(bioinformatics):
Sequence similarity
(bioinformatics):
Serialise (computing):
Server (computing):
Set (mathematics):
Setter (computing):
Side chains (molecular
biology):
Signal (computing):
Silent substitutions
(molecular biology):
A measure of the number or proportion of residues in two
aligned biological sequences that are exactly the same, i.e. have
the same kinds of residue at equivalent positions.
A measure of how alike two aligned protein sequences are,
accounting for the similarities and differences in the component
amino acids. Often the similarity is derived from a measure of
how substitutable different residues are in evolution.
Automatically convert in-memory data structures into a stream
of data that may be stored on disk, typically a plain text file. In
Python the inbuilt method of serialising data is called pickling.
The part of a computer application that does the work, e.g.
calculations, or putting together the contents of a webpage,
which is distinct, and often physically remote, from the client
with which the user interacts.
A collection of items which is unordered and where no item is
repeated.
A function that sets a specified attribute of an object to a
specified value. This can include verification that the value is
allowed.
When referring to the amino acid compounds that make up
proteins, the side chain is the part of an amino acid that varies
between the different types, and which sticks out from the
backbone (the part that is linked together to form chains).
With regard to graphical interfaces, particularly those based on
the Qt libraries, a signal is a notification sent out from a
graphical item to indicate that something has happened, e.g. the
item was clicked or resized. In Qt signals are connected to slots,
which are functions that are triggered in response to the signal.
A change within the protein-coding region of a gene’s DNA
sequence which does not result in a change in the protein
sequence. This occurs because an amino acid may be
represented by multiple different three-base codons in the
Similarity matrix
(bioinfromatics):
Simple linear regression
(mathematics):
Simulated annealing
(computing):
Single-nucleotide
polymorphism (SNP)
(molecular biology):
Singular value
decomposition (SVD)
(mathematics):
Slice (computing):
Slot (computing):
genetic code.
See substitution matrix.
In statistics, a linear fit of one distribution, Y, against a single
other distribution, X, with both usually provided by
measurements. Accordingly, we find a (y-axis intercept) and b
(gradient) such that Y = a + b X best fits the data, using a least-
squares calculation.
A global optimisation procedure, i.e. for finding the best overall
solution to a problem, that involves having a search strategy
which bases the next trial solution on the previous solution
using a parameter analogous to temperature. At a high
‘temperature’ subsequent solutions can be quite different from
one another (analogous to large thermal motion) and sample the
parameter space widely, but as the temperature is cooled the
differences become smaller, allowing the solution to refine and
approach a precise optimum. Simulated annealing can often find
good solutions to complex problems in a reasonable time.
A point of variation in a DNA sequence, often when comparing
individuals of the same species, consisting of a single base-pair
change.
A useful technique for decomposing a matrix into its
fundamental parts: a rotation, a scaling and another rotation.
Commonly used to find the optimal rotation which minimises
differences between spatial coordinates, i.e. to superpose/align
structures.
A means of accessing a range of elements in an ordered data
collection (like a Python list, text string or tuple) by specifying
the extent of the selection, rather than each item individually.
Referring to graphical user interfaces, especially for the Qt
libraries, a slot is a function belonging to one graphical object
that is invoked in response to a notification signal emitted from
another. This mechanism allows the coordination of graphical
items in response to a common set of data.
Sobel operator (images):
Spatial restraints
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