INFLAMMATORY DISORDERS
Connective tissue panniculitis – nodules, atrophic linear plaques
of face, upper trunk, or extremities
AD 116:291–294, 1980
Eosinophilic fasciitis (Shulman’s syndrome)
Curr Rheum Reports
4:113, 2002; Rheum Dis Clin North Am 21:231, 1995; Assoc Am
Physicians 88:70, 1985; JAAD 1:221–226, 1979; Ann Rheum Dis
36:354–359, 1977; J Rheumatol 1 (Suppl 1):46, 1974
Sarcoid – morphea-like lesions
JAAD 44:725–743, 2001; JAAD
39:345–348, 1998; Clin Exp Rheumatol 8:171–175, 1990;
mimicking lipodermatosclerosis
Cutis 75:322–324, 2005
Subacute nodular migratory panniculitis
AD 128:1643–1648,
1992
Subcutaneous fat necrosis of the newborn – red to bluish-red
firm nodules and/or plaques; buttocks, thighs, shoulders, back,
cheeks, and arms; associated with hypercalcemia
JAAD
16:435–439, 1987; Clin Pediatr 20:748–750, 1981
METABOLIC DISORDERS
Acromegaly
Ghatan p.33, 2002, Second Edition
Bisalbuminemia – cold, blue hands; inability to extend fingers
BJD 95 (Suppl.14):54–55, 1977
Calcification – subcutaneous calcification (post-phlebitic
subcutaneous calcification) – chronic venous insufficiency;
non-healing ulcers; fibrosis
Radiology 74:279–281, 1960
Carcinoid syndrome – of legs
BJD 152:71–75, 2005; Arch Int
Med 131:550–553, 1973
Diabetes mellitus – diabetic hands (diabetic cheiroarthropathy)
(prayer sign) (waxy hands) – limited joint mobility
JAAD
49:109–111, 2003; Ped Derm 11:310–314, 1994; J Rheumatol
10:797–800, 1983; Arthritis Rheum 25:1357–1361, 1982;
diabetic thick skin
JAAD 16:546–553, 1987; with finger pebbling
JAAD 14:612–619, 1986; scleredema Dermatologica
146:193–198, 1973
Hashimoto’s thyroiditis
Hunter’s syndrome – decreased sulfoiduronate sulfatase –
sclerodermoid changes of the hands
Ped Derm 15:370–373, 1998
Hyaluronan metabolic abnormality – peau d’orange bound skin,
generalized lax and cerebriform redundant skin
J Pediatr
136:62–68, 2000
Hyperoxalosis – primary type I hyperoxalosis; glyoxylate
aminotransferase deficiency; sclerodermoid changes of legs
BJD 151:1104–1107, 2004
Hypopituitarism – post-partum; scleroderma-like
Rook p.2513,
1998, Sixth Edition
Hypothyroidism (myxedema) – edematous and indurated skin
Rook p.2513, 1998, Sixth Edition
Mucolipidosis type II
Mucopolysaccharidoses (Hunter’s and Hurler’s syndromes) –
acrosclerosis; Hurler – focal pebbly thickening of skin
Muscle glycogenosis – proximal extremities with contractures
Acta DV (Stockh) 52:379–385, 1972
Necrobiosis lipoidica diabeticorum
Int J Derm 33:605–617,
1994; JAAD 18:530–537, 1988
Nephrogenic fibrosing dermopathy (scleromyxedema-like
cutaneous fibrosing disorder) – associated with chronic renal
failure with or without hemodialysis
BJD 152:531–536,
2005; JAAD 48:55–60, 2003; JAAD 48:42–47, 2003; Am
J Med 114:563–572, 2003; AD 139:903–906, 2003; Am J
Dermatopathol 23:383–393, 2001; Lancet 356:1000–1001, 2000
Niemann–Pick disease
Paraproteinemia
Phenylketonuria – sclerodermoid changes of thighs and
buttocks in first year of life; contractures of legs; morphea-like
lesions in older children
JAAD 26:329–333, 1992; morphea
resulting in atrophoderma of Pasini and Pierini with
subcutaneous atrophy
JAAD 49:S190–192, 2003
Porphyria – porphyria cutanea tarda
BJD 129:455–457, 1993;
Dermatol Clinics 4:297–309, 1986; variegate porphyria –
pseudosclerodermatous changes of hands and fingers
Rook
p.2586–2587, 1998, Sixth Edition; hepatoerythropoietic
porphyria
JAAD 11:1103–1111, 1984; AD 116:307–313, 1980;
BJD 96:663–668, 1977; erythropoietic protoporphyria –
‘pseudoscleroderma’
Sybert’s Genetic Skin Disorders, p.536,
Oxford University Press, 1997; Gunther’s disease – congenital
erythropoietic porphyria – sclerosis of hands
Ped Derm
20:498–501, 2003; Clin Exp Dermatol 12:61–65, 1987
Scurvy – chronic
Nature 202:708–709, 1964
Spherocytosis – pseudoerysipelas due to recurrent hemolysis with
underlying sclerodermoid changes
JAAD 51:1019–1023, 2004
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