Conference Paper

 
Фойдаланилган адабиётлар: 
1. Бобоев М. “Қанд лавлагидан шакар ишлаб чиқариш технологиясини 
такомиллаштириш ва мавзуга янги педагогик технологияларни қўллаш” БМИ. 
НамМПи. 2013 й. 
2. Холиқов.Б.М. Қанд лавлаги етиштириш агротехнологияси ва алмашлаб экиш. 
Тошкент; “Наврўз” нашриёти 2013 й (25-26 бетлар) 
MOLECULAR AND CRYSTAL STRUCTURE OF RACEMIC ETODOLAC
1
Alimnazarov B.X., 
2
Amanov B.Sh., 
2
Choriev O.E., 
3
Ashurov J.M., 
3
Khodjaniyazov Kh.U., 
3
Ibragimov B.T. 
1
Termez State University, Termez, Uzbekistan
 
2
Termez branch of Tashkent state technical university, Termez, Uzbekistan.
 
3
Institute of Bioorganic Chemistry of AS, Tashkent, Uzbekistan 
An important problem of modern science of Uzbekistan is an integration of science 
and production. In the field of chemical science, the creation of new pharmacologically active 
compounds is becoming important in order to provide the internal market with original 
domestic medicines. Improving the quality and purity of these drugs are of crucial interest. 
Moreover, obtaining of more exact geometric characteristics of already known substances is 
important for their practical use and structure-function relationships.
Research in the development of new compounds with biologically active molecules 
has attracted a great interest. Etodolac possesses analgesic and antipyretic activity and is used 
as non-steroidal anti-inflammatory drug. It is effective to treat rheumatoid arthritis, 
furthermore, gynecologic, urologic, and orthopedic diseases. It was reported that the anti-
inflammatory and prostaglandin synthetase inhibiting properties of etodolac reside almost 
exclusively in its (+)- enantiomer.
The geometry and absolute configuration of molecules of etodolac enantiomers have 
been determined earlier in work [1] by X-ray crystallography (R-factor 11.6%). Thus, 
racemate of etodolac is the mixture of two optical isomers (Fig. 1).

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Техник ва технологик фанлар со
ҳ
аларининг инновацион масалалари. ТДТУ ТФ 2020 
91 
N
O
H
C
2
H
5
C
2
H
5
CH
2
COOH
N
O
H
C
2
H
5
C
2
H
5
HOOCCH
2
S
R
Fig. 1.
Chemical structure of etodolac enantiomers. 
We 
have 
studied 
X-ray 
crystal 
structure 
of 
(+)-1,8-diethyl-1,3,4,9-
tetrahydropyrano[3,4-b]-indole-1-acetic acid (etodolac) with improved R-factor 5.86(%). 
There is a sufficiently strong intramolecular H-bond between pyran moiety oxygen atom and 
carboxylic group hydrogen atom O2-H

O1 and intermolecular hydrogen bond between 
hydrogen at pyrrole nitrogen and carbonyl oxygen atom of neighboring molecule N-H

O3 
(Fig. 2.) with lengths 1.860(2) and 2.050(3) Å, accordingly. These intermolecular H-bonds are 
associate molecules of etodolac into the 1-D chain.