Bog'liq Kurzweil, Ray - Singularity Is Near, The (hardback ed) [v1.3]
Medicine. If you obtain an electrocardiogram (ECG) your doctor is likely to receive an automated diagnosis using
pattern recognition applied to ECG recordings. My own company (Kurzweil Technologies) is working with United
Therapeutics to develop a new generation of automated ECG analysis for long-term unobtrusive monitoring (via
sensors embedded in clothing and wireless communication using a cell phone) of the early warning signs of heart
disease.
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Other pattern-recognition systems are used to diagnose a variety of imaging data.
Every major drug developer is using AI programs to do pattern recognition and intelligent data mining in the
development of new drug therapies. For example SRI International is building flexible knowledge bases that encode
everything we know about a dozen disease agents, including tuberculosis and H. pylori (the bacteria that cause
ulcers).
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The goal is to apply intelligent datamining tools (software that can search for new relationships in data) to
find new ways to kill or disrupt the metabolisms of these pathogens.
Similar systems are being applied to performing the automatic discovery of new therapies for other diseases, as
well as understanding the function of genes and their roles in disease.
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For example Abbott Laboratories claims that
six human researchers in one of its new labs equipped with AI-based robotic and data-analysis systems are able to
match the results of two hundred scientists in its older drug-development labs.
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Men with elevated prostate-specific antigen (PSA) levels typically undergo surgical biopsy, but about 75 percent
of these men do not have prostate cancer. A new test, based on pattern recognition of proteins in the blood, would
reduce this false positive rate to about 29 percent.
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The test is based on an AI program designed by Correlogic
Systems in Bethesda, Maryland, and the accuracy is expected to improve further with continued development.
Pattern recognition applied to protein patterns has also been used in the detection of ovarian cancer. The best
contemporary test for ovarian cancer, called CA-125, employed in combination with ultrasound, misses almost all
early-stage tumors. "By the time it is now diagnosed, ovarian cancer is too often deadly," says Emanuel Petricoin III,
codirector of the Clinical Proteomics Program run by the FDA and the National Cancer Institute. Petricoin is the lead
developer of a new AI-based test looking for unique patterns of proteins found only in the presence of cancer. In an
evaluation involving hundreds of blood samples, the test was, according to Petricoin, "an astonishing 100% accurate in
detecting cancer, even at the earliest stages."
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About 10 percent of all Pap-smear slides in the United States are analyzed by a self-learning AI program called
FocalPoint, developed by TriPath Imaging. The developers started out by interviewing pathologists on the criteria they
use. The AI system then continued to learn by watching expert pathologists. Only the best human diagnosticians were
allowed to be observed by the program. "That's the advantage of an expert system," explains Bob Schmidt, Tri-Path's
technical product manager. "It allows you to replicate your very best people."
Ohio State University Health System has developed a computerized physician order-entry (CPOE) system based
on an expert system with extensive knowledge across multiple specialties.
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The system automatically checks every
order for possible allergies in the patient, drug interactions, duplications, drug restrictions, dosing guidelines, and
appropriateness given information about the patient from the hospital's laboratory and radiology departments.