Сборник содержит материалы научной мультиконференции «Биотех- нология медицине будущего»

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www.bIoSSEt.CoM

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ШКОЛА-КОНФЕРЕНЦИЯ 
«ТЕРАПЕВТИЧЕСКИЕ НУКЛЕИНОВЫЕ КИСЛОТЫ» 
С УЧАСТИЕМ МОЛОДЫХ УЧЕНЫХ

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Всероссийская мультиконференция с международным участием «Биотехнология – медицине будущего»
29 июня - 2 июля 2019 г., г. Новосибирск, Россия
22
From chemical biology to medicine: functional bioconjugates
of nucleic acids and peptides for future therapeutic applications
Bichenkova E.V.
1
, Amirloo B.
1
, Yousaf S.
1
, Zenkova M.A.
2
, Clarke D.J.
1
, Patutina O.A.
2
, 
Staroseletz Y.Y.
2
, Miroshnichenko S.K.
2
1
The University of Manchester, Manchester, United Kingdom 
2
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
A major biomedical and pharmaceutical challenge is to provide quick, safe and effective 
treatment of various types of human pathophysiology. However, the lack of rapid, reliable 
and robust techniques for detection of disease biomarkers in biological samples represents 
the major bottleneck in screening of different pathological conditions in humans. The major 
disadvantages of the available diagnostic assays include the high production costs, inaccuracy, 
poor sensitivity and lack of reproducibility, which hamper the transition of biomedical 
diagnostics from specialised laboratories to clinical settings. Therefore, there is an urgent need 
for the development of novel advanced technologies allowing 
in situ
nucleic acid detection for 
diagnostic purposes to improve health outcomes through early-stage diagnosis, more precise 
monitoring of therapeutic treatments and disease prognosis. 
With regards to therapeutic treatments, traditional targeting of 
downstream
pathways 
to treat the physiological abnormalities of disease states at the level of expressed proteins 
is proving increasingly difficult and often suffers from off-target effects and severe toxicity.
A promising alternative to small molecular drugs is based on the RNA-targeting approaches, 
which offer the advantages of absolute selectivity, improved potency and reduced toxicity.
This talk is focused on the development of new strategies for development of novel 
molecular diagnostics and therapeutics based on the functional bioconjugates of nucleic acids 
and peptides.
Our research focus involves the design and fabrication of novel functional biomaterials 
with controlled chemical and biological properties, which can be used as a basis for devel-
opment of clinically- and commercially-useful diagnostics, reagents and therapeutics in order 
to provide solutions to complex biological and biomedical grand challenges, unmet by conven-
tional approaches. To achieve this, we work at the interface between synthetic, analytical, 
physical and computational chemistry with structural and chemical biology and use biologi-
cally-friendly building blocks (
e.g.
nucleic acids and peptides), which are bio-degradable and 
highly controllable in terms of their structure, properties and function. These recent advances 
open up new exciting avenues for development of a novel technological platform for rapid 
detection and effective treatment of human pathophysiology. 
This work was supported by the grant of Russian Science Foundation 19-74-30011.

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Всероссийская мультиконференция с международным участием «Биотехнология – медицине будущего»
29 июня - 2 июля 2019 г., г. Новосибирск, Россия
23