Python Programming for Biology: Bioinformatics and Beyond



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[Tim J. Stevens, Wayne Boucher] Python Programming

(bioinformatics):

Sequence similarity



(bioinformatics):

Serialise (computing):

Server (computing):

Set (mathematics):

Setter (computing):

Side chains (molecular



biology):

Signal (computing):

Silent substitutions

(molecular biology):

A measure of the number or proportion of residues in two

aligned biological sequences that are exactly the same, i.e. have

the same kinds of residue at equivalent positions.

A measure of how alike two aligned protein sequences are,

accounting for the similarities and differences in the component

amino acids. Often the similarity is derived from a measure of

how substitutable different residues are in evolution.

Automatically convert in-memory data structures into a stream

of data that may be stored on disk, typically a plain text file. In

Python the inbuilt method of serialising data is called pickling.

The part of a computer application that does the work, e.g.

calculations, or putting together the contents of a webpage,

which is distinct, and often physically remote, from the client

with which the user interacts.

A collection of items which is unordered and where no item is

repeated.

A function that sets a specified attribute of an object to a

specified value. This can include verification that the value is

allowed.


When referring to the amino acid compounds that make up

proteins, the side chain is the part of an amino acid that varies

between the different types, and which sticks out from the

backbone (the part that is linked together to form chains).

With regard to graphical interfaces, particularly those based on

the Qt libraries, a signal is a notification sent out from a

graphical item to indicate that something has happened, e.g. the

item was clicked or resized. In Qt signals are connected to slots,

which are functions that are triggered in response to the signal.

A change within the protein-coding region of a gene’s DNA

sequence which does not result in a change in the protein

sequence. This occurs because an amino acid may be

represented by multiple different three-base codons in the



Similarity matrix

(bioinfromatics):

Simple linear regression



(mathematics):

Simulated annealing



(computing):

Single-nucleotide

polymorphism (SNP)

(molecular biology):

Singular value

decomposition (SVD)

(mathematics):

Slice (computing):

Slot (computing):

genetic code.

See substitution matrix.

In statistics, a linear fit of one distribution, Y, against a single

other distribution, X, with both usually provided by

measurements. Accordingly, we find a (y-axis intercept) and b

(gradient) such that Y = a + b X best fits the data, using a least-

squares calculation.

A global optimisation procedure, i.e. for finding the best overall

solution to a problem, that involves having a search strategy

which bases the next trial solution on the previous solution

using a parameter analogous to temperature. At a high

‘temperature’ subsequent solutions can be quite different from

one another (analogous to large thermal motion) and sample the

parameter space widely, but as the temperature is cooled the

differences become smaller, allowing the solution to refine and

approach a precise optimum. Simulated annealing can often find

good solutions to complex problems in a reasonable time.

A point of variation in a DNA sequence, often when comparing

individuals of the same species, consisting of a single base-pair

change.

A useful technique for decomposing a matrix into its

fundamental parts: a rotation, a scaling and another rotation.

Commonly used to find the optimal rotation which minimises

differences between spatial coordinates, i.e. to superpose/align

structures.

A means of accessing a range of elements in an ordered data

collection (like a Python list, text string or tuple) by specifying

the extent of the selection, rather than each item individually.

Referring to graphical user interfaces, especially for the Qt

libraries, a slot is a function belonging to one graphical object

that is invoked in response to a notification signal emitted from

another. This mechanism allows the coordination of graphical

items in response to a common set of data.




Sobel operator (images):

Spatial restraints




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