Editorial board editor-in-chief

Keywords:
progress of medicine, steering of the processes, analysis of medicine penetration 

---

32
System biolog
y
Steering of the process of penetration of chemical substances into biosystem structure
Introduction 
The skin tissue is an effectively operating barrier, separating 
organism from surroundings, which has been formed by millennia 
of evolutionary development, and it is the organ of senses which 
contact us with the environment. It prevents the uncontrolled 
low of different media from and to organism, from one side, 
on the other hand, however, the contact with environment is 
absolutely indispensable for the functioning of the organism. As 
the largest external organ of human substance, with the surface 
of about 2m
2
and the thickness from 0,1 to 5mm average, it 
protects before the microbes invasion, it assures gas exchange, 
by skin we loss the excess of warmth created by exercise, it is 
a receptor of temperature as well as moisture of surroundings, 
responsible for energetistic equilibrium of organism. Due to the 
kind of potential functions it fulils, the skin is also perceived as 
a semi-conductive barrier or as the diaphragm, through which 
it can diffuse xenobiotics harmful for health from the environ-
ment into interior of organism. However, it can also be helpful 
on passing many healing substances, which easily diffuse into 
biosystem by porous tissue. Therefore, this natural diaphragm 
has been under the interest of many industrial, pharmaceutical 
and cosmetic companies, textile industry, economic chemistry 
as well as military industry thorough the world [1]. 
This problem is particularly important in the selection of suit-
able active substances which will accelerate or delay, in a well-
known manner, the process of penetration of suitable medicine 
through organic diaphragm into structure which undergoes of 
medical treatment for achievement of the expected aim. The 
penetration through skin tissue of substance of type as the caf-
feine, theophylline stimulating the central nervous system can be 
an example of use for deceleration of process of fatigue or the 
enlargement of durability and the physical resistance as well as 
the upward movement of vigilance or the man’s cognitive abilities 
[2]. Penetration in osseous tissue of medicine from implant is 
another example where it is delivered according to constructed 
script of medicine interaction [3]. Acquaintance of the kinetics 
of process penetration in both different medical situations will 
permit to qualify parameters for steering of this phenomenon. 
It creates then the possibilities for study of new constructions, 
as for instance new generation of sensors applied in surgical 
navigation in compiled operations of removing the cancer cells 
of head or the neck for assurance of the local treatment. 
The review of literature shows that processes of penetra-
tion have been described mainly by the aim of the diffusive 
mechanism, but a closer analysis of the question discloses that 
is somehow a simpliication of the problem [4], [5], [6].
The authors usually accept one simplest pattern, where 
they study the penetration through natural diaphragm as well 
as the artiicial placed in Franz diffusive cell. Supposing the 
steady state of penetrating process, they record the quantity 
of xenobiotics passing in time and receive the stream of pen-
etration of given substances from inclinations of straight line
in 
m
g/cm2/h or accumulated concentration after 24h concentra-
tion, Q24 (
m
g/cm2). The linear range of resultant data is looking 
for cases where steady streams occur, but there is a need for 
an estimation of calculation in other cases which brings large 
uncertainties of measurements. The reason is that in fact the 
structure of diaphragm is not uniform. 
In reaction of penetrating mass of an implant into osseous 
tissue, the variation formulation has given the solution as a dif-
ferential equation describing the speed of penetration of mass 
of an implant.