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CIE AS Biology (9700) 2019-2021 Revision Notes

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2. Biological Molecules

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Page 55

The interactions that occur between the R groups of amino acids determines the shape

and function of a protein. These interactions are found within tertiary structures of

proteins

Disulphide

Disulphide bonds are strong covalent bonds that form between two cysteine R groups

(as this is the only amino acid with a sulphur atom)

These bonds are the strongest within a protein, but occur less frequently, and help stabilise

the proteins

These are also known as disulphide bridges

Can be broken by oxidation

Disulphide bonds are common in proteins secreted from cells eg. insulin

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