Murdoch Children’s Research Institute Animal Ethics Committee Test for new researchers



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MCRI AEC Test Version 1 – New starters


Murdoch Children’s Research Institute Animal Ethics Committee

Test for new researchers
This test is designed to access knowledge and comprehension of the NHMRC Australian Code of Practice for the Care and Use of Animals for Scientific Purposes (8th edition 2013
It is an open book test that is made up of multiple-choice questions.

All questions must be answered, and a mark of 80% is required to pass. Each question has only one correct answer.


If a pass mark is not received, the employee must re-sit the test until a pass mark is received.
Employees will not be approved by the AEC to work with animals until they have passed this test.
Code of practice can be downloaded: http://www.nhmrc.gov.au/guidelines/publications/ea28


Questions



  1. Which of the following statements is TRUE in relation to compliance to the code?

  1. The code applies throughout the animals involvement in activities and projects, including acquisition, transport, breeding, housing, husbandry, the use of animal in a project, and the provisions for the animal at the completion of their use

  2. The code does not apply to the animals remaining alive at the completion of a project

  3. The code only applies to the animals involvement in activities and projects that are undertaken within the MCRI grounds.

  4. The code does not apply to the director of the Institute




  1. Which of the following is NOT one of the 3 R’s?

  1. Research

  2. Reduction

  3. Refinement

  4. Replacement




  1. An Animal Ethics Committee is made up of a Chairperson, and Members including, at least one person from each of the 4 Categories (A – D).

Of the following, who IS considered to be a member of Category D?

  1. MCRI Employee that has never been involved in the use of animals in scientific or teaching activities

  2. Independent member of the community that has never been involved in the use of animals in scientific or teaching activities

  3. Veterinarian

  4. Retired Animal Facility Manager

  1. According to the code, which of the following statements best describes the primary responsibility of an AEC?

  1. The primary responsibility of an AEC is to ensure that an approved project or activity is completed and results published.

  2. The primary responsibility of an AEC is to advise an Institution on how to breed animals for scientific purposes

  3. The primary responsibility of an AEC is to ensure, on behalf of the institution for which it acts, that all activities relating to the care and use of animals are conducted incompliance with the Australian Code for the care and use of animals for Scientific Purposes.

  4. The primary responsibility of an AEC is to ensure investigators are not injured whilst undertaking a project or activity.




  1. Which of the following statements is TRUE in relation to the Codes definition of the ability of a fetus to feel pain?

  1. Fetuses do not feel pain, and therefore it is not necessary to consider methods to manage pain and distress.

  2. Unless proved otherwise, it must be assumed that fetuses have comparable requirements for anaesthesia and analgesia as adult animals of the same species, and therefore methods to manage pain and distress must be designed accordingly.

  3. Pain and distress cannot be managed in fetuses, therefore they may not be used for experimental purposes.

  4. All of the above




  1. According to the Code, which of the following should be considered to be used as part of a plan to manage pain and distress in animals?

  1. Local and General anaesthetics

  2. Sedatives

  3. Analgesics

  4. All of the above




  1. Which of the following is NOT detailed in the Code regarding pain and distress in animals used for scientific purposes?

  1. It is only the responsibility of the investigator to actively monitor and access their animals for signs of pain and distress.

  2. An animal must be monitored and assessed for signs of pain and distress by a competent person throughout the it’s life

  3. Procedures, husbandry and care must be performed by competent persons to reduce the chances of causing pain and distress to an animal

  4. An animal must be monitored and assessed for signs of pain and distress frequently enough to ensure that any causative factors are promptly detected and managed.




  1. Institutions must regularly monitor and review institutional compliance of the code by ensuring that an independent external review is conducted at least every 4 years.

  1. True

  2. False



  1. Animal Ethics Executive must include the chairperson and at least one member from Category C or D

  1. True

  2. False

  1. When projects or activities that are in breach of the code arise, the AEC must ensure the following:

  1. Actions are taken to address the issues in consultation with the persons involved

  2. Actions are taken to ensure that animal wellbeing is not compromised, issue is addressed promptly and that activities that have the potential to adversely affect animal wellbeing are ceased.

  3. Non-compliance receives appropriate follow up

  4. All of the above

  1. When an animal dies unexpectedly, or is humanely culled due to unforeseen circumstances, which of the following must be undertaken?

  1. A necropsy should be performed by a competent person

  2. Prompt notification to the AEC is required

  3. Evaluation of current practices and procedures to be re-evaluated

  4. All of the above




  1. Which of the following statements best describes the Codes view in regards to an animals' capacity to feel pain?

  1. Animals do not feel pain

  2. All animal feel pain

  3. The extent to which animals experience pain is unknown, therefore in general it should be assumed that animals feel pain in the same manner as humans.

  4. Only certain species of animals experience pain.




  1. Which of the following statements best describes the purpose of the Code?

  1. To promote an understanding of the specific husbandry requirements of animals used for scientific purposes

  2. To encourage investigators to use animals for scientific purposes

  3. To promote the ethical, humane and responsible care and use of animals for scientific purposes

  4. To assist investigators in deciding what species of animal to use for scientific purposes




  1. Investigators have a personal responsibility for all matters that relate to the wellbeing of animals that they use, including housing, husbandry and care.

Which of the following statements is TRUE in regards to the length of time investigators must be responsible for the animals involved in their project?

  1. The investigator is responsible for animals that they use only until they no longer require them for their approved project or activity

  2. An investigators responsibility extends through the period of use approved by the AEC until provisions are made for the animal at the conclusion of their use.

  3. An investigator is not responsible for breeders and stock animals. Their responsibility is only in relation to animals to be used for ‘experimental purposes’, then ceases once these animals are no longer required.

  4. An investigator is only responsible for an animal when they are physically interacting with them.



  1. Which of the following is NOT detailed in the Code regarding the wellbeing of animals used for scientific purposes?

  1. Assessment of an animals' wellbeing can be undertaken by any employee of the Institute

  2. Animals must be cared for so as strain-specific or species-specific physiological and behavioural needs are met

  3. Living conditions within indoor facilities where animals are housed must be checked daily

  4. All animal must be identified either individually or in groups.




  1. Which of the following is an example of a technical refinement of an animal experimental?

(a) Cryopreserving sperm for a redundant mouse strain rather than continuing breeding

(b) Replacing an unreliable disease model with more efficient method of inducing disease

(c) Determining gene interactions using immortalized cell cultures instead of live animals

(d) Performing experiments upon rats instead of mice.



  1. When planning projects which of the following statements should be considered?

(a) Justification for use for animals

(b) Procedures using mice are performed competently

(c) Replacement, Reduction and Refinement are applied to all aspects of the project

(d) All are correct



  1. An AEC approved project or activity has been suspended. Which of the following statements is TRUE in describing when the project may re-commence?

  1. The project may re-commence once the investigator decides it is appropriate

  2. The project may re-commence only when it has been given approval to do so by the AEC

  3. The project may re-commence once an application to do so has been provided to the AEC

  4. The project may not re-commence at any stage.




  1. Which of the following welfare considerations regarding specific procedures is not described in Section 3: Animal wellbeing of the Code of Practice?

(a) Induction of tumours

(b) Modification of behaviour and neurological function Rehoming (Rehousing) to another investigator/project



  1. Xenotransplantation

  2. Routine Husbandry procedures




  1. Should animals undergoing non recovery surgical procedures remain unconscious throughout the procedure

  1. Yes

  2. No


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