques 
AD 124:1559, 1988;
JAAD 42:324–328, 2000; Dermatology 199:3–7, 1999 ; PXE
and acrosclerosis 
Proc Roy Soc Med 70:567–570, 1977;
penicillamine-induced pseudoxanthoma elasticum 
JAAD
30:103–107, 1994; Dermatology 184:12–18, 1992; saltpetre-
induced pseudoxanthoma elasticum 
Acta DV 58:323–327, 1978
Shulman’s syndrome – rippled skin
Soto’s syndrome
Turner’s syndrome – neonatal cutis verticis gyrata 
Ped Derm
15:18–22, 1998
Williams syndrome – premature laxity of skin, congenital heart
disease (supravalvular aortic stenosis), baggy eyes, full cheeks,
prominent lips, dental malocclusion, delayed motor skills,
cocktail party personality 
J Pediatr 113:318–326, 1988