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URTICARIA AND URTICARIA-LIKE LESIONS



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[Encyclopedia of Differential Diagnosis in Dermatology] Paul Schneiderman, Marc E. Grossman - A Clinician\'s Guide to Dermatologic Differential Diagnosis, Volume 1 The Text (Encyclopedia of Differential Diagnosis in D

URTICARIA AND URTICARIA-LIKE LESIONS
677
Schneiderman page 600-722.qxd 5/16/2006 6:51 PM Page 677


PSYCHOCUTANEOUS DISORDERS
Factitial dermatitis – fixed urticaria 
Rook p.2800–2802, 1998,
Sixth Edition; JAAD 1:391–407, 1979
Psychological factors – stress 
Cutis 43:340, 1989
SYNDROMES
AHA syndrome (arthritis or arthralgia, hives, angioedema)
Rheumatol Int 7:277–279, 1987
Chediak–Higashi syndrome 
Rook p.2742, 1998, Sixth Edition
CINCA syndrome (chronic infantile neurologic cutaneous
articular syndrome) – urticarial-like lesions 
Ped Derm
22:222–226, 2005; Eur J Pediatr 156:624–626, 1997 ; chronic
urticaria 
AD 136:431–433, 2000; J Pediatr 99:79–83, 1981
Familial cold autoinflammatory syndrome (cold urticaria)
BJD 150:1029–1031, 2004
Familial cold urticaria – autosomal dominant
Systemic atypical
Cold-dependent dermatographism
Cold erythema
Cold-induced cholinergic urticaria 
J Allergy Clin Immunol
68:438–441, 1981
Delayed cold urticaria
Localized cold-reflex urticaria 
J Allergy Clin Immunol
85:52–54, 1990
Leukocytoclastic vasculitis
Infections – mononucleosis, syphilis
Cold agglutinins
Cold hemolysins
Cold fibrinogens
Cryoglobulins
Familial Mediterranean fever – autosomal recessive; urticaria-
like lesions 
AD 134:929–931, 1998
Gleich’s syndrome (episodic angioedema with eosinophilia) –
angioedema, urticaria, fever, periodic weight gain, eosinophilia,
increased IgM 
AD 141:633–638, 2005; JAAD 20:21–27, 1989;
NEJM 310:1621–1626, 1984
Hereditary angioneurotic edema – transitory prodromal
nonpruritic urticarial eruption 
JAAD 53:373–388, 2005
Hypereosinophilic syndrome, idiopathic 
BJD 144:639, 2001;
AD 132:583–585, 1996; Blood 83:2759–2779, 1994;
AD 114:531–535, 1978; urticaria and/or angioedema Med Clin
(Barc) 106:304–306, 1996; AD 132:535–541, 1996; Sem
Derm 14:122–128, 1995
Hyper-IgD syndrome – periodic fever, red macules or
papules, urticaria, annular erythema, red nodules, arthralgias,
abdominal pain, lymphadenopathy; combinations of
fever, arthritis and rash, annular erythema and pustules
AD 136:1487–1494, 2000; Ann DV 123:314–321, 1996;
AD 130:59–65, 1994
Hyper-IgE syndrome (Job’s syndrome) (Buckley’s syndrome) –
contact urticaria; dermatitis of scalp, axillae, and groin; recurrent
bacterial infections of skin with cold abscesses, infections of
nasal sinuses and respiratory tract 
Curr Prob Derm 10:41–92,
1998; Medicine 62:195–208, 1983
IPEX syndrome – X-linked; immune dysregulation,
polyendocrinopathy, enteropathy; mutation of FOXP3; nummular
dermatitis, urticaria, scaly psoriasiform plaques of trunk
and extrexities, penile rash, alopecia universalis, bullae
AD 140:466–472, 2004
Kawasaki’s disease – macular, morbilliform, urticarial,
scarlatiniform, erythema multiforme-like, pustular, erythema
marginatum-like exanthems 
JAAD 39:383–398, 1998
Muckle–Wells syndrome – autosomal dominant; macular
erythema, urticaria (cold air urticaria), deafness, extremity pain,
nephropathy, amyloidosis 
BJD 151:99–104, 2004; JAAD
39:290–291, 1998
NOMID – neonatal onset multisystem inflammatory disease –
generalized evanescent urticarial macules and papules 
Ped
Derm 22:222–226, 2005; Textbook of Neonatal Dermatology,
p.302, 2001
Periodic diseases with cyclic edema/periodic edema – may
include hereditary angioedema, familial Mediterranean fever,
capillary leak syndrome and autoimmune progesterone urticaria
Int J Dermatol 18:824–827, 1979
Relapsing polychondritis 
Clin Exp Rheumatol 20:89–91, 2002
Schnitzler’s syndrome – chronic urticaria, intermittent
fever, and IgM monoclonal gammopathy (macroglobulinemia),
high ESR, leukocytosis, arthralgia, arthritis, with bone pain
(osteosclerotic), palpable lymphadenopathy,
hepatosplenomegaly 
BJD 142:954–959, 2000; JAAD
30:316–318, 1994; AD 130:1193–1198, 1994; JAAD
20:855–857, 1989; JAAD 20:206–211, 1989
Sweet’s syndrome
Systemic capillary leak syndrome (Clarkson syndrome)
Bolognia p.296, 2004
Tumor necrosis factor (TNF) receptor 1-associated periodic
fever syndromes (TRAPS) (same as familial Hibernian fever,
autosomal dominant periodic fever with amyloidosis, and benign
autosomal dominant familial periodic fever) – erythematous
patches, tender red plaques, fever, annular, serpiginous,
polycyclic, reticulated, and migratory patches and plaques
(migrating from proximal to distal), urticaria-like lesions, lesions
resolving with ecchymoses, conjunctivitis, periorbital edema,
myalgia, arthralgia, abdominal pain, headache; Irish and
Scottish predominance; mutation in TNFRSF1A – gene
encoding 55 kDa TNF receptor 
Medicine 81:349–368, 2002;
Netherlands Journal of Medicine 59:118–125, 2001;
AD 136:1487–1494, 2000
Wells’ syndrome (eosinophilic cellulitis) – red plaques
resembling urticaria or cellulitis 
JAAD 18:105–114, 1988
TOXINS
Eosinophilia myalgia syndrome (
L
-tryptophan related) –
morphea, urticaria, papular lesions; arthralgia 
BJD
127:138–146, 1992; Int J Dermatol 31:223–228, 1992; Mayo
Clin Proc 66:457–463, 1991; Ann Intern Med 112:758–762,
1990
Mustard gas exposure 
AD 128:775–780, 1992; JAAD
32:765–766, 1995, JAAD 39:187–190, 1998
Scombroid fish poisoning – urticaria-like lesions
Br Med J
281:71–72, 1980
Toxic oil syndrome 
JAAD 18:313–324, 1988
TRAUMA
Acquired cold-contact urticaria – painful erythema 
JAMA
180:639–642, 1962
Chemical burn – inducing bullous pemphigoid 
JAAD
38:337–340, 1998
Cold urticaria 
J Allergy Clin Immunol 85:965–981, 1990;
Semin Dermatol 6:292–301, 1987; familial (autosomal
dominant) 
AD 129:343–346, 1993; immediate cold-contact
urticaria 
JAAD 13:636–644, 1985; delayed cold-contact
urticaria 
Proc R Soc Med 58:622–623, 1965; localized cold
contact urticaria 
J Allergy Clin Immunol 86:272–273, 1990;

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