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Combined active and passive prophylactic



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Combined active and passive prophylactic 
immunisation is planned to get both the 
immediate but temporary benefit of protection 
supplied by serum and the more remote but 
lasting benefit afforded by vaccine injection. It 
has been used mainly in diphtheria. If, for 
example, this disease breaks out in a school, a 


 
 
133 
small dose of serum, say 500 antitoxic units, may 
be injected at once into all the children and a first 
dose of diphtheria- prophylactic vaccine is 
administered four weeks later. The serum confers 
passive protection during the time when active 
immunity is developing. Since the main effect of 
the serum disappears in 3-4 weeks and active 
immunity is not established for 5-6 weeks, there 
may be a short intermediate period of relative 
susceptibility, but it has been found in practice 
that, as long as the children are protected from 
infection by temporary segregation of earners, 
there is very little risk of diphtheria breaking out 
again.
316- We can understand from the passage that the 
protection supplied by serum injection ------- .
A) should only be thought of in exceptional 
conditions 
B) is immediately effective but short-termed 
C) is unreliable and can have an adverse effect on 
the patient 
D) has generally proved unsuccessful except for 
during diphtheria epidemics 
E) lasts long and is entirely safe 
 
317- The text gives a detailed account of ------- .
A) how to determine who are vulnerable in an 
outbreak of diphtheria 
B) the special advantages of active prophylactic 
immunisation 
C) an immunisation scheme specially designed to 
deal with an outbreak of diphtheria in a school 
D) the stages through which diphtheria turns out an 
epidemic 
E) the various symptoms of diphtheria and the 
treatment called for at different stages of the disease 

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