33
System biolog
y
Steering of the process of penetration of chemical substances into biosystem structure
Fig. 3.
Dynamic behavior of the interface between implant
(left) and bauds tissue (right) [8]
Investigative approach should, however, take into account
the compiled structure of skin tissue (Fig. 1). The skin consists
from three main layers. Epidermis is the most external protec
-
tive skin layer, the next one is dermis as a median vascularized
layer and the third an internal hypodermis consisting from a fatty
tissue layer and connective tissue. The skin contains also hair
follicle and bulbs as well as sebaceous and sweat glands. The
skin is covered by a horny layer called stratum corneum. Such
stratiied structure implies the different ways of penetration of
xenobiotics, from a straight line of diffusion by skin to proper
skin, to different way of transportation through glands channels
or hair follicle (Fig. 2). External stratum corneum is built from
several dry layers of keratynocites and due to this is a natural,
most dificult, obstacle for penetration of ksenobiotics. Also the
mechanism of their transportation is dificult to predict. It is as
-
sumed that in this layer the process of penetration of chemicals
into organism depends on passive penetration by a sequence
of layers of cells. Next, numerous metabolic conversions as well
as xenobiotic biotransformation take place in the internal layer
of epidermis. Any activating of this layer will cause a different
course of penetration of different xenobiotics and it is a chal-
lenge for an the cosmetic, pharmaceutical and military industry
investigators. The hydration of the stratum corneum as well as
the change of pH of skin by different solutions or removal lipids
from a skin causes a change in its structure, which results in
a considerable growth of penetrability of skin for an individual
xenobiotics. A different use of various and passive xenobiotics
will cause an increase of the resistance of the skin against differ-
ent toxic substances. The skin penetration process depends on
time, but penetration by a stratum corneum is the limiting factor
for the speed of the whole process. As the result, the duration
of the exposure to xenobiotics is the most essential factor in
this case. Moreover, it means also that the quick termination of
the contact with xenobiotics, by washing or wiping it off, is the
most important action.
In order to achieve progress in close local treatment methods,
one should again analyze the investigative procedures. The The
author, considering problems of pharmacokinetics in global treat-
ment, proposed the methodology of analysis of local treatment
including active treating substances in implants, showing that the
program of steering is the beginning of an important medical chal-
lenge for chemical laboratories and pharmaceutical industry [9].
Local treatment is also a challenge for material engineer-
ing, in the range of construction of new composites with active
structures including a new generation of medicines characterized
by a selective memory for treatment of a speciic organ related
with its disfunction and a deinition of the individual of sickness
(Fig. 3). For instant, the demand that the medical impulse should
come from the implant containing a speciic medicine has a soliton
characterization which is particularly valuable for patient treat-
ment, forces a further analysis of the question.
The new composites are also a challenge for material engi-
neering in range of construction in regard of active structures,
including with selective memory the new generation of medicine
implants of treatment of concrete organ, related with its disfunc-
tion and the given individual sickness.
The essence of the proposition for solution of this problem
is the test for a better control of process penetration and the
possibility of steering of that process, realized on the base of
statistical estimation of the transportation process, formulated in
a suitable variation method basing on variation calculation which
is well-known in literature [10], [11], [12].
Main result
The diffusive descriptions differ fundamentally from descriptions
with approach got by the help of variation calculations. Skipping
the only fact of paradoxical unrestricted speeds of a diffusive
impulse as well as non dynamic irreversibility, we receive the
thickness ield of a medium or temperature in result. However, the
essence of a variation approach is the question of inding of the
best trajectories of the guided impulse, for example the treating
one, and of course, the steering of such optimum impulse. This
kind of solution is the most coherent with the medical methodology
of the treatment of an area, which makes up the focus of disease.
Let us recall the essence of an arithmetic base approach
to the problem of getting such optimum useful structures also
in medicine. The formula of getting the optimum structures is
the problem of inding the best geometries for functional called
Hamiltonian of type
∫
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