Dificulties in developing algorithms for application of physical methods…
or fever therapies. The antidepressant and antipsychotic drugs
that are used today were developed as late as the middle of the
20
th
century. Before that time, various herbal medicines including
opiates, alcohol and hypericum extracts were used in treatment
of mental disorders [4].
Since the Antiquity numerous physical methods using mag-
netic or electric phenomena have been used. Therapies tried to
make use of the natural sources of these phenomena, like amber,
magnetite or electric ish. In a later period, due to the progress
of technology, medicine started to use Voltaic piles, electrostatic
generators and various electric stimulators as well as artiicial
magnets and magnetic ield generators [5, 6].
The best known method of physical treatment in psychiatry is
electroconvulsive therapy (ECT) introduced into clinical practice
in 1938 by Cerletti and Bini. They were the result of numerous
and long-lasting attempts at using electric stimulation in therapy
of mental disorders based on observations connected with
chemically induced (indoklon, cardiazol) convulsions. Cerletti
and Bini managed to select the current parameters that were
able to trigger seizure activity of the brain [7]. It is interesting
that the irst application of ECT was preceded by several years
of experiments of animals, which was then (in the 1940s) hardly
ever practiced, and which is now an obligatory requirement
of admission of new pharmacologically active substances for
clinical studies [8].
Electroconvulsive therapy proved to be highly effective at
controlling of both psychotic symptoms and affective disorders
(in depression as well as in mania), making it possible for chronic
patients to function fairly well in everyday life [9]. As compared
to the chemical methods of inducing convulsions, ECY turned
out to be safer and easier to administer. It was easier to control
the dose of the stimulus (here: electric current) necessary to
trigger a seizure. Moreover, convulsions were manifested im
-
mediately and not after a longer or shorter delay (in the case
of chemically induced convulsions), during which the patient
experienced discomfort.
Electroconvulsive technique was readily adopted in numerous
psychiatric centers and soon became quite popular – initially
applied larga manus in most psychiatric disorders.
The irst two decades since the introduction of ECT into
clinical practice were the period of intensive clinical studies,
application of electroconvulsive procedures in various psychi-
atric disorders and accumulation of experience which allowed
physicians to develop optimum (effective and safe) schemes of
treatment, e.g. [8]:
–
indications and counter-indications for application of ECT
were developed (renouncing application of ECT in disor-
ders in which it proved little effective),
–
the regime of 4-15 procedures in a series was introduced,
replacing mega-schemes (several dozen to several hun-
dred procedures in a series, which could be highly danger-
ous and threatening with numerous side-effects),
–
sine waves of the current were replaced by square waves
(less burdening energetically),
–
unilateral procedures were proposed in the place of bilater-
al ones (which, on the one hand, is safer as regards the risk
of the occurrence of memory disorders and disturbances of
other cognitive functions, but, on the other hand, is clinically
less effective),
–
application of pharmacologically modiied procedures
(short-term general anesthesia + muscle relaxation + oxy-
genation) decreased the risk of complication in the osseous
system and cardiovascular system,
–
monitoring of the seizure activity was introduced (seizures
lasting at least 30 seconds were recognized as clinically
effective, shorter ones were described as abortive – having
no clinical effectiveness),
–
appropriate legal mechanisms for application of ECT were
developed (the procedure of obtaining the patient’s in-
formed consent was introduced).
The 1960s witnessed a certain „downfall” of ECT [10]. Three
main reasons for this state of things can be discerned:
–
Indications for application of ECT were seriously limited as
a result of hitherto observations and studies indicating little
effectiveness of ECT or its absence in nervous disorders,
situational disturbances, personality disorders, etc.
–
Modern antidepressant and antipsychotic drugs were in-
troduced and popularized in clinical practice, assuming the
role of irst-stage treatment in most psychiatric disorders.
–
Patient’s rights movement developed, demanding drastic
limitation of application of ECT and even completely reject-
ing psychiatry as a medical science (here the most impor-
tant trend was the so-called anti-psychiatry).
In turn, in the recent decades we have had to do with
a speciic revival of ECT. Pharmacotherapy has not fulilled the
hopes pinned upon it. Its effectiveness amounting to 60-65%
is recognized as lower than that of ECT (70-90%). There are
still many patients for whom pharmacological therapy proves to
be insuficiently effective and the intensity of ailments requires
more invasive treatment including electroconvulsive therapy.
Introduction of the mechanisms listed above allowed for signiicant
improvement of safety of the therapy as well as the patient’s
comfort. Thus, so far, anti-psychiatry and its epigones have not
managed to marginalize psychiatry or get rid of biological methods
of psychiatric treatment (anti-psychiatry rejected not only ECT
but also pharmacological therapy).
Present status quo
Electroconvulsive therapy is practically one of the old physical
methods of psychiatric treatment, which managed to survive up
today - mostly due to its high effectiveness and signiicant safety.
More frequent use of ECT procedures is seriously limited by
their unfavorable associations and the necessity of application
in hospital conditions with the use of anesthetic techniques (gen-
eral anesthesia and muscle relaxation) as well as the traditions
of application of ECT in a given center and availability of ECT
equipment. Moreover, as it has already been mentioned, mental
disorders of lesser intensity or of situational etiology respond fairly
well to pharmacological treatment in outpatient clinics. Hence,
prescribing of ECT in this kind of cases would be unjustiied.
Also, numerous more severe cases of mental disorders
respond fairly well to intensive pharmacotherapy applied in hos-
pitals, so there is no need to apply ECT procedures.
Due to its high safety, good availability, easy administration
and low cost, pharmacological treatment is commonly recognized
as the irst-choice therapy. Patients suffering from mental disor
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