Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Document Outline

• Introduction 
• Methods for Production of Polymeric Nanoparticles 
  • Solvent Evaporation 
  • Emulsification/Solvent Diffusion 
  • Emulsification/Reverse Salting-Out 
  • Nanoprecipitation 
• Characterization of Polymeric Nanoparticles 
  • Morphology 
  • Particle Size Distribution 
  • Chemical Composition and Crystal Structure 
  • Molar Mass Distribution of the Polymer 
  • Surface Area and Chemistry 
  • Zeta Potential 
  • pH of Suspensions 
  • Stability of Polymeric NPs Suspensions 
  • Determination of the Drug Association 
  • Pharmaceutical In Vitro Release Kinetics 
• From Ecotoxicology to Nanoecotoxicology 
  • Challenges in Nanoecotoxicology Research 
  • Monitoring of Nanoparticles’ Toxicity 
• In Vitro and Vivo Toxicological Studies 
• Conclusions 
• References