Biokimyo pmd

MUNDARIJA

KIRISH .............................................................................................................

3

I BOB

OQSILLAR  VA  ULARNING  FUNKSIYASI

Oqsillarning elementar tarkibi .......................................................................... 8

Oqsillarning aminokislota tarkibi va aminokislotalarning tasnifi .................... 8

Oqsillarning fizik-kimyoviy xususiyatlari ..................................................... 12

Oqsillarning molekulyar massasi ................................................................... 12

Oqsil molekulalarining shakli va o‘lchami .................................................... 16

Oqsillarning fizik va kimyoviy xossalari ....................................................... 16

Oqsillarning tuzilishi ...................................................................................... 19

Oqsillarning birlamchi strukturasi .................................................................. 20

Oqsillarning ikkilamchi strukturasi ................................................................ 23

Oqsillarning uchlamchi strukturasi ................................................................ 26

Oqsillarning to‘rtlamchi strukturasi ............................................................... 27

Oqsillarning to‘rtlamchi strukturasining hosil bo‘lishi .................................. 28

Oqsillarning denaturatsiyasi. Qaytar va qaytmas denaturatsiya ..................... 29

Oqsillarni ajratib olish va tozalash ................................................................. 30

Oqsillarni fraksiyalash yo‘li bilan ajratish ..................................................... 31

Oqsillarni tuzlar ta‘sirida cho‘ktirib ajratish .................................................. 31

Dializ usuli ..................................................................................................... 32

Elektroforez usuli ........................................................................................... 33

Oqsil strukturasini o‘rganish usullari ............................................................. 34

Oqsillarning tasnifi va nomenklaturasi .......................................................... 34

Oqsillarning biologik xossasini birlamchi strukturaga bog‘liqligi ................ 36

Oqsillarning  birlamchi strukturasining turga oid spetsifikligi ...................... 37

Oqsillarning biologik xossasining konformatsiyasiga

 (ikkilamchi  va uchlamchi strukturaga) bog‘liqligi ....................................... 38

Oqsil molekulasining funksiya bajarishiga bog‘liq

bo‘lgan konformatsion o‘zgarish ................................................................... 39

Oqsillarning strukturasi va ko‘p molekulali . Oqsillar strukturasining

 o‘zaro yig‘ilishi ............................................................................................. 39

Turli a’zo oqsillarining funksiyasiga qarab har hil bo‘lishi, ontogenez va

kasalliklarda a’zolar oqsil tarkibining o‘zgarishi ........................................... 40

Biologik faol peptidlar ................................................................................... 42

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464

Izofunksional oqsillar ..................................................................................... 43

Oqsillarning ligandlar bilan o‘zaro ta’siri ...................................................... 44