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HYPERPIGMENTATION, PATCHY



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[Encyclopedia of Differential Diagnosis in Dermatology] Paul Schneiderman, Marc E. Grossman - A Clinician\'s Guide to Dermatologic Differential Diagnosis, Volume 1 The Text (Encyclopedia of Differential Diagnosis in D

HYPERPIGMENTATION, PATCHY
261
Schneiderman page 200-300.qxd 5/16/2006 6:49 PM Page 261


Pagetoid dyskeratosis 
JAAD 50:483–484, 2004
Plexiform neurofibroma – patchy hyperpigmentation of overlying
skin 
Textbook of Neonatal Dermatology, p.402, 2001
Seborrheic keratosis
Smooth muscle hamartoma 
JAAD 46:477–490, 2002
Vulvar lentigines 
Genital Skin Disorders, Fischer and
Margesson, CV Mosby p.187, 1998
Waldenström’s macroglobulinemia – red–brown or violaceous
macules – neoplastic B-cell infiltrates 
AD 120:778–781, 1984
PHOTODERMATOSES
Actinic lichen planus – hyperpigmented patches of the face
AD 135:1543–1548, 1999; tropical lichen planus (lichenoid
melanodermatitis) 
BJD 101:651–658, 1979; mimicking melasma
JAAD 18:275–278, 1988
Berloque dermatitis 
AD 90:572–576, 1964
Ephelides (freckles) – autosomal dominant 
Rook p.1771, 1998,
Sixth Edition
Melasma – upper lip, cheeks, forehead, chin 
Rook p.3383,
1998, Sixth Edition; JAAD 15:894–899, 1986; JAAD 4:698–710,
1981
Phototherapy of neonatal jaundice – darkening of treated areas
J Pediatr 82:1042–1043, 1973
Phytophotodermatitis, including lime phototoxicity 
Rook p.1787,
1998, Sixth Edition
Poikiloderma of Civatte 
Ann Dermatol Syphilol 9:381–420, 1938
Sunburns
PRIMARY CUTANEOUS DISEASES
Acanthosis nigricans 
Am J Public Health 84:1839–1842, 1994
Acquired dermal melanocytosis – blue–black 
JAAD
45:609–613, 2001
Acrogeria – mottled hyperpigmentation of acral skin
BJD 142:178–180, 2000
Acromelanosis – black patients 
JAAD 2:128–131, 1980;
Cutis 5:1119–1120, 1969
Acromelanosis progressiva 
AD 86:412–418, 1962
Atrophoderma of Moulin – acquired atrophic pigmented band-
like lesions following Blaschko’s lines 
JAAD 49:492–498, 2003;
Ann DV 119:729–736, 1992
Atrophoderma of Pasini and Pierini 
Dermatol 190:203–206,
1995; JAAD 30:441–446, 1994; Int J Derm 10:643–645, 1984
Axillary apocrine chromhidrosis 
AD 124:494–496, 1988
Chromhidrosis – black, violet, blue, brown, yellow, green, rarely
red 
Rook p.2001, 1998, Sixth Edition
Confluent and reticulated papillomatosis
Cutis tricolor – hyper- and hypopigmented lesions with a
background of normal skin 
Eur J Pediatr 159:745–749, 2000
Dentinogenesis imperfecta – brown stained hypoplastic teeth
Rook p.3051, 1998, Sixth Edition
Dowling–Degos disease (reticulated pigmentary anomaly of the
flexures) 
AD 114:1150–1157, 1978
Dyschromatosis universalis
Epidermolysis bullosa simplex herpetiformis (Dowling–Meara)
with mottled pigmentation 
Ped Derm 13:306–309, 1996
Epidermolysis bullosa simplex with mottled pigmentation of
neck, upper trunk, arms and leg with or without keratoderma
(punctate palmoplantar keratoses); cutaneous atrophy, nail
dystrophy 
BJD 150:609–611, 2004; JAAD 15:1289–1291, 1986;
Clin Genet 15:228–238, 1979
Erythema annulare centrifugum – hyperpigmentation, rarely
Rook p.2088, 1998, Sixth Edition; Bull Soc Fr Dermatol Syphiligr
71:450–452, 1964
Erythema dyschromicum perstans (ashy dermatosis) –
blue–gray patches with red raised margins; coalesce over face,
trunk, and extremities; hypo- and hypermelanotic macules
resembling late pinta 
Cutis 68:25–28, 2001; AD
124:1258–1260, 1988; Int J Derm 24:630–633, 1985
Erythema elevatum diutinum – healed 
Rook p.2194, 1998, Sixth
Edition; giant annuli BJD 143:415–420, 2000
Erythromelanosis follicularis of face and neck – red–brown
pigmentation with telangiectasias, follicular papules
JAAD 32:863–866, 1995
Erythrose peribuccale pigmentaire of Brocq – diffuse brown
pigmentation around mouth with narrow perioral sparing; central
face, forehead, angles of jaw, temples 
Rook p.1791, 1998,
Sixth Edition
Facial hyperpigmentation in Africans – bleaching creams,
mercury, photosensitizing herbs, fixed drug eruptions, melasma
Int J Derm 30:186–191, 1991
Familial progressive hyperpigmentation
Follicularis faciei et colli
Hematohidrosis 
Rook p.2001, 1998, Sixth Edition
Human chimera with pigment anomalies 
BJD 103:489–498, 1980
Hyperpigmented macules of palms and soles in blacks
Int J Dermatol 18:222–225, 1979
Lichen planus 
Rook p.1904–1912, 1998, Sixth Edition; lichen
planus pigmentosus 
JAAD 21:815, 1989; Dermatologica
149:43–50, 1974; lichen planus tropicus
Lichen simplex chronicus – in blacks 
Rook p.3247, 1998,
Sixth Edition; vulvar lichen simplex chronicus
JAAD 23:982–984, 1990
Linear and whorled nevoid hypermelanosis
JAAD 19:1037–1044, 1988; Ped Derm 10:156–158, 1993
vs. Chimerism
Conradi–Hünermann syndrome (streaked
hyperpigmentation and hyperkeratosis) 
JAAD 21:248–256,
1989
Dyschromatosis universalis
Early epidermal nevus
Familial progressive hyperpigmentation
Hypomelanosis of Ito
Incontinentia pigmenti
Lichen sclerosus et atrophicus
Notalgia paresthetica 
JAAD 18:25–30, 1988; Cutis 23:471–473,
1973
Occupational melanosis
Periorbital hyperpigmentation 
Rook p.2984–2985, 1998, Sixth
Edition; AD 100:169–174, 1969
Familial
Lichen planus
Mercurial preparations – blue or gray–brown
Post-traumatic
Psoralens in cosmetics
Silver preparations – blue or gray–brown
Pigmentary lines of demarcation
Type A – Futcher’s lines, Voigt’s lines – dorsoventral line on
the upper anterior aspects of the arms
Type B – posteromedial aspect of legs
Type C – pair of vertical hypopigmented lines over the
presternal region
Type D – posteromedian line, hyperpigmented over midback
in Asians
Type E – periareolar hypopigmentation in black children

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