Corticosteroids – injected; topical fluorinated
Rook p.3249,
1998, Sixth Edition
Etretinate – lightening of hair
JAAD 34:860, 1996
Hydroxychloroquine
Ghatan p.248, 2002,
Second Edition
Mephenesin – lightening of hair
Br Med J i:997–998, 1963
Pityriasis rosea-like drug eruption
Retinoids
Ghatan p.248, 2002, Second Edition
Toxic epidermal necrolysis – depigmentation after toxic
epidermal necrolysis
JAAD 10:106–109, 1984
EXOGENOUS AGENTS
Betel leaves – mottled hyperpigmentation evolving into
confetti-like hypopigmentation
JAAD 40:583–589, 1999
Chemical leukoderma
Rook p.1807, 1998, Sixth Edition
Hydroquinone
Rook p.3249, 1998, Sixth Edition
Monobenzyl ether of hydroquinone
Monoethyl ether of hydroquinone
Monomethyl ether of hydroquinone
p-isopropylcatechol
p-methylcatechol
p-tert-butylcatechol
p-
tert-butylphenol
p-
tert-amylphenol
Mercaptoamines
N,N
′
N
′′
-triethylenethiophosphoramide (thiotepa)
Condoms – chemical hypopigmentation
Rook p.2295, 1998,
Sixth Edition
Facial dressings of betel pepper (piper beetle)
JAAD 40:583–589, 1999
Irritant contact dermatitis to toothpaste
Mercaptoethylamines
Ghatan p.248, 2002, Second Edition
INFECTIONS AND INFESTATIONS
AIDS –
premature canities
Tyring p.367, 2002
Herpes zoster
Rook p.3249, 1998, Sixth Edition
Leishmaniasis – post-kala-azar dermal leishmaniasis
BJD 143:136–143, 2000; JAAD 34:257, 1996
Leprosy – indeterminate – hypopigmented macules of face,
arms, buttocks, or trunk
Clin Inf Dis 32:930–937, 2001;
Rook p.1222, 1998,
Sixth Edition; tuberculoid
or borderline
tuberculoid – hypopigmented macule with dry, hairless
anesthetic surface with fine wrinkling
Int J Lepr Other Mycobact
Dis 67:388–391, 1999; lepromatous leprosy Rook p.1224, 1998,
Sixth Edition; borderline lepromatous Rook p.1227, 1998,
Sixth Edition; dermatomal hypopigmented macular lesions
Experientia 39:723–725, 1983
Millipede secretions – red eyes and mahogany pigmentation
with bullae; heal with hypopigmentation
Rook p.1474, 1998,
Sixth Edition
Onchocerciasis – hypopigmented atrophic patches
JAAD 45:435–437, 2001; Cutis 65:293–297, 2000;
depigmentation and atrophy
AD 140:1161–1166, 2004;
Rook p.3249, 1998, Sixth Edition; AD 120:505–507, 1984
Pediculosis – Vagabond’s leukoderma
Ghatan p.248, 2002,
Second Edition
Pinta – generalized cutaneous phase – hypochromic papules
and patches
Rook p.1274, 1998, Sixth Edition; late secondary
phase hypopigmented, depigmented hyperpigmented atrophic
skin
Rook p.1274, 1998, Sixth Edition; tertiary Cutis
51:425–430, 1993
Schistosomiasis – ectopic cutaneous granuloma – skin-colored
papule, 2–3 mm; group to form mamillated plaques; facial
hypopigmented plaque
Dermatol Clin 7:291–300, 1989;
BJD 114:597–602, 1986
Streptocerciasis –
Mansonella streptocerca – hypopigmented
macules
Derm Clinics 17:151–185, 1999
Syphilis –
secondary; as macular syphilid fades get
depigmented macules with hyperpigmented background
(leukoderma syphiliticum) on back and sides of neck (necklace
of Venus)
Rook p.1248–1249, 1998, Sixth Edition
Tinea corporis
Tinea imbricata-
Trichophyton concentricum – hypopigmented
plaques
Clin Exp Dermatol 13:232–233, 1988; Trans R Soc Trop
Med Hyg 78:246–251, 1984
Tinea versicolor
Textbook
of Neonatal Dermatology, p.227,
2001; Semin Dermatol 4:173–184, 1985
Verrucae plana (flat warts)
Tyring p.261, 2002
Yaws – secondary – lenticular hypopigmented macules
Rook p.1270, 1998, Sixth Edition
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