Irrigation

The antibacterial effect of MTAD

• In vitro study, the antibacterial effects of MTAD, NaOCl, and EDTA were compared using a disk-diffusion test on agar plates.
• The results showed that even highly diluted MTAD produced clear zones of inhibition of the test bacterium, E. faecalis

• Torabinejad et al. 2003

The antibacterial effect of MTAD

• In vitro study, the effect of MTAD on root canals contaminated with either saliva or E. faecalis was evaluated, and reported good antibacterial activity.

• Shabahang et al. (2003)

• Shabahang & Torabinejad (2003)

Cytotoxicity of MTAD

• Cytotoxicity of MTAD was evaluated on fibroblasts.
• MTAD is less cytotoxic than eugenol, 3% H2O2, Ca(OH)2 paste, 5.25% NaOCl, Peridex (a CHX mouth rinse with additives), and EDTA, but more cytotoxic than 2.63%, 1.31%, and 0.66% NaOCl.

• Zhang et al. (2003)