Expand the main groups of rheumatic diseases in old age, their physiological and clinical features



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Case

Case 3

A 66-year-old man comes into your clinic as a new patient. Seven years ago at a

work-related health screening, he was diagnosed with hypertension and hypercholesterolemia.

At that time, he saw a physician who prescribed a diuretic and

encouraged him to lose some weight and to diet and exercise. Since that time,

the patient has not sought medical attention. During the past 2 months, he has

been experiencing occasional headaches, which he attributes to increased stress

at work. He denies chest pain, shortness of breath, dyspnea on exertion, or

paroxysmal nocturnal dyspnea. He smokes one pack of cigarettes per day and has

done so since he was 15 years old. He typically drinks two glasses of wine with dinner.

On examination, the patient is obese, and you calculate his body mass index

(BMI) as 30 kg/m2. His blood pressure is 168/98 mm Hg in the right arm and

170/94 mm Hg in the left arm. His blood pressure did not change with changes

in position. His heart rate is 84 bpm. He has no thyromegaly or lymphadenopathy.

Funduscopic examination reveals narrowing of the arteries, arteriovenous nicking,

and flame-shaped hemorrhages with cotton wool exudates. Cardiac examination

reveals that his point of maximal impulse is displaced 2 cm left of the midclavicular

line. There is an S4 gallop. No murmurs are auscultated. Lung and abdomen

examinations are normal.
What is your diagnosis?

What are your next steps?

Ticket 4


  1. Tell the effect of the change in the musculoskeletal system on the respiratory system.




  1. MCQ

1.A 65-year-old man with a history of rheumatoid arthritis is found to have a microcytic anemia. He had a colonoscopy 1 year ago which was normal and stool guaiac is negative. Which of the following is the most likely cause of his anemia?

A. Iron deficiency

B. Chronic disease

C. Pernicious anemia

D. Folate deficiency

2. A 68-year-old man is found to have an incidental finding of anemia while hospitalized with pneumonia. His physical examination is normal except for crackles in the left lower lobe. Serum laboratory examinations reveal a normal MMA and a decreased serum folate level. Which of the following is the best next step?

A. Administer CAGE questionnaire

B. Esophagogastroduodenoscopy

C. Serum iron assay

D. Neurology Consultation


3. A 70-year-old woman presents for evaluation of a lesion on her left cheek. It has been present for several months. It is slowly enlarging and bleeds if she scratches it. On examination, you find a 7 mm diameter pearly appearing papule with visible telangiectasias on the surface. Which of the following is the appropriate management of this lesion?

A. Close observation and reexamination in 3 months

B. Reassurance of the benign nature of the lesion

C. Excision

D. Local destruction by freezing with liquid nitrogen

4. A 78-year-old man with multiple medical problems presents with dysuria and is found to have microscopic hematuria. His examination is only positive for a very tender and boggy prostate. Which of the following is the best next step?

A. Stat urology referral.

B. Treat the prostatitis with 1 month of antibiotics and reevaluate the

patient with a follow-up urinalysis and culture posttreatment.

C. Obtain an IVP followed by cystoscopy.

D. Obtain a CT of the abdomen and pelvis, followed by cystoscopy.
3. Case
Case 4.

A 66-year-old man comes to the ER complaining of chest discomfort. He describes

the discomfort as a severe, retrosternal pressure sensation that had awakened him

from sleep 3 hours earlier. He previously had been well but has a medical history of

hypercholesterolemia and a 40-pack-year history of smoking. On examination, he

appears uncomfortable and diaphoretic, with a heart rate of 116 bpm, blood pressure

of 166/102 mm Hg, respiratory rate of 22 breaths per minute, and oxygen saturation

of 96% on room air. Jugular venous pressure appears normal. Auscultation

of the chest reveals clear lung fields, a regular rhythm with an S4 gallop, and no

murmurs or rubs. A chest radiograph shows clear lungs and a normal cardiac

silhouette. The electrocardiogram (ECG) is shown ST-segment elevation. Elevated CK-MB isoenzyme (Creatine Phosphokinase)
_ What is the most likely diagnosis?

_ What is the next step in therapy?


Ticket 5


  1. Select the features of the examination of the bronchopulmonary system in the elderly and senile age.

2.MCQ



        1. In Nephrotic syndrome, all serum proteins are reduced except -

  1. Transferrin b) Fibrinogen

  1. Albumin d) Ceruloplasmin



  1. Most common cause of nephrotic range proteinuria

in an adult is -

  1. Diabetes Mellitus

  2. Amyloidosis

  3. Hypertensive nephropathy

  4. Wegner's Granulomatosis



  1. Clinical feature of minimal glomerulonephritis are all except -

  1. Hypertension b) Edema

  1. Selective proteinuria d) Fever

4. A 67 -year-old man comes to the physician due to 2 days of back pain. He was moving boxes in his garage when the pain started. The pain is not relieved by lying down and increases in intensity when straining and coughing. He cannot sleep during the night due to pain, and has taken several acetaminophen tablets without relief. He has never had such pain before. He has point tenderness to palpation and percussion along the midline at the fourth lumbar vertebra. Which of the following is the most likely underlying etiology of this patient's current condition?

A. Apophyseal joint arthritis

B. Nerve root demyelinization

C. Ligamentous sprain [35%1

D. loss of bone mineral density

E. Nerve root demyelinization

3. Case


Case 5

A 42-year-old Hispanic woman presents to the ED complaining of 24 hours of

severe, steady epigastric abdominal pain, radiating to her back, with several

episodes of nausea and vomiting. She has experienced similar painful episodes

in the past, usually in the evening following heavy meals, but the episodes always

resolved spontaneously within an hour or two. This time the pain did not improve,

so she sought medical attention. She has no medical history and takes no medications.

She is married, has three children, and does not drink alcohol or smoke

cigarettes.

On examination, she is afebrile, tachycardic with a heart rate of 104 bpm, blood

pressure 115/74 mm Hg, and shallow respirations of 22 breaths per minute. She

is moving uncomfortably on the stretcher, her skin is warm and diaphoretic, and

she has scleral icterus. Her abdomen is soft, mildly distended with marked rightupper

quadrant and epigastric tenderness to palpation, hypoactive bowel sounds,

and no masses or organomegaly appreciated. Her stool is negative for occult

blood. Laboratory studies are significant for a total bilirubin (9.2 g/dL) with a direct

fraction of 4.8 g/dL, alkaline phosphatase 285 IU/L, aspartate aminotransferase

(AST) 78 IU/L, alanine aminotransferase (ALT) 92 IU/L, and elevated amylase level

1249 IU/L. Her leukocyte count is 16,500/mm3 with 82% polymorphonuclear cells

and 16% lymphocytes. A plain film of the abdomen shows a nonspecific gas pattern

and no pneumoperitoneum.

_ What is the most likely diagnosis?

_ What is the most likely underlying etiology?

_ What is your next diagnostic step?

Ticket 6


  1. List the common diseases of the bronchopulmonary system in the elderly and senile age.

2.MCQ
1. A 64-year-old man is noted to have congestive heart failure because of coronary artery disease. Over the past 2 days, he has developed progressive dyspnea and orthopnea. On examination, he is found to be in moderate respiratory distress, has JVD, and rales on pulmonary examination. He is diagnosed with pulmonary edema. Which of the following agents is most appropriate at this time?

A. Hydrochlorothiazide

B. Furosemide

C. Carvedilol

D. Spironolactone

E. Digitalis


  1. A 70-year-old African American man with New York Heart Association Class III heart failure sees you for follow-up. He has shortness of breath with minimal exertion. The patient is adherent to his medication regimen. His current medications include lisinopril 40 mg twice daily, carvedilol 25 mg twice daily, and furosemide 80 mg daily. His blood

pressure is 100/60 mm Hg, and his pulse rate is 70 bpm and regular. Physical examination findings include a few scattered bibasilar rales, an S3 gallop, and no peripheral edema. An ECG reveals a left bundle branch block and echocardiography reveals an ejection fraction of 25%. Which of the following is the best next step for this patient?

A. Increase the furosemide dosage to 80 mg twice daily.

B. Refer for coronary angiography.

C. Increase the lisinopril dosage to 80 mg twice daily.

D. Increase the carvedilol dosage to 50 mg twice daily.

E. Refer for cardiac resynchronization therapy.




  1. A 66-year-old woman has an average blood pressure of 150/70 mm Hg despite appropriate lifestyle modification efforts. Her only other medical problems are osteoporosis and mild depression. Her last lipid panel revealed a total cholesterol of 160 mg/dL, high-density lipoprotein (HDL) 40 mg/dL, and low-density lipoprotein (LDL) 90 mg/dL. Which of the following would be the most appropriate treatment at this time?

A. Lisinopril (Prinivil, Zestril)

B. Propranolol (Inderal)

C. Amlodipine (Norvasc)

D. Hydrochlorothiazide

E. Clonidine (Catapres)

4.A pt presents with longstanding gastric reflux, dysphagia and chest pain. On

barium enema, dilation of esophagus with tapering end is noted. He was found

with Barrett’s esophagus. He had progressive dysphagia to solids and then

liquids. What is the single most appropriate dx?

a. Esophageal carcinoma

b. Esophageal spasm

c. GERD


d. Barrett’s esophagus
3. Case
Case 6

A 64-year-old man presents with sudden onset of shaking chills, fever, and productive

cough. He was in his usual state of good health until 1 week ago, when he

developed mild nasal congestion and achiness. He otherwise felt well until last

night, when he became fatigued and feverish, and developed a cough associated

with right-sided pleuritic chest pain. His medical history is remarkable only for his

15-pack per year smoking habit. In your office, his vital signs are normal except for

a temperature of 102°F. His oxygen saturation on room air is 100%. He is comfortable,

except when he coughs. His physical examination is unremarkable except for

bronchial breath sounds and end-inspiratory crackles in the right lower lung field.

_ What is your diagnosis?

_ What is your next step?

Ticket 7


  1. Make a investigation plan for pneumonia in the elderly and senile age.

2.MCQ
1.A 60-year-old man with adenocarcinoma of the colon underwent left hemicolectomy with primary anastomosis. Thirty hours after surgery, he was found to have a fever of 102°F (38.8°C), blood pressure of 90/60 mm Hg, heart rate of 140 bpm, respirations of 24 breaths per minute, and low urine output. Physical examination showed diffusem abdominal tenderness. The surgical site is clean and Gram stain did not show any organism. Urinalysis (UA) was negative and the complete blood count (CBC) showed leukocytosis. Which of the following is the most likely cause of this patient’s fever?

A. Pneumonia

B. Intraperitoneal leak from bowel injury

C. Surgical site infection

D. Deep tissue abscess

2. A 78yo woman presents with unilateral headache and pain on chewing. ESR=

70mm/hr. She is on oral steroids. What is the appropriate additional tx?

a. Bisphosphonates

b. HRT hormonal replacement therapy

c. ACEi

d. IFN


e. IV steroids
3. The body of a 65yo man who was treated for TB and bronchitis

was seen at autopsy. His legs were swollen and his liver showed

signs of a transudate fluid. What was the cause of the transudate?

a. Liver cirrhosis.

b. Alcoholic liver disease.

c. Cardiac failure.

d. Budd-chiari syndrome.

e. TB.
4. A 55yo man has had severe pain in the right hypochondrium for 24h. The

pain comes in waves and is accompanied by nausea. Nothing seems to relieve

the pain. He feels hot and sweaty but has normal temp. What is the most

appropriate next inv:

A.US Abdomen

b. ERCP

c. MRCP


d. Serum amylase

e. UGI endoscopy


3.Case

Case 7


A 72-year-old man is admitted to the hospital because of acute onset of a right

facial droop, right arm weakness, and some difficulty speaking. These symptoms

started 6 hours ago while he was sitting at the breakfast table. He had no headache,

no diminishment of consciousness, and no abnormal involuntary movements.

Two weeks ago, he had a transient painless loss of vision in his left eye, which

resolved spontaneously within a few hours. His medical history is significant for

long-standing hypertension and a myocardial infarction (MI) 4 years previously,

which was treated with percutaneous angioplasty. His medications include a daily

aspirin, metoprolol, and simvastatin. He does not smoke. When you see him in

the emergency room, his symptoms have nearly resolved. He is afebrile, heart rate

62 bpm, and blood pressure 135/87 mm Hg. The corner of his mouth droops,

with slight flattening of the right nasolabial fold, but he is able to fully elevate his

eyebrows. His strength is 4/5 in his right arm and hand, and the rest of his neurologic

examination is normal. He has no carotid bruits, his heart rhythm is regular

with no murmur but with an S4 gallop. The remainder of his physical examination

is normal. Laboratory studies, including renal function, liver function, lipid profile,

and complete blood count (CBC), all are normal. Within a few hours, all of the

patient’s symptoms have resolved.

_ What is the most likely diagnosis?

_ What is the next step?

Ticket 8


  1. Assess the severity of the condition with pneumonia in the elderly and senile age.

2. MCQ


1. 65yo male with epigastric discomfort has been given triple therapy. He has

now returned after 4wks of epigastric discomfort. What inv would you do for

him?


  1. ECG

  2. H pylori breath test

  3. Endoscopy and biopsy

  4. US

2. An elderly male pt with prior hx of hematemesis is having hx of long term use

of aspirin and other drugs, now presents with severe epigastric pain, dysphagia

and vomiting. He was connected to vital monitors which were not reassuring.

What is the management?

a. Oral antacids

b. IV PPI

c. Oral PPI

d. Endoscopy

3. A 14yo boy has been dx with nephrotic syndrome. 5d later he presents

with flank pain, hematuria and fluctuating urea levels. A dx of renal vein

thrombosis is made. What is the most likely cause for renal vein thrombosis?

a. Protein C deficiency

b. Vasculitis

c. Loss of antithrombin III

d. High estrogen levels

4. A 67 yo man, known smoker, comes to the hospital with complaints of painless

hematuria, urgency and dysuria. He has been worried about his loss of weight

and reduced general activity. Which inv would be diagnostic of his condition?

a. Urine microscopy

b. Cystoscopy with biopsy

c. CT

d. Cystoscopy



e. US abdomen

3. Case


Case 8
A 68-year-old man comes to see you because of shortness of breath. He has experienced

mild dyspnea on exertion for a few years, but more recently he has noted

worsening shortness of breath with minimal exercise and the onset of dyspnea

at rest. He has difficulty reclining, and, as a result, he spends the night sitting up

in a chair trying to sleep. He reports a cough with production of yellowish-brown

sputum every morning throughout the year. He denies chest pain, fever, chills,

or lower extremity edema. He has smoked about two packs of cigarettes per day

since age 15 years. He does not drink alcohol. A few months ago, the patient

went to an urgent care clinic for evaluation of his symptoms, and he received a

prescription for some inhalers, the names of which he does not remember. He

was also told to find a primary care physician for further evaluation. On physical

examination, his blood pressure is 135/85 mm Hg, heart rate 96 bpm, respiratory

rate 28 breaths per minute, and temperature 97.6°F. He is sitting in a chair,

leaning forward, with his arms braced on his knees. He appears uncomfortable

with labored respirations and cyanotic lips. He is using accessory muscles of

respiration, and chest examination reveals wheezes and rhonchi bilaterally, but

no crackles are noted. The anteroposterior diameter of the chest wall appears

increased, and he has inward movement of the lower rib cage with inspiration.

Cardiovascular examination reveals distant heart sounds but with a regular rate

and rhythm, and his jugular venous pressure is normal. His extremities show no

cyanosis, edema, or clubbing.

_ What is the most likely diagnosis?

_ What is the next best diagnostic test?

_ What is the best initial treatment?

Ticket 9


  1. List the features of age-related alteration in digestion.(5 points)

2. MCQ
1.A 76-year-old widowed man who lives alone presents to clinic with increasing shortness of breath and chest pain at rest forthe past 2 weeks. He has had chronic hypertension and coronary artery disease (CAD) for 20 years for which he takes hydrochlorothiazide (HCTZ), enalapril, and aspirin 81 mg daily. Other medical problems include hyperlipidemia, peripheral vascular disease, and gastroesophageal reflux disease (GERO) which are controlled by lovastatin, warͽrin, and omeprazole. Two years ago, he suȸered a cerebrovascular accident that was localized to the brain stem. He now has dysphagia and is noted to cough Ũequently at night. He has no cough at present and has not been able to take his temperature at home. Which of the following is the best next step?

A. Upper endoscopy

B. Removal of angiotensin-converting enzyme (ACE) inhibitor

C. Nitroglycerine patch

D. Chest radiograph

2. A 64yo alcoholic who has been dx with liver cirrhosis presents with a massive

ascites. What is the mechanism of fluid accumulation in a pt with liver disease?

a. Cirrhosis

b. Portal HTN

c. Hypoalbuminemia

d. Liver failure

e. Hepatic encephalopathy

3. A 66 yo man has an intermittent epigastric pain for 3wks. It is worse by

food but helped by some tablets he obtained from the pharmacy. He had a

similar episode 3yrs ago and his doctor gave him a course of 3 types of tablets

at the time. What is the most appropriate next inv?

a. Abdomen US

b. Barium meal

c. Serum H.Pylori antibodies

d. Urea breath test

e. Upper GI endoscopy

4. A 65yo man complains of hematuria, frequency, hesistancy and

nocturia. He reports that on certain occasions he finds it difficult to control the

urge to pass u9rine. Urine microscopy confirms the presence of blood but no

other features. What is the most porbable dx?

a. BPH

b. Bladder ca



c. Prostatic cancer

d. Pyelonephritis

e. Prostatitis

3. Case


Case 9

A 61-year-old woman presents to the ER complaining of a 4-week history of progressive

abdominal swelling and discomfort. She has no other gastrointestinal

symptoms, and she has a normal appetite and normal bowel habits. Her medical

history is significant only for three pregnancies, one of which was complicated by

excessive blood loss, requiring a blood transfusion. She has been married and

monogamous for 20 years, exercises, does not smoke, and drinks only occasionally.

On pointed questioning, however, she does admit that she was “wild” in her

youth, and she had snorted cocaine once or twice at parties many years ago. She

does not use drugs now. She was HIV negative at the time of the birth of her last

child.

On examination, her temperature is 100.3°F, heart rate 88 bpm, and blood pressure



94/60 mm Hg. She is thin, her complexion is sallow, her sclerae are icteric,

her chest is clear, and her heart rhythm is regular with no murmur. Her abdomen

is distended, with mild diffuse tenderness, hypoactive bowel sounds, shifting dullness

to percussion, and a fluid wave. She has no peripheral edema. Laboratory

studies are normal except for Na 129 mEq/L (normal 135-145), albumin 2.8 g/dL

(normal 3.5-5 g/dL), total bilirubin 4 mg/dL, prothrombin time 15 seconds (normal

11-13.5 s), hemoglobin 12 g/dL with mean cell volume (MCV) 102 fL (normal 78-95),

and platelet count 78,000/mm3 (normal 150 000-500 000).

_ What is the most likely diagnosis?

_ What is your next step?

Ticket 10

1.Expand the main groups of rheumatic diseases in old age, their physiological and clinical features

2.MCQ

1. A 65yo man presented with frank hematuria. He has no other urinary



symptoms. What is the most appropriate next step that will lead to the dx?

a. Transrectal US


b. US Abdomen

c. Cystoscopy

d. Mid-stream urine for culture
2. An 80yo man presented with pain in his lower back and hip. He also complains

of waking up in

the night to go to the washroom and has urgency as well as dribbling. What is

the most likely dx?

a. Bladder carcinoma

b. Prostatitis

c. UTI

d. Prostate carcinoma


3.A young boy presented with bilateral periorbital edema, ankle swelling and

increase in body weight. What is the most likely dx?

a. Chronic heart failure

b. Nephrotic syndrome

c. Renal failure

d. Acute heart failure

e. Glomerulonephritis
4. A 60yo man complains of tiredness, lethargy and itching that is severe after a

hot bath. He also has nocturia, polyuria and nausea and vomiting. Exam: pallor,

pigmentation and generalized

edema. What is the single most likely dx?

a. Hyperthyroidism

b. Chronic renal failure.

c. Liver failure

d. Eczema


3. Case


Case 10

A 65-year-old man comes to an outpatient clinic complaining of low-grade fever

and sore throat, and he receives an injection of intramuscular penicillin for presumed

streptococcal pharyngitis.

Within 20 minutes, he begins to complain of swelling of his face and

difficulty breathing. He looks dyspneic and frightened. His heart rate is 130 bpm,

blood pressure 90/47 mm Hg, and respiratory rate 28 breaths per minute and

shallow. His face and lips are edematous, and he can barely open his eyes because

of swelling. He is wheezing diffusely, and he has multiple raised urticarial lesions

on his skin. An ambulance has been called.

_ What is the most likely diagnosis?

_ What is your next step?


Ticket 11

  1. Tell the main research methods in cardiology practice in elderly patients and their indication and contraindication

2. MCQ

1. A 66 year old woman presents with generalized

edema, skin ulceration and hypertension. Urine examination shows subnephrotic proteinuria (< 2gm) and microscopic haematuria. Serum complement levels are decreased and she is positive for anti­hepatitisс antibodies. The likely diagnosis is -



  1. PSGN

  2. Essential mixed cryoglobulinemia

  3. Membrano proliferative glomerulonephritis

  4. Focal segmental glomerulosclerosis

2.Urinalysis shows RBC casts; likely source is -

a) Kidney b) Ureter

Bladder d) Urethra


3. A 65yo man with colon cancer now develops increased thirst, increased

frequency in urination and weight loss. His fasting blood glucose=9mmol/L.

what is the most appropriate management?

a. Oral hypoglycemic

b. Insulin long acting

c. Short acting insulin before meal

d. IV insulin

e. Subcutaneous insulin


4. A 61yo man who had stroke 2y ago is on aspirin. He has RA but suffers from

pain and can’t tolerate it. He is taking senna for constipation. What is the best

med to relieve his pain?

a. DMARDs

b. Ibuprofen

c. Co-codamol- cause constipation

d. Paracetamol- osteoarthritis



  1. Case

Case 11


A 61-year-old man presents to your office with the complaint of cough. The cough

began approximately 3 months prior to this appointment, and it has become more

annoying to the patient. The cough is nonproductive and worse at night and after

exercise. He has had a sedentary lifestyle but recently started an exercise program,

including jogging, and says he is having a much harder time with the exertion. He

just runs out of breath earlier than he used to previously, and he coughs a great

deal. He has not had any fever, blood-tinged sputum, or weight loss. He denies

nasal congestion and headaches. He does not smoke and has no significant medical

history. His examination is notable for a blood pressure of 134/78 mm Hg and

lungs that are clear to auscultation bilaterally, except for an occasional expiratory

wheeze on forced expiration. A chest radiograph is read as normal.

_ What is the most likely diagnosis?

_ How would you confirm the diagnosis?

Ticket 12

1.Describe the clinic in elderly people and complications of AMI
2.MCQ

1. Central nervous system manifestion in chronic renal failure are a result of all of the following except -

a) Hyperosmolarityb) Hypocalcemiac) Acidosis d) Hyponatremia
2.All the following indicates CRF, except


  1. Anaemia

  2. Small kidneys

  3. Heperproteinemia

  4. Constrictive pericarditis

e)Peripheralneuropathy
3.Progressive dysphagia is seen in-

a) Carcinoma esophagus b) Globus hystericus

  1. Presbyesophagus d) Achalasia

4.All are used in treatment of Helicobacter pylori, EXCEPT-



  1. Colloid bismuth b) Cisapride

  1. Clarithromycin d) Metronidazole


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