Systematic Review of Gossypol/at-101 in Cancer Clinical Trials

Document Outline

• Introduction 
• Materials and Methods 
• Results 
  • Trials Determining Therapeutic Effect and Toxicity of Single-Agent Gossypol/AT-101 
  • Trials Evaluating Efficacy and Safety of Gossypol/AT-101 in Combination with Standard Chemo- and Radiation Therapies in Cancer Patients 
  • Investigations Not Published as an Original Manuscript/Work on PubMed, MEDLINE, and Cochrane Databases but Containing Results of Clinical Investigations 
• Summary 
  • Bioavailability, Digestion, Transporters, and Liver Toxicity 
  • Potential Benefit and Current Limitations 
  • Dose-Limiting Toxicities 
  • Association of Gossypol/AT-101 with Cancer Parameters 
  • Future Perspectives 
• Conclusions 
• References