Immune determinants of covid-19 disease presentation and severity

Viral recognition and innate immune responses

Viral entry. SARs-CoV-2 infects cells by attaching to the principal 

viral entry receptor, ACE2 (ref. 

has been reported in single-cell messenger-RNA-sequencing data 

on epithelial cells in the oral mucos

, liver, kidney, intestine and 

heart

the tissue distribution of protein expression differs to some exten

. 

Several reports have shown abundant expression of ACE2 in the 

intestinal epithelium leading to viral shedding via fe

ACE2 does not seem to be expressed by cells of the immune syst

.