PSYCHOCUTANEOUS DISEASES
Bulimia nervosa – Russell’s sign (crusted knuckle nodules)
Clin Orthop 343:107–109, 1997; JAAD 12:725–726, 1985;
perniosis
Clin Sci 61:559–567, 1981; pseudo knuckle
pads (calluses on 2nd 5th MCP joints)
Psychol Med
9;429–48, 1979
Pachydermodactyly due to obsessive compulsive behavior
JAAD 38:359–362, 1998; AD 130:387, 1994
SYNDROMES
Bart–Pumphrey syndrome – knuckle pads, leukonychia,
sensorineural deafness, and diffuse palmoplantar
hyperkeratosis; autosomal dominant
JAAD 53:S225–230, 2005;
JAAD 51:292, 2004; Curr Prob Derm 14:71–116, 2002; NEJM
276:202–207, 1967
Dyskeratosis congenita
Ehlers–Danlos syndrome (molluscum pseudotumor) – knuckle
pads
Familial histiocytic dermatoarthritis – knuckle pads
Farber’s disease (disseminated lipogranulomatosis) – red
papules and nodules of joints and tendons of hands and feet;
deforming arthritis; papules, plaques, and nodules of ears,
back of scalp and trunk
Rook p.2642, 1998, Sixth Edition;
Am J Dis Child 84:449–500, 1952
Fibroblastic rheumatism – symmetrical polyarthritis,
nodules over joints and on palms, elbows, knees, ears, neck,
Raynaud’s phenomenon, sclerodactyly; skin lesions resolve
spontaneously
AD 139:657–662, 2003; Ped Derm 19:532–535,
2002; AD 131:710–712, 1995; Clin Exp Dermatol 19:268–270,
1994; JAAD 14:1086–1088, 1986; Rev Rheum
Ed Fr 47:345–351, 1980
François syndrome (dermochondrocorneal dystrophy) – knuckle
pads; nodules on hands, nose, and ears
Ann DV 104:475–478,
1977; AD 124:424–428, 1988
Greither’s palmoplantar keratoderma – knuckle pads,
hyperkeratosis of elbows, knees, shins
JAAD 53:S225–230,
2005
Hunter syndrome – MPS II
Ped Derm 12:370–372, 1995
Infantile digital fibromatosis
Infantile systemic hyalinosis – autosomal recessive; synophrys,
thickened skin, perianal nodules, dusky red plaques of buttocks,
gingival hypertrophy, joint contractures, juxta-articular nodules
(knuckle pads), osteopenia, growth failure, diarrhea, frequent
infections, facial red papules
JAAD 50:S61–64, 2004; Ped Derm
11:52–60, 1994
Juvenile hyaline fibromatosis – pearly white papules of face and
neck; larger papules and nodules around nose, behind ears,
on fingertips, knuckle pads; multiple subcutaneous nodules of
scalp, trunk, and extremities, papillomatous perianal papules;
joint contractures, skeletal lesions, gingival hyperplasia, stunted
growth
Textbook of Neonatal Dermatology, p.444–445, 2001;
Caputo p.54, 2000; AD 121:1062–1063, 1985;
AD 107:574–579, 1973
Keratosis-ichthyosis-deafness (KID) syndrome – partial
leukonychia, deafness
JAAD 53:S225–230, 2005
Knuckle pads, leukonychia, and deafness syndrome
Ghatan p.159, 2002, Second Edition
Knuckle pads with palmoplantar keratoderma and
acrokeratoelastoidosis
Ledderhose’s nodules (plantar fibromatosis)
JAAD 41:106–108,
1999; Dupuytren’s contracture (palmar fibromatosis) and/or
Peyronie’s disease – knuckle pads
Lipoid proteinosis – acral papules
BJD 151:413–423, 2004;
JID 120:345–350, 2003; BJD 148:180–182, 2003; Hum Molec
Genet 11:833–840, 2002
Mal de Meleda (recessive transgressive palmoplantar
keratoderma) – knuckle pads
Curr Prob Derm 14:71–116, 2002;
Ped Derm 14:186–191, 1997
Multicentric reticulohistiocytosis – digital papule; knuckle pads
yellow papules and plaques
AD 140:919–921, 2004; Rook
p.2325–2326, 1998, Sixth Edition; AD 126:251–252, 1990;
Oral Surg Oral Med Oral Pathol 65:721–725, 1988; Pathology
17:601–608, 1985; JAAD 11:713–723, 1984; AD 97:543–547,
1968
Neurofibromatosis
Pachydermoperiostosis – knuckle pads
J Dermatol 27:106–109,
2000
Polyfibromatosis syndrome – Dupuytren’s contracture, knuckle
pads, Peyronie’s disease, keloids, or plantar fibromatosis
Rook p.2044, 1998, Sixth Edition; stimulation by phenytoin
BJD 100:335–341, 1979
Reflex sympathetic dystrophy with chilblain-like lesions – digital
papule
Rowell’s syndrome – lupus erythematosus and erythema
multiforme-like syndrome – perniotic lesions
JAAD 21:374–377,
1989
Stiff skin syndrome – knuckle pads
Ped Derm 3:48–53, 1985
Vohwinkel’s syndrome – knuckle papules, palmoplantar
keratoderma, ichthyosis, pseudoainhum
JAAD 44:376–378, 2001
TRAUMA
Barber’s hair sinus
Callosities, occupational (carpenters, live chicken hangers
Contact Derm 17:13–16, 1987 ), frictional, bulemic
Chilblains (perniosis) – tender, pruritic red or purple digital
papules
JAAD 45:924–929, 2001; Rook p.960–961, 1998,
Sixth Edition
Garrod’s pads – violinist’s knuckles (2nd and 3rd knuckles) –
thickened skin over the interphalangeal joints from intense
flexion of tendons of fingers
Cutis 62:261–262, 1998
Scars – mimic knuckle pads
Skier’s thumb
Acta Orthop Belg 65:440–446, 1999
Surfer’s nodules of anterior tibial prominence, dorsum of feet,
knuckles
Cutis 50:131–135, 1992
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